Gallium Based Mechanically Adaptable Microelectrode Arrays

镓基机械适应性微电极阵列

• 批准号: 10057878
• 负责人: HUANAN ZHANG
• 金额: $ 41.94万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10057878
• 关键词: Affect; Basic Science; Benchmarking; Biomedical Research; Body Temperature; Buffers; Chronic; Clinical; Clinical Research; Development; Devices; Diffuse; Dimensions; Electrodes; Electrophysiology (science); Environment; Failure; Foreign Bodies; Gallium; Glass; Implant; Implantation procedure; Inflammation; Lesion; Liquid substance; Longevity; Measurement; Mechanics; Metals; Microelectrodes; Modeling; Modulus; Motor Cortex; Neurologic; Outcome; Performance; Physiological; Polymers; Procedures; Process; Property; Rattus; Research; Rodent Model; Signal Transduction; Silicon; Solid; Structure; Study models; System; Temperature; Testing; Thick; Time; Tissues; Utah; base; biomaterial compatibility; brain tissue; density; design; electric impedance; electrical property; flexibility; fundamental research; improved; in vivo; innovation; manufacturing process; mechanical properties; melting; next generation; pressure; response; seal; tool

Project Summary: Next Generation Mechanically Adaptable Microelectrode Implantable microelectrodes are essential tools for understanding basic electrophysiology. Although considerable progress has been made in the past several decades in terms of electrode design, the current devices are still unable to retain their functionalities in a physiological environment over long periods, due to failure is related to the staggering mismatch between the mechanical properties of the electrodes and tissue. There have been significant research efforts in the development of flexible implantable electrodes. However, the flexible electrode will buckle during insertion and require rigid shuttle/coating to penetrate the targeted issue The complications of tissue insertion has significantly hindered the practical usage of the flexible implantable electrodes. In this project, we will take an innovative material approach to develop a new class of thermo-responsive and mechanically adaptable microelectrode between room temperature and physiological temperature. We will harness the unique thermal/mechanical/electrical properties of gallium to design a mechanically adaptable electrode array. Gallium has a unique melting point of 29.36 °C at 1 atm pressure. This indicates gallium will be a rigid solid at room temperature (Young's modulus of 10 GPa) and a liquid (no mechanical strength) at body temperature. We aim to develop a thermal drawing process to create gallium/polymer core-shell structure and assemble the structures into microelectrode array. We will assess the mechanical properties, electrochemical performance, in vivo signal recording ability, and biocompatibility of the gallium-based microelectrode arrays.

项目摘要：下一代机械适应性微电极 植入式微电极是了解基本电生理学的重要工具。 在过去的几十年里，电极设计方面取得了长足的进步，目前 由于以下原因，设备仍然无法在生理环境中长期保留其功能： 故障与电极和组织的机械性能之间的惊人不匹配有关。 然而，在柔性植入电极的开发方面已经做出了大量的研究工作。 柔性电极在插入过程中会弯曲，并且需要刚性梭子/涂层才能穿透目标 问题 组织插入的并发症严重阻碍了柔性柔性支架的实际使用 在这个项目中，我们将采用创新的材料方法来开发一类新的电极。 室温和生理温度之间的热响应和机械适应性微电极 我们将利用镓独特的热/机械/电特性来设计一个 机械适应性电极阵列在 1 个大气压下具有 29.36 °C 的独特熔点。 这表明镓在室温下是刚性固体（杨氏模量为 10 GPa）和液体（无 我们的目标是开发一种热拉伸工艺来创造。 我们将评估镓/聚合物核壳结构并将该结构组装成微电极阵列。 机械性能、电化学性能、体内信号记录能力和生物相容性 镓基微电极阵列。