Transcranial alternating current stimulation to enhance language abilities

经颅交流电刺激增强语言能力

• 批准号: 10723719
• 负责人: Denise Y Harvey
• 金额: $ 10.86万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723719
• 关键词: Address; Adult; Affect; Aphasia; Basic Science; Behavior Therapy; Behavioral; Biological Markers; Brain; Brain region; Cephalic; Cognition Disorders; Communication; Coupling; Development Plans; Effectiveness; Elderly; Electric Stimulation; Electroencephalography; Exhibits; Foundations; Frequencies; Functional disorder; Genetic Complementation Test; Goals; Human; Impairment; Individual; Intervention; Knowledge; Language; Language Development; Language Disorders; Left; Life; Logistics; Measures; Mental disorders; Methodology; Methods; Mission; Motor; Names; Neuronal Plasticity; Neurons; Output; Pattern; Performance; Personal Satisfaction; Persons; Placebos; Procedures; Production; Public Health; Quality of life; Recovery; Rehabilitation therapy; Research; Research Personnel; Residual state; Role; Severities; Short-Term Memory; Stroke; System; Task Performances; Techniques; Therapeutic; Time; Training; Treatment outcome; United States; United States National Institutes of Health; Work; aphasia recovery; brain dysfunction; career development; chronic stroke; clinical investigation; cognitive process; cost effective intervention; disability; effective intervention; improved; improved outcome; innovation; language comprehension; language impairment; language processing; motor impairment; nervous system disorder; neural; neuromechanism; neurophysiology; neuropsychiatric disorder; neuroregulation; noninvasive brain stimulation; novel; programs; recovery services; research and development; social; specific language impairment; standard of care; stroke rehabilitation; stroke survivor; stroke therapy; stroke-induced aphasia; support network; targeted treatment; therapy development; tool; translational research program

PROJECT SUMMARY/ABSTRACT Stroke represents the primary cause of adult disability in the United States. A frequent, debilitating consequence of stroke is impairments in the ability to produce and/or comprehend language, called aphasia, which has profound impacts on quality of life due to the barriers it places on participation in professional and social daily life activities. Behavioral intervention—the current standard-of-care—provide some benefit for persons with aphasia (PWA), but their effectiveness is variable due in part to logistic and financial limitations that render interventions with the level of frequency, intensity, and duration required for lasting benefits infeasible for many PWA. Thus, there is a need for novel, time- and cost-effective interventions to expedite and improve aphasia recovery. Transcranial alternating current stimulation (tACS) has emerged as a promising noninvasive brain stimulation technique that may enhance stroke-related disability (motor impairments) and other neurological and psychiatric disorders, but the potential for improving outcomes specifically for language impairment has not yet been explored. The career development and research plans of the proposed project will allow the candidate to establish a T2 translational research program as an independent investigator to systematically explore the potential for tACS to enhance treatment outcomes in individuals with stroke-induced language impairment. The career development plan will help expand the candidate’s research program to include basic and clinical investigations of tACS-induced plasticity and its potential to facilitate language abilities in unimpaired and impaired speakers. The research plan provides an empirical foundation for this research program by investigating the neurophysiological mechanism by which tACS promotes language performance enhancement. The long-term goal of this research is to develop effective intervention approaches for individuals with acquired language impairment by combining theoretically- and neurally-guided intervention with treatment-enhancing neuromodulation techniques. The main objective of this proposal is to establish a best-practice approach for using tACS to support impairments in spoken word production. The central hypothesis of this proposal is that tACS can enhance word production abilities by modulating endogenous neuronal activation patterns associated with language. The rationale for the proposed research is that understanding neurophysiological biomarkers of language impairment and tACS-induced changes in neuronal pattens of activation may help determine the most effective approach to enhancing stroke treatment outcomes while extending our basic science knowledge of how tACS modulates neural activity. The proposed research is significant because it will enable the development of intervention procedures that maximize recovery from acquired language impairment, combining targeted therapy with tACS to unmask the residual capacity neuroplasticity in chronic stroke survivors. The proposed research is relevant to the NIH’s mission pertaining to developing fundamental knowledge that will potentially help to reduce the burdens of human disability.

项目摘要/摘要 中风代表了美国成人残疾的主要原因。经常令人衰弱 中风的后果是产生和/或理解语言的能力的损害，称为失语症， 由于其参与专业和 社会日常生活活动。行为干预（当前的护理标准）为 失语症（PWA）的人，但其有效性是由于后勤和财务限制的部分原因 这种使干预措施以持久福利所需的频率，强度和持续时间的水平 对于许多PWA来说都是不可行的。那是需要新颖，时间和成本效益的干预措施来加快和 改善失语症的恢复。经颅交流电流刺激（TAC）已成为有望 非侵入性大脑刺激技术可能会增强中风相关的残疾（运动障碍）和 其他神经和精神疾病，但专门改善结果的潜力 尚未探索损害。拟议项目的职业发展和研究计划将 允许候选人作为独立研究者建立T2转化研究计划 系统地探索TAC的潜力增强中风诱导的个体的治疗结果 语言障碍。职业发展计划将有助于将候选人的研究计划扩展到 包括对TAC诱导的可塑性的基本和临床研究，并具有促进语言的潜力 不受影响和发言者的能力。研究计划为此提供了经验基础 研究计划通过研究TAC促进语言的神经生理机制 性能提高。这项研究的长期目标是开发有效的干预方法 对于具有获得性语言障碍的个人，通过结合理论和中性引导的干预措施 使用增强治疗的神经调节技术。该提议的主要目的是建立 使用TAC来支持口语生产中的损害的最佳实践方法。中央 该提议的假设是TACS可以通过调节内源性来增强单词生产能力 与语言相关的神经元激活模式。拟议研究的理由是 了解语言障碍的神经生理生物标志物和TAC诱导的神经元变化 激活的淡化可能有助于确定增强中风治疗结果的最有效方法 同时，我们扩展了有关TAC如何调节神经活动的基础科学知识。拟议的研究是 意义重大，因为它将能够开发干预程序，从而最大程度地恢复 获得的语言障碍，将靶向疗法与TAC相结合以揭示剩余能力 慢性中风存活中的神经可塑性。拟议的研究与NIH的使命有关 发展基本知识，有可能有助于减少人类残疾的伯纳斯。