Center for Pediatric Brain Health

儿科脑健康中心

• 批准号: 10798920
• 负责人: Tony W Wilson
• 金额: $ 25万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798920
• 关键词: 3D Print; Acceleration; Administrative Supplement; Adolescent; Adult; Area; BRAIN initiative; Brain; Brain imaging; Centers of Research Excellence; Child; Childhood; Clip; Code; Cognitive; Communication; Coupling; Custom; Dedications; Development; Elements; Environment; Evolution; Extramural Activities; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Head; Helium; Hospitals; Human; Image; Immune; Infant; Infrastructure; Institution; International; Life; Liquid substance; Magnetic Resonance Imaging; Magnetism; Magnetoencephalography; Magnetometries; Maps; Measurement; Measures; Mentors; Methods; Modality; Motion; Movement; National Institute of General Medical Sciences; Nebraska; Neurologic; Neurons; Neurosciences; Noise; North America; Optics; Parents; Participant; Physics; Population; Predisposition; Productivity; Publishing; Pump; Research; Research Personnel; Research Project Grants; Scalp structure; Science; Scientist; Sensory; Shapes; Signal Transduction; Site; Social Interaction; Source; System; Techniques; Temperature; Time; Translating; Work; boys; brain health; cohort; data acquisition; density; design; high resolution imaging; imaging facilities; imaging modality; improved; innovation; insight; instrumentation; magnetic field; millimeter; millisecond; neonate; neural; neuroimaging; neurophysiology; programs; quantum; sensor; square foot; temporal measurement

Abstract/Summary: Administrative Supplement for the Center for Pediatric Brain Health The Center for Pediatric Brain Health is a NIGMS COBRE at Boys Town National Research Hospital (BTNRH) that recently entered its second year. The Center is housed in the new, state-of-the-art, 15,000+ square foot Institute for Human Neuroscience building on the main Boys Town campus. The key components of the Center include the Administrative Core, one research core (i.e., the Neural Quantification and Imaging Core), four research project leaders (RPLs), a Supervisory and Mentoring Committee, and a cohort of established pediatric neuroscientists. The Center has unique strengths in the area of dynamic neuroimaging, with one of the largest and most productive magnetoencephalography (MEG) groups in the world. MEG is a noninvasive neuroimaging method with millimeter spatial precision and millisecond temporal resolution that is ideal for studying children due to its open, non-claustrophobic design and completely silent data acquisition environment. However, like MRI and other human neuroimaging modalities, the method is susceptible to participant movement, which has typically limited its application to children who are typically about six years or older. In 2022, the Center for Pediatric Brain Health installed the first high-density optically-pumped magnetometry (OPM) unit in North America. OPM is a new method that measures the same magnetic fields detected in MEG but does so by harnessing recent breakthroughs in quantum physics that were rapidly accelerated by President Obama’s BRAIN Initiative. These key breakthroughs allow the sensors to operate at room temperature and be placed directly on the scalp, which means the measured magnetic fields are much stronger than in MEG (i.e., improved signal-to-noise ratio) and the sensors move with the head. The latter quality means that OPM is much more tolerant of head motion than MEG, MRI, and other comparable imaging modalities and thus enables high resolution imaging in very young children. Our current OPM array contains 128-channels and is optimized for older adolescents and adults and has been used extensively despite the short time since installation. During this time, we have also made custom arrays for babies as young as three-months-old by attaching the OPM sensors to baby hats (e.g., beanie caps) using custom 3D-printed clips. While such innovation has helped move us forward, a dedicated array for neonates, infants, and other very young children would revolutionize this work and lead to high precision dynamic functional maps of neural activity from babies at the earliest stages of life. Further, such a second array would allow “hyper-scanning” of parent-child dyads and illuminate how some of the most important social interactions in life shape the trajectory of brain development thereafter. Thus, through this administrative supplement and significant institutional funding, we are requesting support to acquire, install, and integrate a 64-channel OPM array for advancing pediatric neuroscience. When complete, this OPM system will be the first of its kind in the world and advance multiple research programs associated with our Center, while also establishing the Center as an international hub for developmental neuroscience.

