Neural Mechanisms and Recovery of Language Production Deficits in Aphasia

失语症语言产生缺陷的神经机制和恢复

基本信息

批准号：
10669501
负责人：
Nina F. Dronkers
金额：
$ 0.36万
依托单位：
EAST BAY INSTITUTE FOR RESEARCH AND EDUC
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-09 至 2018-06-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10669501
关键词：
Affect American Aphasia Area Behavioral Brain Brain Injuries Brain imaging Brain region Characteristics Communication Contralateral Craniocerebral Trauma Diffuse Diffusion Diffusion Magnetic Resonance Imaging Disease Evaluation Exhibits Fiber Image Imaging Device Imaging Techniques Impairment Individual Injury Language Language Disorders Lesion Longitudinal Studies Magnetic Resonance Imaging Measurable Measurement Measures Modification Monitor Neurologic Neurons Outcome Participant Pathway interactions Patients Pattern Performance Persons Play Production Prognosis Quality of life Recovery Resolution Site Speech Stroke Structure Symptoms Techniques Testing Thick Time accurate diagnosis base common symptom density disability effective therapy gray matter indexing insight morphometry multimodal neuroimaging myelination neuroimaging neuromechanism novel optimal treatments post stroke prevent reconstruction relating to nervous system skills social engagement stroke-induced aphasia time interval tool tractography treatment strategy white matter white matter damage

项目摘要

Aphasia is a common outcome following brain injury and often leads to long-term disability and diminished quality of life. Language production disorders in particular, such as difficulty finding the right word or problems speaking in sentences, are the most common symptoms of aphasia, and significantly hinder communication and social participation. While some people with language production deficits recover well during the first year after injury, others will not, and this discrepancy in outcomes is largely unpredictable. Many factors affect recovery patterns across individuals, one of which is the involvement of different neuroanatomical structures in the resulting impairment and subsequent degree of recovery. Surprisingly, little is known about structural changes in the brain accompanying recovery from language production deficits in aphasia, though preliminary evidence suggests they may be better predictors of recovery than traditionally-used functional change measures. The proposed longitudinal, multimodal neuroimaging study will explore the patterns of recovery in a large group of individuals with aphasia following stroke. By combining a number of novel techniques, we will investigate the contributions of numerous gray and white matter structures to the recovery of language production deficits. Fifty individuals with aphasia will be tested at 1-, 3- and 12-months post stroke on various measures of language production at the word, sentence and discourse level to establish baseline measures of performance and monitor changes across the different stages of recovery. At the same three time points, participants will undergo structural MRI and high angular resolution diffusion imaging (HARDI) to determine lesion site, white matter integrity, and changes in grey and white matter over time. The first main objective of the study is to determine which damaged cortical regions and white matter pathways impede recovery of language production throughout the first year. The second main objective is to measure neuronal changes in gray matter morphometry and white matter integrity that accompany observed behavioral improvement. Evaluating different time periods during the first year post-stroke will enable us to tease out neural indices predicting, impeding, and supporting language recovery at different stages. The proposed project will be the first comprehensive longitudinal study using state-of-the art techniques to examine plasticity within gray matter regions and white matter tracts and their contribution to recovery of different language levels over the course of one full year. In the end, the results of this study will provide important insights into factors contributing to successful recovery of language abilities and enable clinicians to utilize neuroimaging information in prognosis and selection of the most optimal treatments.

失语症是脑损伤后的常见结果，常常导致长期残疾和生活质量下降。特别是语言产生障碍，例如难以找到正确的单词或在句子中说话的问题，是失语症最常见的症状，并且严重阻碍沟通和社会参与。虽然一些有语言能力缺陷的人恢复得很好在受伤后的第一年，其他人不会，而且这种结果的差异在很大程度上是不可预测的。许多影响个体恢复模式的因素之一是不同神经解剖学的参与由此产生的损害和随后的恢复程度的结构。令人惊讶的是，人们对此知之甚少然而，随着失语症语言产生缺陷的恢复，大脑的结构发生变化初步证据表明，与传统使用的功能性指标相比，它们可能是更好的康复预测指标。改变措施。拟议的纵向、多模式神经影像研究将探索患者的恢复模式一大群中风后患有失语症的人。通过结合多种新颖的技术，我们将研究众多灰质和白质结构对语言恢复的贡献生产赤字。将在中风后 1、3 和 12 个月对 50 名失语症患者进行各种测试在单词、句子和话语层面对语言产生进行测量，以建立基线测量性能并监控不同恢复阶段的变化。同时三个时间点，参与者将接受结构 MRI 和高角分辨率扩散成像 (HARDI) 以确定病变部位、白质完整性以及灰质和白质随时间的变化。该研究的第一个主要目标是确定哪些皮质区域和白质受损路径阻碍了整个第一年语言能力的恢复。第二个主要目标是测量伴随观察到的灰质形态测量和白质完整性的神经元变化行为改善。评估中风后第一年的不同时间段将使我们能够梳理出在不同阶段预测、阻碍和支持语言恢复的神经指标。拟议的项目将是第一个使用最先进技术的综合纵向研究检查灰质区域和白质束内的可塑性及其对恢复的贡献一整年的不同语言水平。最后，本研究的结果将提供对有助于成功恢复语言能力的因素的重要见解并使临床医生能够利用神经影像信息进行预后和选择最佳治疗。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke.

DOI：
10.1016/j.bandl.2021.105057
发表时间：
2022-01
期刊：
Brain and language
影响因子：
2.5
作者：
Zyryanov A;Stupina E;Gordeyeva E;Buivolova O;Novozhilova E;Akinina Y;Bronov O;Gronskaya N;Gunenko G;Iskra E;Ivanova E;Kalinovskiy A;Kliuev E;Kopachev D;Kremneva E;Kryuchkova O;Medyanik I;Pedyash N;Pozdniakova V;Pronin I;Rainich K;Reutov A;Samoukina A;Shlyakhova A;Sitnikov A;Soloukhina O;Yashin K;Zelenkova V;Zuev A;Ivanova MV;Dragoy O
通讯作者：
Dragoy O

The unique role of the frontal aslant tract in speech and language processing.

DOI：
10.1016/j.nicl.2022.103020
发表时间：
2022
期刊：
NEUROIMAGE-CLINICAL
影响因子：
4.2
作者：
Zhong, Allison J.;Baldo, Juliana, V;Dronkers, Nina F.;Ivanova, Maria, V
通讯作者：
Ivanova, Maria, V

The Russian Aphasia Test: The first comprehensive, quantitative, standardized, and computerized aphasia language battery in Russian.

DOI：
10.1371/journal.pone.0258946
发表时间：
2021
期刊：
PloS one
影响因子：
3.7
作者：
Ivanova MV;Akinina YS;Soloukhina OA;Iskra EV;Buivolova OV;Chrabaszcz AV;Stupina EA;Khudyakova MV;Akhutina TV;Dragoy O
通讯作者：
Dragoy O

A case of pure apraxia of speech after left hemisphere stroke: behavioral findings and neural correlates.