Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study - Diversity Supplement

了解癌症的种族差异：多种族队列研究 - Diversity Supplement

• 批准号: 10747120
• 负责人: Christopher Alan Haiman
• 金额: $ 3.86万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747120
• 关键词: African American population; Blood specimen; California; Chronic Disease; Cohort Studies; Computerized Medical Record; Cost efficiency; Cultural Diversity; Data; Diagnosis; Diagnostic; Ensure; Environment; Environmental Risk Factor; Ethnic Origin; Ethnic Population; Etiology; Genetic; Genomics; Geographic Locations; Grant; Hawaii; Hospitals; Infrastructure; Japanese American; Latino Population; Leadership; Life Style; Maintenance; Malignant Neoplasms; Medical; Native Hawaiian; Paper; Participant; Planning Techniques; Postdoctoral Fellow; Publishing; Race; Research; Research Methodology; Research Personnel; Resources; Risk Factors; Sampling; Science; Specimen; Structural Racism; Students; Testing; Training; United States National Institutes of Health; Urine; Vital Statistics; Woman; biobank; climate change; cohort; computerized; data sharing; design; dietary; disorder prevention; epigenomics; ethnic difference; ethnic disparity; ethnic diversity; ethnic health disparity; ethnic minority; follow-up; genetic risk factor; indexing; innovation; men; metabolomics; microbiome research; multi-ethnic; neoplasm registry; novel strategies; nutrition; parent grant; programs; prospective; racial disparity; racial diversity; racial health disparity; racial minority; racial population; social health determinants; tumor; willingness

Abstract – Parent Grant This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the investigators in nutrition, ethnic/racial disparities studies, and genetics. It is the most ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by significantly supplementing active follow-up information with computerized linkages to SEER cancer registries, vital statistics, hospital-discharge diagnoses, medical claim data, electronic medical records and geospatial information. At baseline, the cohort included information on 215,000 men and women, comprised almost entirely of five ethnic/racial populations: Japanese Americans, Latinos, Whites, African Americans and Native Hawaiians. The resource was later expanded to include a prospective biorepository of blood specimens from ~70,000 of the participants and urine specimens on a large subset. Leadership of the MEC entails a highly interactive, team- science approach, and the investigators have amply demonstrated their willingness to share data/samples, and to participate actively in consortia. Research accomplishments include significant contributions to understanding both genetic and environmental risk factors for cancer. Over 291 papers describing our findings have been published during the current grant cycle. In addition, over the last 28 years, 129 NIH grants/supplements have been built around the MEC (77 were active in the current cycle), and more than 136 students and postdoctoral fellows have been trained on the study. This application describes our aims over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research. We project adding 7,253 incident cancer cases in the new 5 years, to the current 48,064 cases; 2,670 of these cases will have pre- diagnostic blood samples, to be added to the current 10,957 cases. We will add 6K FFPE tumor samples to the current ~13K. In addition, this grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating lifestyle, environmental, and genetic risk factors and social determinants of health for cancer and other common chronic diseases, taking advantage of new approaches, such as dietary quality indices, exposomics, genomics, epigenomics, microbiomics, metabolomics and multilevel exposures, including spatial environment, structural racism, and climate change. The MEC will allow the testing of innovative research hypotheses aimed at ensuring that racial/ethnic health disparities are investigated and that progress in disease prevention applies to all major US racial/ethnic minorities.

摘要 – 家长资助 此更新申请寻求对多种族队列 (MEC) 研究基础设施的支持，该研究是 1993-1996 年在夏威夷和南加州成立，旨在研究癌症和其他慢性病的危险因素 该研究旨在利用两个地理区域的种族和文化多样性。 领域，以及研究人员在营养、民族/种族差异研究和遗传学方面的专业知识。 是现有种族最多样化的癌症队列，它通过显着实现了高成本效益。 通过与 SEER 癌症登记处、生命统计的计算机化链接来补充主动随访信息， 出院诊断、医疗索赔数据、电子病历和地理空间信息。 基线时，该队列包含 215,000 名男性和女性的信息，几乎全部由五名男性组成 民族/种族人口：日裔美国人、拉丁裔、白人、非裔美国人和夏威夷原住民。 该资源后来得到扩展，包括一个前瞻性生物储存库，其中包含来自大约 70,000 个血液样本的血液样本。 MEC 的领导需要高度互动的团队。 科学方法，研究人员充分证明了他们分享数据/样本的意愿，并且 积极参与联盟的研究成果包括对理解的重大贡献。 超过 291 篇论文描述了我们的发现。 此外，在过去 28 年中，NIH 已获得 129 项资助/补充。 围绕 MEC 建立（77 名活跃于当前周期），超过 136 名学生和博士后 研究员已经接受了该研究的培训。该应用程序描述了我们未来 5 年维护的目标。 加强 MEC 的基础设施，以及方法研究的计划。 新五年内将有 7,253 例癌症病例增加到目前的 48,064 例，其中 2,670 例将接受预防治疗； 诊断血液样本，将添加到当前的 10,957 例病例中 我们将添加 6K FFPE 肿瘤样本。 目前约 13K 此外，这笔赠款续订将使一个完善的综合计划得以继续。 旨在评估生活方式、环境和遗传风险因素以及健康的社会决定因素的研究 针对癌症和其他常见慢性病，利用新方法，例如饮食质量 指数、暴露组学、基因组学、表观基因组学、微生物组学、代谢组学和多级暴露，包括 MEC 将允许测试创新研究。 旨在确保种族/族裔健康差异得到调查以及疾病进展的假设 预防适用于美国所有主要种族/族裔。