Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)

脑出血的民族/种族变异 (ERICH)

基本信息

批准号：
8539089
负责人：
Daniel Woo
金额：
$ 565.9万
依托单位：
UNIVERSITY OF CINCINNATI
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8539089
关键词：
5 year old Accounting Acquired Immunodeficiency Syndrome Admission activity Admixture Adult Affect African American Age Alleles Alzheimer&apos s Disease American Apolipoprotein E Blood Vessels Brain Brain hemorrhage Brain imaging Candidate Disease Gene Case-Control Studies Cause of Death Censuses Cerebral hemisphere hemorrhage Cessation of life Characteristics Classification Clinical Collection DNA Data Data Collection Digit structure Disabled Persons Epidemiology Ethnic Origin Ethnic group Film Future Gender General Hospitals Genes Genetic Genetic Polymorphism Genome Scan Genomics Genotype Geographic Locations Goals Health Care Costs Healthcare Heart Diseases Hemorrhage Hispanic Americans Hispanics Hospitals Human Image Individual Injury Institutes Interview Ischemic Stroke Lead Leukoaraiosis Life Literature Lobar Location Magnetic Resonance Imaging Malignant Neoplasms Massachusetts Measures Mediating Methodology Methods Mexican Minority Minority Groups Morbidity - disease rate National origin Neurologic Not Hispanic or Latino Outcome Patients Persons Phenotype Population Prevention Process Proteomics Puerto Rican Quality Control Race Reading Recruitment Activity Relative (related person)Research Research Personnel Risk Risk Factors Rupture Sample Size Sampling Scanning Severities Socioeconomic Factors Stroke Survivors Testing United States Universities Variant White Matter Disease apolipoprotein E-2 apolipoprotein E-4 base biobank care burden case control clinical practice comparison group design disability effective therapy experience forest genetic risk factor genome wide association study high risk improved interest mortality neuroimaging public health relevance racial and ethnic racial difference regional difference repository sample collection statistical center

项目摘要

DESCRIPTION (provided by applicant): Intracerebral hemorrhage (ICH) occurs when a blood vessel ruptures within the brain parenchyma leading to neurologic injury and frequently death. Approximately 40-50% of patients who suffer from an ICH will die from the hemorrhage. Of the survivors, the majority are disabled. Thus, ICH is the subtype of stroke with the highest morbidity and mortality rates. Minority populations of African-Americans and Hispanics have been found to have roughly double the rate of ICH as whites and on average, have ICH at a younger age. Yet despite this disproportionate health care burden, fewer than 200 ICH cases among African-Americans and less than a hundred ICH cases among Hispanics have been collected with DNA available for testing. Our proposal is to collect 1000 cases of ICH among whites, 1000 cases of ICH among blacks, 1000 cases of ICH among Hispanics, and 3000 controls matched to the cases by race/ethnicity, age (5 years), gender and geographic location. Our long-term goal is to perform a genome-wide association study of intracerebral hemorrhage which includes a significant proportion of minorities with ICH. A genome-wide association study evaluates DNA with hundreds of thousands of markers to identify regions or genes which are associated with either a greater or lesser risk of ICH. However, the current proposal will not complete this type of analysis as insufficient numbers are currently available. Thus, the goals of the current proposal are to: 1) understand the risk factors of greatest importance for ICH among blacks and Hispanics; 2) determine differences in brain-imaging by race/ethnicity; 3) determine factors that mediate differences in outcomes rates by race/ethnicity; and 4) determine if Hispanics and African-Americans from different regions or national origin (such as Mexican, Cuban, etc.) are genetically different. To accomplish these goals, we have 11 recruitment centers representing 30 recruitment hospitals throughout the United States with large populations of African-Americans and Hispanics. White ICH cases from the same regions will also be recruited to account for regional differences in risk factors as well as a comparison group for risk factors, outcomes and imaging differences. A centralized neuroimaging center will be developed for uniform reading and analysis of films at Massachusetts General Hospital in conjunction with Georgetown University. A biorepository will be developed for centralized DNA processing and sample handling at the Miami Institute for Human Genomics. And a data and statistical center will be developed at Wake Forest University. The major advantages of this study are the experience of the investigators, particularly with recruitment of minority populations and particular interest in ICH and epidemiology; uniform definitions of cases, risk factors, and centralized analyses; and the ability to identify and recruit the large number of subjects (6000 total) required for the study.

描述（由申请人提供）：脑内出血（ICH）发生时，当血管在脑实质内破裂导致神经系统损伤并经常死亡时。大约40-50％的ICH患者会因出血而死亡。在幸存者中，大多数是残疾人的。因此，ICH是中风的亚型，发病率和死亡率最高。已经发现，非裔美国人和西班牙裔人的少数族裔人口大约是白人的ICH率的两倍，并且平均而言，ICH年龄较小。然而，尽管有不成比例的医疗保健负担，但在非裔美国人中，少于200个ICH案件和西班牙裔中的一百个ICH案件不到一百个ICH案件，可用于测试DNA。我们的建议是在白人中收集1000箱ICH，黑人中的1000例ICH案例，西班牙裔中的1000例ICH案例，以及与种族/民族，年龄（5岁），性别和地理位置相匹配的3000例控制。我们的长期目标是对脑内出血进行全基因组的关联研究，其中包括相当一部分具有ICH的少数族裔。一项全基因组关联研究评估了具有数十万个标记的DNA，以识别与ICH风险更大或更少有关的区域或基因。但是，当前的建议将无法完成此类分析，因为目前数字不足。因此，当前提案的目标是：1）了解对黑人和西班牙裔ICH最重要的风险因素； 2）确定种族/种族的大脑图像差异； 3）确定介导种族/种族介导结果差异差异的因素； 4）确定来自不同地区或国籍的西班牙裔和非裔美国人（例如墨西哥，古巴等）是否在遗传上有所不同。为了实现这些目标，我们有11个招聘中心，代表美国各地的30家招聘医院，其中大量的非裔美国人和西班牙裔人口。还将招募来自同一地区的白色ICH病例，以说明风险因素的区域差异以及风险因素，结果和成像差异的比较组。将开发一个集中式神经影像中心，以与乔治敦大学一起在马萨诸塞州综合医院对电影进行统一阅读和分析。将在迈阿密人类基因组学研究所开发用于集中式DNA处理和样品处理的生物座席。 Wake Forest University将开发数据和统计中心。这项研究的主要优点是研究人员的经验，尤其是招募少数族裔人群以及对ICH和流行病学的特别兴趣；案例，风险因素和集中分析的统一定义；以及识别和招募研究所需的大量受试者的能力。