THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT

手部自发皮质活动逐步提升 (PESCAH) 项目

基本信息

  • 批准号:
    10321801
  • 负责人:
  • 金额:
    $ 51.86万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-01-15 至 2023-01-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Although HIV-infected patients in the western world have a life expectancy near that of the general population, they are at a significantly elevated risk of developing HIV-associated neurocognitive disorders (HAND). Such disorders are the most common neurological complication of HIV disease, with prevalence estimates ranging from 35-70% of all HIV-infected patients, and research targeting such comorbidities has been identified as a top priority by the Office of AIDS Research (NOT-OD-15-137). While the mechanisms that underlie HAND are not well understood, numerous human neuroimaging studies have examined the brain regions that may be involved, and overall these studies have been largely successful in identifying the critical hubs and large-scale networks. However, many questions remain regarding basic circuit dysfunction within these brain regions, and consequently there is a clear and common need to further investigate the key physiological parameters that may underlie the development and progression of HAND, especially in the context of aging. It is well known that human cortical neurons exhibit spontaneous firing in the absence of incoming exogenous and endogenous input. Across a neuronal population, these discharges summate with local dendritic currents and synaptic potentials to produce cortical rhythmic activity, which is often referred to as “spontaneous activity.” Such spontaneous rhythms are ubiquitous throughout the human brain, but their role in modulating cognition is only beginning to be understood. Recently, we used magnetoencephalography (MEG) to show that the strength of spontaneous activity directly affects neural oscillatory activity in the same cortical area, and in-turn modulates real time task performance in controls and HIV-infected adults. Additionally, we have shown that spontaneous activity in multiple brain regions increases with advancing age, that this increase is deleterious to performance, and that these effects are accentuated in patients with HAND. In fact, our preliminary data suggests that the level of spontaneous activity in specific brain regions may distinguish age-matched HIV-infected patients with and without HAND. In this project, we will quantify the trajectory of age-related elevations in spontaneous cortical activity in a large group of HIV-infected adults and demographically-matched controls. We will then evaluate how the strength of such spontaneous activity affects local neural oscillations and real time cognitive performance. Based on extensive preliminary data, we hypothesize that spontaneous activity will increase with age in both groups, and that the slope of this increase will be steeper in HIV-infected adults relative to controls, and further accentuated in those with HAND. Importantly, we also hypothesize that these increases will be associated with proportional changes in the strength of the neural oscillations underlying cognition, and behavioral performance indices such as accuracy and reaction time. Finally, in Aim 3, we will utilize deep learning methods to classify our sample into groups based on the neurophysiological metrics derived from MEG, with the gold standard being their overall neuropsychological profile.
项目摘要/摘要 尽管西方世界的艾滋病毒感染患者的预期寿命接近一般人口,但 它们正处于发展与HIV相关的神经认知障碍(HAND)的风险显着升高。这样的 疾病是HIV疾病最常见的神经系统并发症,患病率估计为 从35-70%的所有HIV感染患者中,针对此类合并症的研究已被确定为 艾滋病研究办公室(NOT-OD-15-137)的首要任务。虽然手是基于手的机制 不太了解的是,许多人类神经影像学研究检查了可能是大脑区域 参与其中,总的来说,这些研究在很大程度上成功地识别了关键枢纽和大规模的枢纽 网络。但是,关于这些大脑区域内基本电路功能障碍的许多问题以及 因此,有明显而普遍的需求,需要进一步研究关键的生理参数 可能是手的发展和进步,尤其是在衰老的背景下。 众所周知,在没有传入的外源性的情况下,人皮质神经元表现出发育 和内源性输入。在神经元种群中,这些排放用局部树突流总结 以及产生皮质节奏活性的突触潜力,通常称为“自发活性”。 这种赞助的节奏在整个人的大脑中无处不在,但它们在调节认知中的作用是 才开始被理解。最近,我们使用磁脑摄影(MEG)表明了强度 赞助活动的直接影响同一皮质区域的神经振荡活性,并进行调节 控制和感染HIV的成年人中的实时任务性能。另外,我们已经证明了赞助 多个大脑区域的活动随着年龄的增长而增加,这种增加被删除为性能, 并且这些作用在手动患者中得到了强调。实际上,我们的初步数据表明 特定大脑区域的赞助活动水平可能会区分年龄匹配的HIV感染患者 而且没有手。在这个项目中,我们将量化赞助的年龄相关高程的轨迹 大量艾滋病毒感染的成年人和人口统计学匹配的对照中的皮质活性。然后我们会 评估这种赞助商样活动的强度如何影响局部神经振荡和实时认知 表现。基于广泛的初步数据,我们假设赞助活动将随着 两组的年龄,这种增加的斜率将是艾滋病毒感染的成年人相对于对照组的钢人 并进一步强调了那些手。重要的是,我们还假设这些增加将是 与认知基础神经振荡强度的比例变化有关, 行为性能指数,例如准确性和反应时间。最后,在AIM 3中,我们将深入 根据根据源自的神经生理指标将样本分为组的学习方法 梅格(Meg),金标准是他们的整体神经心理学特征。

项目成果

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Tony W Wilson其他文献

Tony W Wilson的其他文献

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{{ truncateString('Tony W Wilson', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10346724
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Center for Pediatric Brain Health
儿科脑健康中心
  • 批准号:
    10798920
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10580768
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Alteration and Renovation
改建和翻新
  • 批准号:
    10346723
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Suppression of Pathological Spontaneous Cortical Dynamics and Inflammation in NeuroHIV
NeuroHIV 病理性自发皮质动力学和炎症的抑制
  • 批准号:
    10590619
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Neural Quantification & Imaging Core
神经量化
  • 批准号:
    10580773
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Center for Pediatric Brain Health
儿科脑健康中心
  • 批准号:
    10346722
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Center for Pediatric Brain Health
儿科脑健康中心
  • 批准号:
    10580767
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Neural Quantification & Imaging Core
神经量化
  • 批准号:
    10346725
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:
Suppression of Pathological Spontaneous Cortical Dynamics and Inflammation in NeuroHIV
NeuroHIV 病理性自发皮质动力学和炎症的抑制
  • 批准号:
    10472343
  • 财政年份:
    2022
  • 资助金额:
    $ 51.86万
  • 项目类别:

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  • 财政年份:
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  • 项目类别:
THE PROGRESSIVE ELEVATION OF SPONTANEOUS CORTICAL ACTIVITY IN HAND (PESCAH) PROJECT
手部自发皮质活动逐步提升 (PESCAH) 项目
  • 批准号:
    10370400
  • 财政年份:
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  • 资助金额:
    $ 51.86万
  • 项目类别:
MULTIMODAL IMAGING OF NEUROHIV DYNAMICS (MIND): AN OMAHA-PITTSBURGH CONSORTIUM
神经艾滋病毒动力学(心智)的多模态成像:奥马哈-匹兹堡联盟
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Medicaid data as a complement to cohort studies for investigating cancers among older people with HIV
医疗补助数据作为队列研究的补充,用于调查老年艾滋病毒感染者的癌症
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  • 资助金额:
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