Neural Mechanisms of Song vs Speech Production: Insights from Aphasia and Intracranial Recording

歌曲与言语产生的神经机制：失语症和颅内记录的见解

• 批准号: 10648716
• 负责人: Nina F. Dronkers
• 金额: $ 22.85万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10648716
• 关键词: Address; Affect; Aphasia; Aphasia Tests; Area; Behavior; Behavioral; Behavioral Mechanisms; Bilateral; Brain; Brain Injuries; Brain imaging; Brain region; Broca Aphasia; Clinical; Communication; Complement; Dissociation; Electroencephalography; Epilepsy; Excision; Fiber; Frequencies; Impairment; Implanted Electrodes; Individual; Inferior frontal gyrus; Knowledge; Language; Language Therapy; Left; Lesion; Methodology; Methods; Modality; Motor; Neuroanatomy; Participant; Pathway interactions; Patients; Pattern; Performance; Persons; Population; Production; Retrieval; Site; Speech; Speech Therapy; Standardization; Stimulus; Structure; System; Techniques; Testing; Time; cohort; gray matter; innovation; insight; lexical retrieval; neural; neural patterning; neuromechanism; neurophysiology; neurosurgery; novel; patient population; post stroke; recruit; spatiotemporal; stroke survivor; stroke-induced aphasia; syntax; tool; tractography; white matter

Project Summary/Abstract Despite extensive exploration into the neural mechanisms of language, there is no conclusive explanation for why language expression through song is spared relative to speech in certain individuals with aphasia. To investigate this phenomenon, the current study takes an innovative approach in examining how the brain expresses language through song versus speech. We will define behavioral patterns and the structural and functional neuroanatomy of singing, merging evidence from two distinct patient cohorts and two different methodologies: individuals with post-stroke aphasia (n=30), and neurosurgical patients with implanted electrodes (n=20). Both cohorts will be tested on the same set of speech and language tasks with different processing demands: motor speech, word retrieval, and a sentence priming task. Each task will be presented in both spoken and sung modalities. In participants with aphasia, we will analyze error patterns and inspect damaged neural structures associated with specific performance profiles, while in the neurosurgical cohort, the analysis will shift to temporal dynamics and sites of activity underlying each task. The novel combination of behavioral and lesion analysis in people with aphasia and intracranial electroencephalography (iEEG) in neurosurgical patients will provide unique insights into the behavioral and neural mechanisms of singing. We will first determine which aspects of spoken language are expressed more fluently in song than in speech by people with aphasia with different profiles of impairment. Second, we will identify which gray matter structures and fiber pathways support the ability to produce utterances in song. Contrasting spared and damaged brain areas between those who do better with singing and those who do not will outline regions in the left hemisphere that are critical for sung speech production. Identifying fiber pathways uniquely spared between the two groups will provide further information about which structural connections support sung vs. spoken speech production. Third, we will determine the broadband high-frequency neural activity (HFA; 70-150 Hz) of spoken versus sung language production. We will use iEEG recordings from neurosurgical patients and compare differences in neural activity during singing and speaking as they complete the same three speech and language tasks. This will complement the previous lesion and tractography analyses by also examining right hemisphere regions and intra- and interhemispheric communication between regions involved in spoken and sung language production. Overall, the novel combination of these two methods for investigating song vs speech production using the same set of speech and language tasks has never been accomplished before and will shed new light on the dissociation between these two systems, outlining distinct behavioral patterns, neural mechanisms, and temporal dynamics. The clinical implications are considerable for targeted speech and language therapy for stroke survivors as well as other clinical populations who have language production deficits.

项目摘要/摘要 尽管对语言的神经机制进行了广泛的探索，但没有结论性的解释 对于某些失语症的某些人的语音，通过歌曲的语言表达是为何幸免的。到 研究这种现象，当前的研究采用了一种创新的方法来检查大脑 通过歌曲与语音表达语言。我们将定义行为模式以及结构性和 唱歌的功能性神经解剖学，从两个不同的患者队列中合并了证据和两个不同的证据 方法论：触觉后失语症（n = 30）和植入电极的神经外科患者 （n = 20）。这两个队列将在具有不同处理的同一组语音和语言任务上进行测试 需求：电动语音，单词检索和句子启动任务。每个任务都将在两个说话中呈现 和演唱的方式。在失语症的参与者中，我们将分析错误模式并检查受损的神经 与特定性能曲线相关的结构，而在神经外科群体中，分析将改变 到每项任务基础的时间动力学和活动站点。行为和病变的新颖组合 神经外科患者的失语症和颅内脑电图（IEEG）的分析将 提供有关唱歌的行为和神经机制的独特见解。 我们将首先确定歌曲中的哪些方面比语音更流利 患有失语症的人具有不同的损害。其次，我们将确定哪些灰质结构 纤维途径支持在歌曲中产生话语的能力。对比鲜明的大脑和受损的大脑 那些在唱歌方面做得更好的人与那些没有做的人会概述左半球的区域 这对于演唱语音产生至关重要。识别两组之间独特幸免的纤维途径 将提供有关哪些结构连接支持Sung vs.口语演讲生产的进一步信息。 第三，我们将确定口语与演唱的宽带高频神经活动（HFA； 70-150 Hz） 语言生产。我们将使用神经外科患者的IEEG记录并比较神经的差异 唱歌和说话期间的活动完成相同的三个语音和语言任务。这会 通过检查右半球区域和 涉及口语和演唱语言产生的地区之间的内膜和半球间沟通。 总体而言，这两种用于调查歌曲与语音生产的方法的新颖组合使用相同 言语和语言任务集以前从未完成，并将为 这两个系统之间的解离，概述了不同的行为模式，神经机制和时间。 动力学。临床意义对于中风的有针对性的语音和语言疗法是相当大的 幸存者以及其他具有语言产生缺陷的临床人群。