Neurorehabilitation and Restorative Neuroscience Network

神经康复和恢复神经科学网络

• 批准号: 9405068
• 负责人: BARBARA S BREGMAN
• 金额: $ 77.22万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9405068
• 关键词: Basic Science; Benchmarking; Chronic; Clinical; Clinical Research; Clinical Trials; Complex; Development Plans; Discipline; Disease; Doctor of Philosophy; Faculty; Funding; General Hospitals; Geography; Grant; Health Occupations; Health system; Hospitals; Individual; Institutes; Interdisciplinary Study; Leadership; Manuscripts; Maryland; Massachusetts; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Mission; Nervous System Trauma; Nervous system structure; Neurorehabilitation; Neurosciences; Outcome; Patients; Phase; Population; Positioning Attribute; Productivity; Recovery; Recovery of Function; Recruitment Activity; Rehabilitation therapy; Research; Research Personnel; Research Training; SECTM1 gene; Science; Site; Technology; TimeLine; Training; Translating; Travel; United States National Institutes of Health; Universities; Vocational Guidance; Writing; base; career development; coping; disability; educational atmosphere; effective intervention; health care delivery; nervous system disorder; new technology; programs; translational neuroscience

The paucity of NIH-funded Phase III rehabilitation clinical trials is prima facie evidence that, despite multiple cycles of taxpayer funding, the incumbent K12 programs have fallen short in their mission of translating science into treatments for patients. We emphasize the K12 RFA’s first Background sentence: “Despite the increasing population of individuals coping with chronic disabilities at various levels, the field of medical rehabilitation has not responded sufficiently to the need for research to validate approaches, optimize treatments, and incorporate new technologies and opportunities.” Existing programs are inwardly focused and mired in supporting historical academic and clinical silos. They do not prioritize the research needs of patients or the training needed to develop investigators equipped to overcome complex disabling disorders. We intend a different approach. First, we will include all clinical disciplines, and simply recruit the best scholars. Second, we will focus on a single group of disorders: disabling chronic neurological disorders. Thus, we target a multilevel scientific approach (from molecules to outcomes), all directed at the problem of nervous system recovery and not a clinical credential. Third, we will blend the best of old and new by pairing excellent and traditional university-based training settings with more contemporary excellent healthcare delivery training settings based in nonprofit health systems. Fourth, we have assembled a leadership team composed of successful translational neuroscience/neurorehabilitation investigators with a track record of interdisciplinary research training. These individuals are national leaders, and each has a wide network for recruiting scholars and mentors nationally. Finally, we increase efficiency by reducing travel barriers with a geographically compact network and maximize trainee productivity by including an executive coaching program. Alexander Dromerick, MD and Barbara Bregman, PT, PhD are Program Directors. The coordinating site is Georgetown University and affiliated National Rehabilitation Hospital. Other primary sites: John Hopkins /Kennedy Krieger Institute (Bastian), Harvard (Schlaug), Massachusetts General Hospital Institute of Health Professions (Connor), Massachusetts Institute of Technology (Krebs), University of Maryland/Kernan (Wittenberg), and Cornell/Burke Rehabilitation Hospital (Ratan). We will provide the strongest possible interdisciplinary mentorship and training for the early career development of these K12 scholars from all neurorehabilitation disciplines in an educational environment that promotes strong interactions between basic and clinical research to develop effective interventions to promote functional recovery after neurological injuries. We will support 4 faculty scholars yearly,(2-3 years each); they will remain engaged in the K12 program activities for 5 years as they transition to independent faculty positions. Together with their local primary mentor, each scholar develops an individual career development plan that includes research training, coursework, manuscript and grant writing support with specific timelines and benchmarks for progress.

NIH资助的III阶段康复临床试验的稀少是Prima Facie的证据，表明，多皮特 现任K12计划的多个纳税人资金的多个周期都在他们的任务中缺乏 将科学转化为患者的治疗方法。我们强调K12 RFA的第一个背景句子： “尽管在各种层面上应对慢性疾病的个体人口增加，但 医疗康复尚未对研究的需求做出正确的反应，以验证方法，优化 治疗，并纳入新技术和机会。 陷入支持历史学术和临床孤岛。他们没有优先考虑患者的研究需求 或开发配备有能力克服复杂残疾疾病的调查人员所需的培训。 我们打算采取不同的方法。首先，我们将包括所有临床学科，并简单地招募最好的 学者。其次，我们将重点关注一组疾病：致残慢性神经系统疾病。那， 我们针对多层次科学方法（从分子到结果），全部针对神经问题 系统恢复，而不是临床证书。第三，我们将通过配对优秀的新旧融合在一起 和传统的基于大学的培训环境，并具有更现代的出色医疗保健培训 基于非营利性卫生系统的设置。第四，我们组建了一个由 成功的翻译神经科学/神经康复调查员，具有跨学科的记录 研究培训。这些人是国家领导人，每个人都有一个广泛的网络来招募学者 和全国范围的导师。最后，我们通过在地理上降低旅行障碍来提高效率 通过包括执行教练计划，紧凑的网络和最大的学员生产率。 医学博士亚历山大·德罗梅里克（Alexander Dromerick）和PT Barbara Bregman博士是计划导演。协调 现场是乔治敦大学和会员国家康复医院。其他主要网站：约翰·霍普金斯 /肯尼迪·克里格研究所（Bastian），哈佛大学（施洛格），马萨诸塞州综合医院卫生研究院 马萨诸塞州科技研究所（KREBS）的专业人士（康纳），马里兰大学/克南大学 （维滕贝格）和康奈尔/伯克康复医院（拉坦）。我们将提供强大的可能 这些K12学者的早期职业发展的跨学科思想和培训 在教育环境中，神经居住学科促进基本之间的牢固互动 和临床研究以开发有效的干预措施，以促进神经系统的功能恢复 受伤。我们将每年支持4位教职学者（每年2 - 3年）；他们将继续参与K12 在过渡到独立教师职位时，计划活动5年。和他们的当地人一起 主要导师，每个学校的发展都有一个个人职业发展计划，其中包括研究培训， 课程，手稿和赠款写作支持，并提供特定的时间表和基准进行进度。