Neural Quantification & Imaging Core

神经量化

• 批准号: 10346725
• 负责人: Tony W Wilson
• 金额: $ 50.84万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346725
• 关键词: Adult; Biological; Brain; Capital; Centers of Research Excellence; Child; Childhood; Collection; Communities; Community Health; Computer software; Core Facility; Data; Data Analyses; Data Analytics; Depreciation; Devices; Diffusion; Educational workshop; Engineering; Ensure; Environment; Equipment; Experimental Designs; Extramural Activities; Faculty; Fees; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Growth; Head; High Performance Computing; Home; Hospitals; Human; Image; Infant; Infrastructure; Institutes; Institution; International; Internships; Laboratories; Loudness; Magnetic Resonance Imaging; Magnetoencephalography; Magnetometries; Measurement; Measures; Mentors; Methods; Mission; Modality; Modernization; Neurosciences; Neurosciences Research; Optics; Participant; Performance; Perfusion; Pilot Projects; Play; Population; Positioning Attribute; Postdoctoral Fellow; Protocols documentation; Publications; Publishing; Pump; Research; Research Infrastructure; Research Project Grants; Research Support; Resolution; Resources; Role; Scientist; Site; Spectrum Analysis; Stretching; Structure; System; Technical Expertise; Techniques; Training; Training Programs; Work; advanced system; analytical method; base; boys; brain health; brain research; computerized data processing; connectome; data acquisition; experience; experimental study; improved; instrument; instrumentation; laboratory experience; mid-career faculty; multimodal neuroimaging; multimodality; neuroimaging; neurophysiology; neuroregulation; new technology; novel; post-doctoral training; prisma; programs; relating to nervous system; research and development; spectroscopic imaging; square foot; success; tool

Abstract/Summary: Neural Quantification & Imaging Core The Neural Quantification & Imaging Core will manage, support, and provide access to the major equipment and resources of the Center for Pediatric Brain Health. It will be the only research core of the Center and will be housed in the new 15,000+ square feet Institute for Human Neuroscience at Boys Town National Research Hospital (BTNRH). The Core will provide critical support and infrastructure to all four of the COBRE research project leaders (RPLs), as well as a collection of established research programs associated with the Institute and across BTNRH more broadly. The key equipment and resources of the Core will include two state-of-the- art Triux Neo magnetoencephalography (MEG) systems for recording and imaging neural oscillations, a 3-Tesla Siemens Prisma MRI scanner equipped with high-performance gradients and a 64-channel head coil for high- resolution structural, functional, diffusion, and spectroscopic imaging, and a realistic mock scanner for helping children and other participants prepare for the claustrophobic and loud MRI environment. In addition, the Core will operationalize a brain stimulation suite, extensive computing and data processing resources, comprehensive analytical support, and in the near future, an ultra-modern optically-pumped magnetometry (OPM) system for advanced neurophysiological measurements. The Neural Quantification & Imaging Core will also host at least two neuroimaging workshops per year, support targeted equipment usage through the Center’s pilot projects program, and serve as the home base for fellows supported through the Center’s postdoctoral neuroimaging training program. The Core will be directed by Dr. Tony Wilson, who is an expert in multimodal neuroimaging with over 20 years of experience with MEG imaging, structural and functional MRI, brain stimulation, and other tools and analytical approaches for advanced human neuroscience research. The Core’s staff will also include a dedicated site engineer/physicist and technicians for the MEG and MRI systems. Financially, the Core will be supported by instrument use fees, BTNRH, and the COBRE, with BTNRH covering any year-to-year deficits and all capital depreciation. As the only Core at BTNRH capable of measuring biological parameters of the living human brain, the facility will fill a major void in the institution’s overall research infrastructure and be a critical component to the success of the Center for Pediatric Brain Health.

摘要/摘要：神经定量和成像核心 神经量化和成像核心将管理，支持并提供对主要设备的访问 小儿大脑健康中心的资源。它将是该中心的唯一研究核心 被安置在新的15,000平方英尺的人类神经科学研究所中 医院（BTNRH）。核心将为所有四个毛病研究提供关键的支持和基础设施 项目负责人（RPL）以及与研究所相关的既定研究计划的集合 以及跨BTNRH更广泛。核心的关键设备和资源将包括两个最先进的 用于记录和成像神经振荡的ART TRIUX NEO磁脑摄影（MEG）系统，3 tesla 西门子Prisma MRI扫描仪配备了高性能梯度和64通道头线线圈 分辨率结构，功能，扩散和光谱成像，以及可帮助的现实模拟扫描仪 儿童和其他参与者为幽闭恐惧症和大声的MRI环境做准备。另外，核心 将操作大脑刺激套件，广泛的计算和数据处理资源，全面 分析支持，以及在不久的将来，一种超现代的光泵磁力测定法（OPM）系统 晚期神经生理测量。神经定量和成像核心至少也将托管 每年两次神经影像学研讨会，通过该中心的试点项目支持针对目标的设备使用 计划，并充当该中心博士后神经影像学支持者的家乡 培训计划。核心将由托尼·威尔逊（Tony Wilson）博士执导，他是多模式神经影像专家 拥有超过20年的MEG成像，结构和功能性MRI，大脑刺激和其他经验 高级人类神经科学研究的工具和分析方法。核心的员工还将包括 MEG和MRI系统的专用现场工程师/物理学家和技术人员。在财务上，核心将是 在仪器使用费的支持下，btnrh和cobre，btnrh涵盖了任何逐年定义 以及所有资本折旧。作为BTNRH的唯一核心，能够测量生命的生物学参数 人脑，该设施将填补该机构整体研究基础设施的主要空隙，并且是关键 小儿大脑健康中心成功的组成部分。