Develpment Core

开发核心

基本信息

批准号：
10430119
负责人：
P. Lee Ferguson
金额：
$ 22.28万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-10 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10430119
关键词：
Address Air Algorithms Analytical Chemistry Biological Biological Markers Calibration Chemical Exposure Chemicals Client Complex Complex Mixtures Data Databases Detection Development Dust Environment Environmental Exposure Environmental Health Environmental Impact Environmental Pollution Epidemiologist Evolution Exposure to Furniture Goals Growth Health Human Individual Indoor environment Informatics Knowledge Laboratories Lead Leadership Logistics Mass Spectrum Analysis Measurement Measures Metadata Metals Methods Molecular Nature Organic Chemistry Outcome Pathway interactions Preparation Probability Process Property Protocols documentation Research Research Personnel Resolution Resources Sampling Serum Services Silicones Source Standardization Structure Techniques Technology Testing Time Urine Validation Work analytical method base computerized data processing data reduction design environmental chemical environmental stressor experience exposed human population improved innovation interest laboratory development method development novel open source organic contaminant pollutant sensor tandem mass spectrometry tool water environment

项目摘要

PROJECT ABSTRACT The purpose of the Duke Environmental Analysis Laboratory (DEAL) Hub is to offer a comprehensive suite of analytical services to support epidemiologists and health researchers conducting studies focusing on the impact of environmental exposures on human health. To this end, the DEAL Developmental Core will address challenges in both developing and standardizing analytical and data processing approaches for assessing health-relevant chemical exposures in relevant media. The Developmental Core will be led by Drs. Lee Ferguson and Gordon Getzinger, who both have significant experience in environmental analytical chemistry of organic and inorganic pollutants, advanced high resolution mass spectrometry techniques, and chemoinformatics. The Developmental Core consists of three specific aims to meet this overarching goal: 1) develop new methods for measuring emerging environmental chemicals of interest, in order to create a client- responsive framework for performing measurements of environmental chemicals in various environmental media; 2) develop novel tools for assessing personal exposure, and advancing holistic chemical exposure assessments; and 3) develop innovative approaches for identification of new environmental contaminants. By achieving these aims, the Developmental Core will embrace the synergistic nature of the DEAL Hub as a whole, collaborating closely with the Environmental Sample Analysis Resource (ESAR) team to enhance its services and deploy newly-developed and validated methods, with the intent to streamline, harmonize, and significantly advance the services provided by DEAL and the broader HHEAR Network.

项目摘要杜克大学环境分析实验室 (DEAL) 中心的目的是提供一整套分析服务，支持流行病学家和卫生研究人员开展重点研究环境暴露对人类健康的影响。为此，DEAL 发展核心将解决开发和标准化评估分析和数据处理方法面临的挑战相关介质中与健康相关的化学物质暴露。发展核心将由博士领导。李 Ferguson 和 Gordon Getzinger 在环境分析化学领域拥有丰富的经验有机和无机污染物，先进的高分辨率质谱技术，以及化学信息学。发展核心由三个具体目标组成，以实现这一总体目标：1) 开发测量感兴趣的新兴环境化学品的新方法，以创建客户- 用于在各种环境中执行环境化学品测量的响应框架媒体; 2) 开发新工具来评估个人暴露并推进整体化学品暴露评估； 3) 开发识别新环境污染物的创新方法。通过实现这些目标，发展核心将拥抱 DEAL Hub 作为一个与环境样本分析资源 (ESAR) 团队密切合作，以增强其服务并部署新开发和验证的方法，旨在简化、协调和显着推进 DEAL 和更广泛的 HHEAR 网络提供的服务。