Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

了解癌症的种族差异：多种族队列研究

• 批准号: 10523441
• 负责人: Christopher Alan Haiman
• 金额: $ 246.74万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10523441
• 关键词: African American population; Aliquot; Anthropometry; Bayesian Modeling; Biological Markers; Blood; Blood specimen; Calibration; California; Cessation of life; Chemicals; Chronic Disease; Clinical; Cohort Studies; Computerized Medical Record; Consultations; Cost efficiency; Cryopreservation; Cultural Diversity; Custom; Data; Data Analyses; Data Management Resources; Data Security; Data Set; Databases; Diagnosis; Diagnostic; Dietary intake; Disease Outcome; Energy Intake; Energy Metabolism; Ensure; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Risk Factor; Epigenetic Process; Ethnic group; Etiology; Funding; Genetic; Genetic Risk; Genomics; Genotype; Geographic Locations; Grant; Hawaii; Health; Health behavior; Hospitals; Incidence; Indirect Calorimetry; Infrastructure; Intake; Japanese American; Japanese Population; Latino Population; Leadership; Life Style; Lymphocyte; Maintenance; Malignant Neoplasms; Measurement; Measures; Medical; Medicare/Medicaid; Methodology; Native Hawaiian; Neighborhoods; Normal tissue morphology; Online Systems; Oral; Outcome; Paper; Participant; Phenotype; Physical activity; Physiological; Pilot Projects; Planning Techniques; Postdoctoral Fellow; Prospective cohort study; Publishing; Questionnaires; Registries; Research; Research Methodology; Research Personnel; Research Project Grants; Residual state; Resources; Rest; Risk Factors; Saliva; Sampling; Science; Slide; Social Environment; Specimen; Structural Racism; Students; System; Testing; Tissue Banks; Tissue Sample; Training; Tumor Tissue; United States National Institutes of Health; Urine; Vertebral column; Vital Statistics; Woman; actigraphy; biobank; blood product; climate change; cohort; complex data; computerized; data harmonization; data sharing; database of Genotypes and Phenotypes; design; dietary; dietary supplements; digital repositories; disorder prevention; epigenomics; ethnic difference; ethnic diversity; ethnic health disparity; ethnic minority; follow-up; genetic risk factor; genome wide association study; health equity; improved; indexing; innovation; member; men; metabolomics; microbiome research; multi-ethnic; neoplasm registry; novel strategies; nutrition; programs; prospective; racial and ethnic; racial and ethnic disparities; racial diversity; social health determinants; stool sample; tumor; tumor registry; willingness

This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the investigators in nutrition, ethnic/racial disparities studies, and genetics. It is the most ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by significantly supplementing active follow-up information with computerized linkages to SEER cancer registries, vital statistics, hospital-discharge diagnoses, medical claim data, electronic medical records and geospatial information. At baseline, the cohort included information on 215,000 men and women, comprised almost entirely of five ethnic/racial populations: Japanese Americans, Latinos, Whites, African Americans and Native Hawaiians. The resource was later expanded to include a prospective biorepository of blood specimens from ~70,000 of the participants and urine specimens on a large subset. Leadership of the MEC entails a highly interactive, team-science approach, and the investigators have amply demonstrated their willingness to share data/samples, and to participate actively in consortia. Research accomplishments include significant contributions to understanding both genetic and environmental risk factors for cancer. Over 291 papers describing our findings have been published during the current grant cycle. In addition, over the last 28 years, 129 NIH grants/supplements have been built around the MEC (77 were active in the current cycle), and more than 136 students and postdoctoral fellows have been trained on the study. This application describes our aims over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research. We project adding 7,253 incident cancer cases in the new 5 years, to the current 48,064 cases; 2,670 of these cases will have pre-diagnostic blood samples, to be added to the current 10,957 cases. We will add 6K FFPE tumor samples to the current ~13K. In addition, this grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating lifestyle, environmental, and genetic risk factors and social determinants of health for cancer and other common chronic diseases, taking advantage of new approaches, such as dietary quality indices, exposomics, genomics, epigenomics, microbiomics, metabolomics and multilevel exposures, including spatial environment, structural racism, and climate change. The MEC will allow the testing of innovative research hypotheses aimed at ensuring that racial/ethnic health disparities are investigated and that progress in disease prevention applies to all major US racial/ethnic minorities.

该更新应用程序寻求支持多民族队列（MEC）研究的基础设施，这是 1993 - 1996年在夏威夷和南加州成立，研究癌症和其他慢性的危险因素 疾病。该研究旨在利用两个地理的种族和文化多样性 领域以及研究人员在营养，种族/种族差异研究和遗传学方面的专业知识。它 是存在最多样化的癌症队列。它通过显着实现高成本效率 通过与SEER癌症注册表的计算机链接补充主动的后续信息，至关重要 统计，医院诊断，医疗索赔数据，电子病历和地理空间 信息。在基线时，该队列包括有关215,000名男女的信息，几乎包括 完全由五个种族/种族人口：日裔美国人，拉丁美洲人，白人，非裔美国人和本地人 夏威夷人。后来扩展了该资源，包括从 〜70,000个参与者和尿液标本在大子集中。 MEC的领导需要高度 互动，团队科学方法，调查人员充分表明了他们分享的意愿 数据/样本，并积极参与财团。研究成就包括重大 了解癌症的遗传和环境风险因素的贡献。超过291篇论文 描述我们的发现已在当前赠款周期中发表。此外，在过去的28年中， 在MEC附近建造了129个NIH赠款/补充剂（当前周期中有77个活性），更多 超过136名学生和博士后研究员接受了这项研究的培训。此应用程序描述了我们的 在接下来的5年中，目标是维护和增强MEC的基础设施以及计划 方法论研究。我们预测在新的5年中增加了7,253例事件癌病例， 48,064例；这些情况中有2,670个将有诊断前的血液样本，将添加到当前的10,957 案例。我们将在当前〜13K中添加6K FFPE肿瘤样品。此外，此赠款续签将做出 旨在评估生活方式，环境， 以及癌症和其他常见慢性疾病健康的遗传危险因素和社会决定因素， 利用新方法，例如饮食质量指数，外博学，基因组学，表观基因组学， 微生物学，代谢组学和多层次暴露，包括空间环境，结构性种族主义和 气候变化。 MEC将允许测试创新的研究假设，以确保 研究了种族/种族健康差异，预防疾病的进展适用于美国全美国主要 种族/族裔少数民族。