摘要/摘要：小儿大脑健康中心的行政补充 小儿大脑健康中心是男孩镇国家研究医院（BTNRH）的纽布斯毛病 最近进入第二年。该中心位于新的，最先进的15,000平方英尺 主要男孩镇校园的人类神经科学大楼研究所。中心的关键组成部分 包括行政核心，一个研究核心（即神经定量和成像核心），四个 研究项目负责人（RPLS），一个监督和指导委员会，以及一群已建立的儿科 神经科学家。该中心在动态神经影像领域具有独特的优势，其中最大之一 以及世界上大多数生产力的磁脑摄影（MEG）组。 MEG是无创神经影像 毫米空间精度和毫米临时分辨率的方法，非常适合研究儿童 由于其开放，非乳脂恐惧症设计和完全无声的数据采集环境。但是，喜欢 MRI和其他人类神经影像学方式，该方法容易受到参与运动的影响， 通常将其应用限制在通常大约六岁或以上的儿童中。 在2022年，小儿脑健康中心安装了第一个高密度光泵的磁力测定法 （OPM）北美的单位。 OPM是一种测量MEG中检测到相同磁场的新方法 但是这样做是通过利用总统迅速加速的量子物理学的最新突破 奥巴马的大脑倡议。这些关键突破使传感器可以在室温下运行，并且 直接放在头皮上，这意味着测得的磁场比MEG强得多（即 提高的信噪比），传感器随头部移动。后一种质量意味着OPM很多 比MEG，MRI和其他可比较的成像方式更宽容头部运动，因此可以高 分辨率成像很小的孩子。我们当前的OPM阵列包含128通道，并针对 年长的青少年和成年人，并且已广泛要求自安装以来短暂的时间。期间 这次，我们还通过附加OPM制作了三个月大的婴儿的定制阵列 使用自定义的3D打印夹的婴儿帽的传感器（例如，无檐小便帽盖）。虽然这种创新有所帮助 向我们前进，新生儿，婴儿和其他非常年幼的孩子会革新 这项工作并导致最早的婴儿神经元活动的高精度动态功能图 生活阶段。此外，这样的第二个阵列将允许“超级扫描”亲子二元组并照明 生活中一些最重要的社会互动如何塑造此后大脑发育的轨迹。 通过这种行政补充和大量的机构资金，我们要求支持 获取，安装和集成一个64通道OPM阵列，用于推进儿科神经科学。完成后， 该OPM系统将是世界上第一个同类系统，并推进了相关的多个研究计划 借助我们的中心，同时还将该中心作为国际发育神经科学枢纽。

项目成果

Auditory experience modulates fronto-parietal theta activity serving fluid intelligence.

• DOI: 10.1093/braincomms/fcac093
• 发表时间: 2022
• 期刊: Brain communications
• 影响因子: 4.8

The development of sensorimotor cortical oscillations is mediated by pubertal testosterone.

• DOI: 10.1016/j.neuroimage.2022.119745
• 发表时间: 2022-12-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Fung, Madison H.;Heinrichs-Graham, Elizabeth;Taylor, Brittany K.;Frenzel, Michaela R.;Eastman, Jacob A.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.

Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth.

• DOI: 10.1016/j.dcn.2023.101257
• 发表时间: 2023-06
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Killanin, Abraham D.;Taylor, Brittany K.;Embury, Christine M.;Picci, Giorgia;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Heinrichs-Graham, Elizabeth;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.

Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers.

• DOI: 10.1192/j.eurpsy.2022.2325
• 发表时间: 2022-10-13
• 期刊: EUROPEAN PSYCHIATRY
• 影响因子: 7.8
• 作者: Kerr-German, Anastasia;White, Stuart F.;Santosa, Hendrik;Buss, Aaron T.;Doucet, Gaelle E.
• 通讯作者: Doucet, Gaelle E.

Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth.

• DOI: 10.1016/j.ynstr.2023.100599
• 发表时间: 2024-03
• 期刊: NEUROBIOLOGY OF STRESS
• 影响因子: 5
• 作者: Schantell, Mikki;Mansouri, Amirsalar;Arif, Yasra;Rice, Danielle L.;Wang, Yu-Ping;Calhoun, Vince D.;Stephen, Julia M.;Wilson, Tony W.
• 通讯作者: Wilson, Tony W.