Duke Environmental Analysis Laboratory

杜克大学环境分析实验室

基本信息

批准号：
10646272
负责人：
P. Lee Ferguson
金额：
$ 125万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-10 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10646272
关键词：
Administrative Coordination Aromatic Polycyclic Hydrocarbons Biological Chemical Exposure Chemicals Chronic Disease Collaborations Community Health Consultations Core Facility Data Development Devices Dust Environment Environmental Epidemiology Environmental Exposure Environmental Health Environmental Impact Environmental Pollutants Epidemiologist Experimental Designs Exposure to Flame Retardants Funding Future Health Human Individual Infrastructure Intervention Knowledge Laboratories Laboratory Research Leadership Link Mass Spectrum Analysis Measurement Measures Methods Office of Administrative Management Outcome Pesticides Populations at Risk Preparation Productivity Qualifying Quality of life Recording of previous events Research Research Personnel Research Support Resolution Resources Risk Sampling Science Scientist Services Silicones Soil Technical Expertise Technology Time Trace metal Training United States National Institutes of Health Universities Water air monitoring analytical method chemical threat data exchange disorder risk epidemiology study experience exposed human population exposure pathway improved innovation interest laboratory development new technology novel strategies persistent organic pollutants phthalates pollutant programs research study risk mitigation sample collection screening tool

项目摘要

The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental exposures on human health. This research is vital to understanding the links between chemical exposures and human health endpoints, knowledge which is essential in mitigating disease risk and improving quality of life. DEAL will be co-directed by Dr. Heather Stapleton, a trained environmental chemist and exposure scientist, and Dr. Lee Ferguson, a trained mass spectrometrist and environmental analytical chemist. Drs. Stapleton and Ferguson each have over 20 years of experience using mass spectrometry to detect and quantify contaminants in environmental samples and are pioneers in the fields of emerging contaminants, exposure science, and non-targeted analytical methods. The long-term objectives of the DEAL Hub are to: 1) provide consultation and advice to environmental health researchers to support human health studies ; 2) provide comprehensive and state-of-the-art analytical services to supporting environmental health research; and 3) develop new analytical methods for the quantitation of emerging contaminants of interest to environmental health community and develop new technologies and tools for characterizing the exposome. To meet these objectives, DEAL consists of three internal cores. The first is the Environmental Sample Analysis Core (ESAR) that will support exposomic researchers by providing services for project consultations, sample preparation, extraction, and quantitative analysis of contaminants in environmental media using three distinct sample laboratories, the Targeted Organic, Targeted Inorganic, and Untargeted Organic labs. Through these three Labs, ESAR and DEAL as a whole can provide comprehensive services for a wide variety of analytes and support a larger breadth of environmental health researchers. Second is the Developmental Core that will create new analytical methods for the quantitation of emerging contaminants and develop new technologies and tools for characterizing the exposome. Finally, the Deal Hub will provide administrative management and coordination with the ESAR and Developmental Cores through the Administrative Core. This Administrative Core will also serve as the liaison between the DEAL Hub and the broader HHEAR Network, with Dr. Heather Stapleton as its Director. The intense collaboration of ESAR, Developmental, and Administrative Cores of the DEAL Hub will facilitate more and higher quality exposomic research that is essential for continued understanding of risk mitigation and environmental health interventions in at-risk populations.

杜克大学环境分析实验室 (DEAL) 中心的目的是提供一整套分析服务，支持流行病学家和卫生研究人员开展重点研究环境暴露对人类健康的影响。这项研究对于理解之间的联系至关重要化学品暴露和人类健康终点、对于减轻疾病风险至关重要的知识和提高生活质量。 DEAL 将由经过培训的环境化学家 Heather Stapleton 博士共同领导和暴露科学家，以及受过训练的质谱仪和环境分析员 Lee Ferguson 博士化学家。博士。 Stapleton 和 Ferguson 均拥有 20 多年使用质谱分析的经验检测和量化环境样本中的污染物，是新兴领域的先驱污染物、暴露科学和非目标分析方法。该协议的长期目标中心的职责是：1）为环境健康研究人员提供咨询和建议，以支持人类健康研究； 2) 提供全面、最先进的分析服务以支持环境健康研究; 3) 开发新的分析方法来定量感兴趣的新兴污染物环境健康社区并开发用于表征暴露组的新技术和工具。到为了满足这些目标，DEAL 由三个内部核心组成。首先是环境样本分析核心（ESAR）将通过提供项目咨询、样品服务来支持暴露研究人员使用三种不同的方法对环境介质中的污染物进行制备、提取和定量分析样品实验室、目标有机实验室、目标无机实验室和非目标有机实验室。通过这些三个实验室、ESAR和DEAL作为一个整体，可以为多种分析物提供全面的服务并支持更广泛的环境健康研究人员。其次是发展核心创建新的分析方法来定量新兴污染物并开发新技术以及用于表征暴露组的工具。最后，交易中心将提供行政管理和通过行政核心与 ESAR 和发展核心进行协调。本行政 Core 还将与 Heather 博士一起充当 DEAL Hub 和更广泛的 HHEAR 网络之间的联络人斯泰普尔顿担任其董事。 ESAR、发展和行政核心的密切合作 DEAL Hub 将促进更多、更高质量的暴露组研究，这对于持续进行至关重要了解高危人群的风险缓解和环境健康干预措施。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Characterizing firefighter's exposure to over 130 SVOCs using silicone wristbands: A pilot study comparing on-duty and off-duty exposures.

DOI：
10.1016/j.scitotenv.2022.155237
发表时间：
2022-08-15
期刊：
SCIENCE OF THE TOTAL ENVIRONMENT
影响因子：
9.8
作者：
Levasseur, Jessica L.;Hoffman, Kate;Herkert, Nicholas J.;Cooper, Ellen;Hay, Duncan;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.

Monitoring Human Exposure to Organophosphate Esters: Comparing Silicone Wristbands with Spot Urine Samples as Predictors of Internal Dose.

DOI：
10.1021/acs.estlett.1c00629
发表时间：
2021-09-14
期刊：
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
影响因子：
10.9
作者：
Hoffman, Kate;Levasseur, Jessica L.;Zhang, Sharon;Hay, Duncan;Herkert, Nicholas J.;Stapleton, Heather M.
通讯作者：
Stapleton, Heather M.