Cerebrovascular Fellowship Training Program

脑血管奖学金培训计划

• 批准号: 10665618
• 负责人: Daniel Woo
• 金额: $ 39.21万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665618
• 关键词: Fellowship; Training Programs; cerebrovascular

This highly focused, competitive renewal application for a Research Training Grant (T-32) is designed to develop physicians as independent clinical scientists in the area of cerebrovascular disease and neurocritical care. Our current training program includes extensive hands-on experience in clinical research and trials within a broad array of NIH-funded, T-2-focused, translational research. Our program includes close mentoring with selection of specific research projects within the first year of the program, well-defined course work, and unique training in the evaluation and treatment of patients with acute stroke and neurocritical care. Our post-doctoral training program has been training neurologists for 22 years and emergency physicians formally for 16 years with the goal of producing academic leaders and clinical researchers in the area of cerebrovascular disease and neurocritical care. The last 15 years of our program have included funding by this T32. Since the initiation of the T32, we have developed a very robust neurocritical care training pathway which we have included as part of this T32 training program. This innovative and multi-disciplinary training model has been advocated by the NIH roadmap and by the NIH-funded Centers for Clinical and Translational Science and Training (CCTST). Our training program is comprised of an extensive network of collaborators and mentors that has resulted in academic productivity among our graduates. Training draws on faculty with expertise in acute stroke therapy and clinical trial methodology/management, genomics, hemorrhagic stroke, animal models and in-vitro models of stroke and vascular physiology, traumatic brain injury, methods of neurocritical care, neuroepidemiology, biostatistics, neuro-interventional therapy (endovascular and surgical), neuroimaging, neurorecovery, neurosonology, neurotechnology development, outcome research, stroke prevention, ethical design of research, HIPAA compliance, and data-base management. New this submission is an additional level of focus on the type of clinical/translational stroke research pursued; we now have pathways for those that intend to pursue designing and implementing clinical trials, and a separate track for those interested in more of the epidemiology/outcomes/genetics path. Individuals trained in our program prior to and during the T32 period have been productive thus far as measured by academic appointments, publications, and subsequent grant awards. This relatively rare T32 program designed for post-doctoral physician scientists performing clinical research is significant and desperately needed value added to the standard stroke clinical training programs that exist today. Potential trainees must have completed a residency in neurology or emergency medicine and must demonstrate a commitment to an academic career in cerebrovascular disease and/or neurocritical care; minority recruitment is emphasized. We are requesting continuing support for up to four post-doctoral positions per year (maximum of two fellows per year for two years of training support).

这项高度集中，竞争性的更新疗法在研究培训补助金（T-32）中旨在发展医生，成为脑血管疾病和神经严重护理领域的独立临床科学家。我们当前的培训计划包括广泛的NIH资助，以T-2为重点的转化研究的临床研究和试验的丰富动手经验。我们的计划包括在该计划的第一年内仔细指导特定研究项目，定义明确的课程工作，以及在评估和治疗急性中风和神经关怀患者方面的独特培训。我们的博士后培训计划已经培训神经科医生已有22年，正式的急诊医生已有16年的历史，目的是在脑血管疾病和神经临床护理领域培养学术领导者和临床研究人员。我们计划的最后15年包括该T32的资金。自从T32启动以来，我们开发了一种非常强大的神经严格的护理培训途径，作为该T32培训计划的一部分，我们已将其包括在内。 NIH路线图和NIH资助的临床和转化科学与培训中心（CCTST）提倡这种创新的多学科培训模型（CCTST）。我们的培训计划由广泛的合作者和导师网络组成，这些网络已导致毕业生的学术生产力。培训利用急性中风疗法和临床试验方法/管理，基因组学，出血性中风，动物模型，动物模型和卒中和血管生理学的体外模型的培训，创伤性脑损伤，神经行权护理的方法，神经性部位学，神经体系学，生物体系学，神经内在的疾病和疾病（ENURO Inter）（脑膜化和脑膜外）神经记录，神经病学，神经技术的发展，结果研究，预防，研究道德设计，HIPAA合规性和数据库管理。新的提交是对所追求的临床/转化中风研究类型的另一种关注。现在，对于那些打算追求设计和实施临床试验的人的途径，对于那些对更多流行病学/结果/遗传学路径感兴趣的人来说，这是一个单独的轨道。迄今为止，通过学术任命，出版物和随后的授予奖项来衡量，在T32期间和期间接受了我们计划培训的个人。这项针对博士后医师科学家设计的相对罕见的T32计划是进行临床研究的重要且迫切需要的，这是今天存在的标准中风临床培训计划。潜在的学员必须完成神经病学或急诊医学的居住权，并且必须表现出对脑血管疾病和/或神经关怀的学术职业的承诺；强调少数民族招募。我们要求每年最多四个博士后职位（两年的培训支持每年最多两个研究员）继续支持。

项目成果

Analysis of tissue plasminogen activator eligibility by sex in the Greater Cincinnati/Northern Kentucky Stroke Study.

• DOI: 10.1161/strokeaha.114.006737
• 发表时间: 2015-03
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Madsen TE;Khoury JC;Alwell KA;Moomaw CJ;Kissela BM;De Los Rios La Rosa F;Woo D;Adeoye O;Flaherty ML;Khatri P;Ferioli S;Kleindorfer D
• 通讯作者: Kleindorfer D

The Effect of Antidepressants on Depression After Traumatic Brain Injury: A Meta-analysis.

• DOI: 10.1097/htr.0000000000000439
• 发表时间: 2019
• 期刊: The Journal of head trauma rehabilitation
• 作者: Kreitzer N;Ancona R;McCullumsmith C;Kurowski BG;Foreman B;Ngwenya LB;Adeoye O
• 通讯作者: Adeoye O

The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial.

• DOI: 10.1161/strokeaha.108.517656
• 发表时间: 2008-12
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Pancioli AM;Broderick J;Brott T;Tomsick T;Khoury J;Bean J;del Zoppo G;Kleindorfer D;Woo D;Khatri P;Castaldo J;Frey J;Gebel J Jr;Kasner S;Kidwell C;Kwiatkowski T;Libman R;Mackenzie R;Scott P;Starkman S;Thurman RJ;CLEAR Trial Investigators
• 通讯作者: CLEAR Trial Investigators

Patients living in impoverished areas have more severe ischemic strokes.

• DOI: 10.1161/strokeaha.111.649608
• 发表时间: 2012-08
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Kleindorfer D;Lindsell C;Alwell KA;Moomaw CJ;Woo D;Flaherty ML;Khatri P;Adeoye O;Ferioli S;Kissela BM
• 通讯作者: Kissela BM

The Experience of Caregivers Following a Moderate to Severe Traumatic Brain Injury Requiring ICU Admission.

• DOI: 10.1097/htr.0000000000000525
• 发表时间: 2020
• 期刊: JOURNAL OF HEAD TRAUMA REHABILITATION
• 影响因子: 2.4
• 作者: Kreitzer, Natalie;Bakas, Tamilyn;Kurowski, Brad;Lindsell, Christopher J.;Ferioli, Simona;Foreman, Brandon;Ngwenya, Laura B.;Thomas, Stephanie;Keegan, Sara;Adeoye, Opeolu
• 通讯作者: Adeoye, Opeolu