Stroke Central Atlantic Network for Research (SCANR)

中风中央大西洋研究网络 (Scanr)

• 批准号: 10850004
• 负责人: BARBARA S BREGMAN
• 金额: $ 3.73万
• 依托单位: MEDSTAR HEALTH RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10850004
• 关键词: Acute; Adult; African American; Arteries; Baltimore; Biological Markers; Black race; Blood Vessels; Brain; Cerebral Amyloid Angiopathy; Cerebrum; Cervical; Child; Childhood; Childhood stroke; Clinical; Disparity; Dissection; Doctor of Philosophy; Eligibility Determination; Enrollment; Extramural Activities; Fellowship Program; Funding; Genetic; Health Disparities Research; Historically Black Colleges and Universities; Hospitals; Image; Institution; Intervention; Leadership; Link; Magnetic Resonance Imaging; Maryland; Medical center; Mentored Clinical Scientist Development Program; Mentorship; Mid-Atlantic Region; Multimodal Imaging; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Patient Recruitments; Patients; Persons; Phase; Phenotype; Play; Positioning Attribute; Prevention; Prevention trial; Process; Productivity; Registries; Rehabilitation therapy; Reporting; Research; Research Institute; Research Personnel; Research Training; Residencies; Robotics; Role; Scientist; Site; Stroke; Stroke Belt; StrokeNet trials; Training; Translating; Translational Research; Underserved Population; Universities; Venous Thrombosis; Virginia; Washington; acute stroke; career; career development; cerebrovascular; experience; innovation; microbiome research; multidisciplinary; multimodality; multiple omics; neurological rehabilitation; news; novel; participant retention; patient population; programs; recruit; rehabilitation research; research and development; rural setting; screening; stroke incidence; stroke patient; stroke rehabilitation; stroke trials; treatment trial; urban setting

FROM ORIGINAL PROPOSAL: SCANR, the Stroke Central Atlantic Network for Research is based in the Mid- Atlantic region and headquartered in Washington, DC, and Charlottesville, VA. SCANR is located on the edge of the Stroke Belt, and both DC and Baltimore have high stroke incidence. SCANR includes four Carnegie Research 1 universities (Georgetown and George Washington Universities; the Universities of Virginia and Maryland), two CTSAs, a translational research institute (THRIV), a US News & World Report National Honor Roll Hospital (Children's National Medical Center), the largest hospital in DC (MedStar Washington Hospital Center), two Historically Black Universities (Howard University and University of DC) and the NINDS Intramural Stroke Program. SCANR sites evaluated over 4100 acute strokes in 2016, >50% were Black/African American. Our NINDS-funded trial recruitment is excellent, screening all eligible patients for and enrolling in StrokeNet trials: DEFUSE 3, MISTIE 3, HiDef, Rhapsody, SHINE, POINT, and MR WITNESS, along with additional NINDS-funded trials. SCANR also includes the National Coordinating Center for SHINE (UVa, Johnston-PI), and the CREST-2 registry and imaging core (UMB, Lal). SCANR 2.0 continues to have all of the excellent qualities that made SCANR 1.0 a strong contender for StrokeNet selection: pediatric stroke and stroke rehabilitation, patient populations and innovative recruitment practices for health disparities research, and the link to the NINDS Intramural Stroke Program. These strengths will stand out with the pediatric, rehab, and pediatric rehab trials in the StrokeNet pipeline. SCANR 2.0 includes UVa as a high-performing site for acute treatment and prevention trials. UVa also provides expertise in biomarkers, genetics, and prehospital research. The addition of UVa and UMB made SCANR a truly regional Coordinating Center. SCANR 2.0 research expertise includes multimodal imaging, microbiomics, multi-omics, Neurorehabilitation trials, brain stimulation, and robotics. We are well positioned to translate early phase NINDS intramural studies into the extramural setting. We have a track record of recruiting substantial numbers of specific cerebrovascular phenotypes (cervical artery dissection, cerebral venous thrombosis, cerebral amyloid angiopathy, etc.). Our consortium of academic rehab hospitals is outstanding. We currently have four trial proposals submitted to StrokeNet in varying stages of the process. Our existing Participant Recruitment and Retention Core (PRRO Core) has played a leadership role in the StrokeNet network. SCANR investigators serve on national StrokeNet steering committees and cores. Our StrokeNet fellows have diverse clinical backgrounds (2 vascular neurologists, 1 PT PhD, 1 OT) and subsequently, they successfully compete for external funding (TL-2, KL-2, AHA). They have opportunities for outstanding research training and mentorship across our Mid- Atlantic institutions, preparing them for productive research careers. SCANR investigators recently successfully established a novel national K12 program for rehabilitation research. We currently have 5 relevant fellowship programs and three adult neurology residencies at the SCANR 2.0 sites. This training joins strong multidisciplinary clinical and research expertise in stroke with much experience in research and career development of clinician scientists.

