Imaging Biomarker Core

成像生物标志物核心

• 批准号: 10662489
• 负责人: EMILY J ROGALSKI
• 金额: $ 78.17万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662489
• 关键词: Achievement; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Biological Markers; Biomedical Engineering; Clinical; Cognitive; Collaborations; Data; Data Set; Databases; Dedications; Dementia; Diagnostic; Differential Diagnosis; Discipline of Nuclear Medicine; Eligibility Determination; Ensure; Extramural Activities; Functional Imaging; Funding; Future; Goals; Heterogeneity; High Performance Computing; Hospitals; Image; Impaired cognition; Individual; Infrastructure; Institution; Magnetic Resonance Imaging; Methods; Mission; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Natural History; Output; PET/CT scan; Participant; Phase; Phenotype; Positron-Emission Tomography; Process; Radiology Specialty; Records; Research; Research Personnel; Research Project Grants; Resources; Running; Scanning; Structure; Translational Research; Universities; amnestic mild cognitive impairment; cluster computing; cohort; data archive; data integration; data management; falls; image translation; imaging biomarker; imaging modality; improved; molecular imaging; multimodal neuroimaging; neuroimaging; quality assurance; recruit; statistics; structural imaging; tool; training opportunity

PROJECT SUMMARY - IMAGING BIOMARKER CORE The Northwestern ADRC Imaging Biomarker Core has the long-term goal to characterize all eligible Clinical Core participants with state-of-the-art structural, functional, and molecular imaging and curate these data for use in future projects. The Northwestern ADRC Clinical Core currently maintains a cohort of over 500 participants. Approximately half of the Clinical Core Participants receive systematic MR imaging funded by R01s from NIA, NINDS, and NIDCD. During the last cycle, the Imaging Biomarker Core increased imaging coverage from approximately 50% of the Clinical Core cohort to nearly 70%. For the next cycle, it will acquire and process structural, functional, and molecular imaging on additional Clinical Core participants who are not covered by other research grants and who are targeted for relevant collaborative studies. We will use advanced acquisition and analysis methods and ensure these data are integrated with other variables within an infrastructure that supports intramural and extramural collaborations and provides rich opportunities for training. The Imaging Biomarker Core is highly interconnected with the other Northwestern ADRC Cores in a manner that enhances the missions of NAPA and the NIA. It will be guided by the following goals: 1) Acquire systematic and multimodal neuroimaging (MR, PET) on Clinical Core participants who lack these biomarkers and who are eligible/recruited for collaborative studies we support. To this end, Clinical Core participants including cognitively healthy controls, individuals with amnestic mild cognitive impairment (aMCI), and individuals with AD/ADRD will be scanned with advanced PET and MR imaging modalities. 2) Curate and share integrated imaging datasets on Clinical Core participants, which will serve intramural and extramural collaborations including REC trainee projects. This aim will draw upon a mature institutional computing structure to run pipelines for quality assurance, processing, and analysis of imaging data. The resulting imaging outputs will be incorporated with clinical and post-mortem data in our unified ADRC NeuroFiles database developed in collaboration with the Data Management and Statistics Core. The infrastructure of the Imaging Biomarker Core includes two research-dedicated 3T Siemens MR magnets at Northwestern’s Center for Translational Imaging (CTI) and a PET/CT scanner at Northwestern Memorial Hospital. Data are directly routed from the scan console to the Northwestern University Neuroimaging Data Archive (NUNDA), where quality assurance and analysis tools are launched with the support of a high- performance computing cluster called QUEST. Collectively, these data will enhance the clinical and diagnostic characterization of each Clinical Core participant and will be made available to approved intramural and national collaborators including NACC. All phases of this proposal will offer unique opportunities for the training of junior investigators in areas related to imaging and translational research.

项目摘要 - 成像生物标志物核心 西北ADRC成像生物标志物核心的长期目标是表征所有符合条件的临床 具有最先进的结构，功能和分子成像的核心参与者，并策划这些数据 在未来的项目中使用。西北ADRC临床核心目前维持500多个队列 参与者。大约一半的临床核心参与者接受了由 来自NIA，NINDS和NIDCD的R01。在最后一个周期中，成像生物标志物核心增加成像 从临床核心队列的大约50％到几乎70％的覆盖范围。对于下一个周期，它将获得 以及对非其他临床核心参与者的过程结构，功能和分子成像 由其他研究补助金涵盖，并针对相关的协作研究。我们将使用 高级获取和分析方法，并确保将这些数据与其他变量集成 支持壁内和壁外合作的基础设施，并为 训练。成像生物标志物核与A中的其他西北ADRC核高度互连 增强纳帕和尼亚的任务的方式。它将以以下目标为指导： 1）获得缺乏这些的临床核心参与者的系统和多模式神经影像学（MR，PET） 生物标志物，并有资格/招募我们支持的合作研究。为此，临床核心 参与者包括认知健康对照，患有柔滑的轻度认知障碍的人 （AMCI），并且具有AD/ADRD的个人将被先进的PET和MR成像方式扫描。 2）在临床核心参与者上策划和共享集成的成像数据集，该数据将服务于壁内 以及包括REC培训人员项目在内的壁外合作。这个目标将借鉴成熟的机构 计算结构以运行管道来进行质量保证，处理和分析成像数据。 最终的成像输出将与我们的统一ADRC中纳入临床和验尸数据 Neurofiles数据库与数据管理和统计核心合作开发。 成像生物标志物核心的基础架构包括两个研究的3T SIEMENS MR磁铁 西北转化成像中心（CTI）和西北纪念馆的宠物/CT扫描仪 医院。数据直接从扫描控制台路由到西北大学神经影像数据 档案馆（Nunda），在高质量保证和分析工具的支持下， 性能计算集群称为任务。总的来说，这些数据将增强临床和诊断 每个临床核心参与者的表征，并将可用于批准的壁内和 包括NACC在内的国家合作者。该提案的所有阶段将为培训提供独特的机会 在与成像和翻译研究有关的领域的初级研究人员的工作。