Multidisciplinary Training in Ethnic Diversity and Cancer Disparities

种族多样性和癌症差异的多学科培训

• 批准号: 10132262
• 负责人: Christopher Alan Haiman
• 金额: $ 48.35万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10132262
• 关键词: Training; cancer health disparity; ethnic diversity; multidisciplinary

At the root of health disparities is the diversity in the biological, social, cultural, behavioral, and economic characteristics of individuals and populations. The study of ethnic/racial disparities begins with an understanding of the characteristics of each group and how these characteristics affect cancer development and outcomes. This new application for a joint T32 postdoctoral training program at University of Hawaii Cancer Center (UHCC) and the University of Southern California (USC) Norris Comprehensive Cancer Center (NCCC) addresses cancer health disparities utilizing a unique resource, the Multiethnic Cohort (MEC) Study, a population-based prospective cohort study that has followed African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites for the past 25 years. Linkages to cancer registries, Medicare, and other data sources provide a variety of endpoints for MEC and many other cancer disparity studies conducted at both institutions. The complementary research at UHCC and USC is supported by cutting edge cores and benefits from many years of experience. The specific aims of the proposed training program are: 1. To train postdoctoral fellows for independent careers in cancer research in diverse populations, with a specific focus on the sociocultural, nutritional, lifestyle and biological risk factors leading to cancer health disparities in a variety of ethnic/racial minorities. This program is highly unique and will leverage the long- standing (30+ years) collaboration between research programs at two NCI-designated Cancer Centers to permit a broader experience in training and tools for epidemiological research. 2. To provide extensive applied research experience in a multidisciplinary environment focusing on nutritional, molecular, genetic and translational epidemiology that builds on multiple unique racial and ethnically diverse studies of cancer. Together with strong mentorship, these studies will serve as the centerpiece for an effective transdisciplinary training, which will allow trainees to design innovative high-impact projects, and will prepare trainees for careers in cancer health disparities research. During the 5-year grant period, the training program will educate 8 postdoctoral fellows in Hawaii and 10 in Los Angeles. All trainees will be exposed to a wide range of innovative molecular and traditional cancer prevention approaches (epidemiology, biomarkers, genomics, and nutrition) to address a wide range of cancer disparity research questions across the ethnic/racial populations in Hawaii and California through the close cooperation of mentors in both locations and regular exchange visits. The dual-site training, which regular includes exchange visits, is a particular strength of the proposed training program as it will provide exposure to multi- institutional and multi-disciplinary collaborative research that builds on the expertise and long-standing collaboration between UH and USC in research, education and training.

健康差异的根源是生物、社会、文化、行为和经济方面的多样性 个人和群体的特征。对民族/种族差异的研究始于 了解每个群体的特征以及这些特征如何影响癌症的发展 和结果。夏威夷大学联合T32博士后培训项目的新申请 癌症中心 (UHCC) 和南加州大学 (USC) 诺里斯综合癌症中心 (NCCC) 利用独特的资源——多种族队列 (MEC) 研究来解决癌症健康差异问题，该研究是一项 基于人群的前瞻性队列研究，跟踪非裔美国人、夏威夷原住民、日本人 过去 25 年里的美国人、拉丁裔和白人。与癌症登记、医疗保险和其他数据的链接 来源提供了 MEC 和在这两个国家进行的许多其他癌症差异研究的各种终点 机构。 UHCC 和 USC 的互补研究得到尖端核心和优势的支持 根据多年的经验。拟议培训计划的具体目标是： 1. 培养在不同人群中独立从事癌症研究的博士后研究员， 特别关注导致癌症健康的社会文化、营养、生活方式和生物风险因素 各种族裔/少数族裔之间的差异。该计划非常独特，并将利用长期 两个 NCI 指定癌症中心的研究项目之间长期（30 多年）合作 允许在流行病学研究的培训和工具方面获得更广泛的经验。 2. 在多学科环境中提供广泛的应用研究经验，重点关注营养、 建立在多个独特种族和民族基础上的分子、遗传和转化流行病学 癌症的多样化研究。加上强有力的指导，这些研究将成为 有效的跨学科培训，使学员能够设计创新的高影响力项目， 并将帮助学员为癌症健康差异研究的职业做好准备。 在5年资助期内，该培训计划将在夏威夷培养8名博士后研究员，在洛杉矶培养10名博士后研究员。 安吉利斯。所有学员都将接触到广泛的创新分子和传统癌症预防 解决广泛的癌症差异的方法（流行病学、生物标志物、基因组学和营养） 通过密切合作，研究夏威夷和加利福尼亚州各族裔/种族人口的问题 两地导师并定期互访。双地点培训，定期包括 互访是拟议培训计划的一个特殊优势，因为它将提供接触多方面的机会 以专业知识和长期经验为基础的机构和多学科合作研究 夏威夷大学和南加州大学在研究、教育和培训方面的合作。