根据原始提案：Scanr，中风中央大西洋研究网络基于中间 大西洋地区，总部位于华盛顿特区和弗吉尼亚州夏洛茨维尔。 Scanr位于 中风带，DC和巴尔的摩的中风发生率很高。 Scanr包括四个卡内基研究1 大学（乔治敦和乔治华盛顿大学；弗吉尼亚州和马里兰州的大学），两个CTSA，一个 美国新闻与世界报告国家荣誉榜（儿童国家）翻译研究所（THRIV）（THRIV） 医疗中心），华盛顿特区最大的医院（Medstar Washington Hospital Center），两所历史悠久的黑人大学 （霍华德大学和华盛顿大学）和Ninds壁内中风计划。 2016年评估了超过4100次急性中风的SCANR站点，> 50％是黑人/非裔美国人。我们的Ninds资助的审判 招聘非常出色，筛查所有合格的患者并参加拼写器试验：Duduse 3，Mistie 3，Hidef， 狂想曲，闪耀，点和证人先生，以及其他由Ninds资助的审判。扫描还包括 国家闪光协调中心（UVA，Johnston-Pi）和Crest-2注册表和成像核心（UMB，LAL）。 Scanr 2.0继续具有使Scanr 1.0成为Strotenet的强大竞争者的所有优质品质 选择：儿科中风和中风康复，患者人群和健康招聘实践 差异研究以及与Ninds壁内中风计划的链接。这些优势将在 街道管道中的儿科，康复和小儿康复试验。 Scanr 2.0包括UVA作为高性能站点 用于急性治疗和预防试验。 UVA还提供了生物标志物，遗传学和院前研究的专业知识。 UVA和UMB的添加使Scanr成为真正的区域协调中心。 SCANR 2.0研究专业知识包括多模式成像，微生物学，多词，神经康复试验，大脑 刺激和机器人技术。我们在将早期ninds内壁内研究转化为壁外的好处 环境。我们有招募大量特定脑血管表型的记录（颈动脉 解剖，脑静脉血栓形成，脑淀粉样血管病等）。我们的学术康复医院财团是 杰出的。目前，我们有四项在此过程的阶段提交给Strokenet的审判提案。我们的现有 参与者的招聘和保留核心（PRRO CORE）在Strokenet网络中发挥了领导作用。 扫描仪调查人员在国家拼写物转向委员会和核心任职。我们的Strokenet研究员有多样化 临床背景（2位血管神经科医生，1 pt Phd，1 OT），随后，它们成功地争夺外部 资金（TL-2，KL-2，AHA）。他们有机会在我们的中期进行出色的研究培训和指导 大西洋机构为生产研究职业做准备。 Scanr调查人员最近成功 建立了一项新型的国家K12康复研究计划。我们目前有5个相关奖学金计划 SCANR 2.0站点的三个成人神经病学驻留。该培训加入了强大的多学科临床和 中风的研究专业知识在临床科学家的研究和职业发展方面具有丰富的经验。