Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study - Diversity Supplement

了解癌症的种族差异：多种族队列研究 - Diversity Supplement

• 批准号: 10747120
• 负责人: Christopher Alan Haiman
• 金额: $ 3.86万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747120
• 关键词: African American population; Blood specimen; California; Chronic Disease; Cohort Studies; Computerized Medical Record; Cost efficiency; Cultural Diversity; Data; Diagnosis; Diagnostic; Ensure; Environment; Environmental Risk Factor; Ethnic Origin; Ethnic Population; Etiology; Genetic; Genomics; Geographic Locations; Grant; Hawaii; Hospitals; Infrastructure; Japanese American; Latino Population; Leadership; Life Style; Maintenance; Malignant Neoplasms; Medical; Native Hawaiian; Paper; Participant; Planning Techniques; Postdoctoral Fellow; Publishing; Race; Research; Research Methodology; Research Personnel; Resources; Risk Factors; Sampling; Science; Specimen; Structural Racism; Students; Testing; Training; United States National Institutes of Health; Urine; Vital Statistics; Woman; biobank; climate change; cohort; computerized; data sharing; design; dietary; disorder prevention; epigenomics; ethnic difference; ethnic disparity; ethnic diversity; ethnic health disparity; ethnic minority; follow-up; genetic risk factor; indexing; innovation; men; metabolomics; microbiome research; multi-ethnic; neoplasm registry; novel strategies; nutrition; parent grant; programs; prospective; racial disparity; racial diversity; racial health disparity; racial minority; racial population; social health determinants; tumor; willingness

Abstract – Parent Grant This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the investigators in nutrition, ethnic/racial disparities studies, and genetics. It is the most ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by significantly supplementing active follow-up information with computerized linkages to SEER cancer registries, vital statistics, hospital-discharge diagnoses, medical claim data, electronic medical records and geospatial information. At baseline, the cohort included information on 215,000 men and women, comprised almost entirely of five ethnic/racial populations: Japanese Americans, Latinos, Whites, African Americans and Native Hawaiians. The resource was later expanded to include a prospective biorepository of blood specimens from ~70,000 of the participants and urine specimens on a large subset. Leadership of the MEC entails a highly interactive, team- science approach, and the investigators have amply demonstrated their willingness to share data/samples, and to participate actively in consortia. Research accomplishments include significant contributions to understanding both genetic and environmental risk factors for cancer. Over 291 papers describing our findings have been published during the current grant cycle. In addition, over the last 28 years, 129 NIH grants/supplements have been built around the MEC (77 were active in the current cycle), and more than 136 students and postdoctoral fellows have been trained on the study. This application describes our aims over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research. We project adding 7,253 incident cancer cases in the new 5 years, to the current 48,064 cases; 2,670 of these cases will have pre- diagnostic blood samples, to be added to the current 10,957 cases. We will add 6K FFPE tumor samples to the current ~13K. In addition, this grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating lifestyle, environmental, and genetic risk factors and social determinants of health for cancer and other common chronic diseases, taking advantage of new approaches, such as dietary quality indices, exposomics, genomics, epigenomics, microbiomics, metabolomics and multilevel exposures, including spatial environment, structural racism, and climate change. The MEC will allow the testing of innovative research hypotheses aimed at ensuring that racial/ethnic health disparities are investigated and that progress in disease prevention applies to all major US racial/ethnic minorities.

摘要 - 父母赠款 该更新应用程序寻求支持多民族队列（MEC）研究的基础设施，这是 1993 - 1996年在夏威夷和南加州成立，研究癌症和其他慢性的危险因素 疾病。该研究旨在利用两个地理的种族和文化多样性 领域以及研究人员在营养，种族/种族差异研究和遗传学方面的专业知识。 是存在最多样化的癌症队列。它通过显着实现高成本效率 补充与SEER癌症注册表的计算机链接，重要的随访信息，重要的统计数据， 医院诊断，医疗索赔数据，电子病历和地理空间信息。 基线，该队列包括有关215,000名男女的信息，几乎全部由5个组成 种族/种族人口：日裔美国人，拉丁美洲人，白人，非裔美国人和夏威夷原住民。这 后来扩展了资源，以包括约70,000个血液标本的前瞻性生物标本。 参与者和尿液标本在大子集中。 MEC实体的领导能力高度互动，团队 - 科学方法，调查人员充分证明了他们愿意共享数据/样本，并且 积极参与财团。研究成就包括对理解的重要贡献 癌症的遗传和环境风险因素。超过291篇描述我们发现的论文已经 在当前赠款周期中发布。此外，在过去的28年中，有129个NIH赠款/补品有 建于MEC周围（当前周期中有77个活跃），超过136名学生和博士后 研究员已经接受了这项研究的培训。该申请描述了我们未来5年的目标 并增强MEC的基础设施以及方法论研究计划。我们项目添加 在新的5年中，有7,253例癌症病例，目前为48,064例；这些案件中有2,670个将有前 诊断血液样本，将添加到当前的10,957例病例中。我们将在 当前〜13k。此外，这种赠款的续签将使能够延续一个整合的计划 旨在评估生活方式，环境和遗传危险因素以及健康决定者的研究 用于癌症和其他常见的慢性疾病，利用新方法，例如饮食质量 索引，外博学，基因组学，表观基因组学，微生物学，代谢组学和多层次暴露，包括 空间环境，结构性种族主义和气候变化。 MEC将允许测试创新研究 旨在确保研究种族/种族健康差异的假设 预防适用于美国所有主要的种族/族裔少数民族。