Recovery of StrokE - Longitudinal Assessment With Neuroimaging (ROSE LAWN)

StrokE 的恢复 - 神经影像纵向评估 (ROSE LAWN)

• 批准号: 10542718
• 负责人: Daniel Woo
• 金额: $ 75.2万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10542718
• 关键词: Acute; Address; Affect; African American population; Age; Ancillary Study; Atrophic; Behavioral; Biological Markers; Blinded; Blood Vessels; Brain hemorrhage; Budgets; CASP2 gene; Cerebral Amyloid Angiopathy; Cerebral hemisphere hemorrhage; Cerebral small vessel disease; Chronic; Clinical assessments; Cognitive; Contralateral; DNA; Data; Deferoxamine; Dementia; Deterioration; Development; Diffusion Magnetic Resonance Imaging; Disabled Persons; Enrollment; Evaluation; Funding; Gene Expression; Hemorrhage; Hemosiderin; Hypertension; Image; Impaired cognition; Incidence; Inflammation; Inflammatory; Inflammatory Response; Interleukin-8; Iron Chelating Agents; Lacunar Infarctions; Leukocytes; Longterm Follow-up; Magnetic Resonance Imaging; Measurement; Measures; Mediation; Microvascular Dysfunction; Minority; Molecular Genetics; Motor; Outcome; Patients; Phenotype; Population; Prevention; Principal Investigator; Prospective Studies; RNA; Recording of previous events; Recovery; Reporting; Risk; Risk Factors; Role; Sampling; Serum; Siderosis; Statistical Data Interpretation; Stroke; Supratentorial; Survivors; United States National Institutes of Health; Variant; White Matter Disease; cohort; dementia risk; disability; follow-up; high risk; inflammatory marker; multidisciplinary; neuroimaging; neuroimaging marker; novel; patient population; programs; recruit; stroke recovery; tractography; transcriptome sequencing

Program Director/Principal Investigator (Last, First, Middle): Woo, Daniel; Anderson, Christopher 3. Project Summary/Abstract We have recently completed analyses which identifies a population of patients that have a markedly increased risk of developing dementia/progressive cognitive impairment. Intracerebral hemorrhage patients had been reported to have a 42% risk of progressive cognitive impairment roughly 3 and a half years after their stroke and we have found a 39% risk in an independent population of patients. This extraordinarily high rate among survivors of ICH without a prior history of dementia yields multiple different hypotheses. First, it may be that the causes of ICH itself are also risk factors for dementia. If so, then those that develop dementia should demonstrate worsening markers of these causes such as cerebral small vessel disease and cerebral amyloid angiopathy. However, another prominent hypothesis in the field is that the hemorrhage itself is markedly inflammatory. If this inflammatory response were to trigger a progressive cognitive decline, then these cases should demonstrate differential inflammatory gene expression changes. The Recovery of StrokE (NS100417) study has recruited 163 cases out of a planned 500 total cases of ICH including 3T MRI, baseline and 3 month samples for DNA, RNA-sequencing and detailed baseline, 3 and 6 month motor, cognitive, behavioral and functional examinations. The current proposal seeks to re-enroll 250 cases of the planned 500 for 12 to 24 month follow-up neuroimaging, RNA sampling and repeated examination measures to address the following aims: 1) Determine if progressive cognitive impairment correlates with an increase in markers of cerebral small vessel disease and cerebral amyloid angiopathy; 2) Determine if inflammation as measured by RNA-sequencing markers of inflammation correlates with progressive cognitive impairment and 3) identify novel neuroimaging markers associated with progressive cognitive decline. If successful, we will provide the largest longitudinal multiple assessment evaluation of ICH and answer the major hypotheses on the development of dementia among survivors of ICH. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

计划主任/首席调查员（最后，第一，中间）：Daniel Woo；安德森，克里斯托弗 3。项目摘要/摘要 我们最近完成了分析，该分析确定了一群明显的患者 增加痴呆症/进行性认知障碍的风险增加。脑内出血患者患有 据报道，他们中风后大约3年半的渐进认知障碍风险42％ 我们发现独立患者人群的风险为39％。这个极高的速度 ICH的幸存者没有先前的痴呆症史产生多种不同的假设。首先，可能是 ICH本身的原因也是痴呆症的危险因素。如果是这样，那么那些发展痴呆的人应该证明 这些原因的标记恶化，例如脑小血管疾病和脑淀粉样血管病。 但是，该领域的另一个突出假设是出血本身显着炎症。如果这个 炎症反应是为了引发渐进的认知下降，然后这些情况应证明 差异炎症基因表达变化。 中风的恢复（NS100417）研究已从计划的500例ICH中招募了163例 包括3T MRI，基线和3个月的DNA样本，RNA测序和详细的基线，3和6 月运动，认知，行为和功能检查。当前的提议试图重新注册250 计划500的病例为12至24个月的随访神经影像学，RNA采样和重复检查 解决以下目的的措施：1）确定渐进认知障碍是否与 脑小血管疾病和脑淀粉样血管病的标记增加； 2）确定是否 通过炎症的RNA再生标记来测量的炎症与进行性认知相关 损伤和3）确定与进行性认知下降有关的新型神经影像标记。 如果成功，我们将提供最大的纵向多重评估评估，并回答 ICH幸存者中痴呆症发展的主要假设。 PHS 398/2590（修订版06/09）页面延续格式页面