Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research

癌症生物学多联盟协调中心（MC2 中心）：建立跨学科科学社区、协调有影响力的资源共享并推进癌症研究

• 批准号: 10525124
• 负责人: Julie Ann Bletz
• 金额: $ 198.03万
• 依托单位: SAGE BIONETWORKS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-14 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10525124
• 关键词: Address; Advanced Malignant Neoplasm; Area; Benchmarking; Biomedical Research; Cancer Biology; Cancer Center; Collaborations; Communication; Communities; Data; Data Commons; Deposition; Division of Cancer Biology; Education and Outreach; Educational workshop; Effectiveness; Ensure; Evaluation; FAIR principles; Fostering; Funding; Glues; Hybrids; Knowledge; Knowledge Portal; Malignant Neoplasms; Modeling; Outcomes Research; Persons; Research Personnel; Resource Sharing; Resources; Science; Scientist; Software Tools; System; Systems Biology; Training; Validation; Work; anticancer research; community building; community engagement; data harmonization; data sharing; data tools; diversity and inclusion; evidence base; experience; ideation; improved; informatics infrastructure; innovation; interdisciplinary approach; interdisciplinary collaboration; interoperability; meetings; metadata standards; next generation; outreach; program dissemination; programs; public repository; special interest group; success; tool; translational cancer research; usability; working group

Project Summary Systems Biology has been an instrumental approach to overcoming challenges in biomedical research, where solutions arise from interdisciplinary efforts, shared resources (data, tools, models, expertise) and integrative analyses. The NCI Division of Cancer Biology (DCB) has created multiple consortia comprising interdisciplinary communities of scientists who aim to integrate approaches, data, and tools to address important questions in basic and translational cancer research. The Multi-Consortia Coordinating (MC2) Center for Cancer Biology will work across programs to motivate engagement and collaboration, support resource sharing, and disseminate knowledge and resources to the broader scientific community. The MC2 Center will operate through three hubs. The Collaboration Hub will use evidence-based strategies to catalyze interactions and new collaborations. An evaluation framework will be developed with quantitative and qualitative metrics to ensure the center continuously improves its impact. Community engagement activities will include working groups, special interest groups, DREAM Challenges, and Ideation Jams, all of which will have mechanisms for ensuring inclusion and promoting diversity. To facilitate sharing of resources from DCB programs, the Resource Coordination Hub will ensure all resources are findable, accessible, interoperable and reusable (FAIR); it will identify or develop open and FAIR standards and best practices; provide training on how to implement these standards and practices in the cancer research community; and provide tooling and interfaces to facilitate resource sharing, curation, and deposition in public repositories. Finally, the Outreach Hub will enhance dissemination of knowledge and resources through training materials to maximize utilization of tools and short courses and workshops that bring concepts and resources from across the DCB programs together, enabling the broader community to experience the power of an integrative interdisciplinary approach to cancer. The Cancer Complexity Knowledge Portal will continue to provide open access to all data, tools, and other resources generated through the DCB and MC2, highlighting discoveries and enabling exploration into the many valuable resources generated by DCB programs.

项目摘要 系统生物学一直是克服生物医学研究中挑战的一种工具性方法， 解决方案来自跨学科的工作，共享资源（数据，工具，模型，专业知识）和集成 分析。 NCI癌症生物学分部（DCB）创建了包括跨学科的多个财团 旨在整合方法，数据和工具以解决重要问题的科学家社区 基础和转化癌研究。癌症生物学中心（MC2）多康斯比特氏菌协调中心将 跨计划努力，以激励参与和协作，支持资源共享和传播 知识和资源给更广泛的科学界。 MC2中心将通过三个枢纽运行。协作中心将使用基于证据的策略来 催化互动和新的合作。评估框架将以定量和 定性指标以确保该中心不断改善其影响。社区参与活动将 包括工作组，特殊兴趣小组，梦想挑战和构思果酱，所有这些都将拥有 确保包容和促进多样性的机制。促进DCB的资源共享 程序，资源协调中心将确保所有资源都可以找到，可访问，可互操作，并且 可重复使用（公平）；它将识别或制定开放和公平的标准和最佳实践；提供培训 如何在癌症研究界实施这些标准和实践；并提供工具和 促进公共存储库中资源共享，策划和沉积的界面。最后，宣传 集线器将通过培训材料增强知识和资源的传播，以最大化利用 在DCB计划中带来概念和资源的工具，简短的课程和研讨会 共同使更广泛的社区体验综合跨学科方法的力量 癌症。 癌症复杂性知识门户将继续为所有数据，工具和其他数据提供公开访问 通过DCB和MC2生成的资源，突出发现发现并探索 DCB计划产生的许多有价值的资源。