Training Program in Molecular Medicine

分子医学培训计划

• 批准号: 10425392
• 负责人: George Lister
• 金额: $ 20.81万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10425392
• 关键词: Molecular Medicine; Training Programs

PROJECT SUMMARY In 2006 Yale started the innovative Medical Research Scholars Program (MRSP) with the mission of providing broad and deep Ph.D. training in the core basic science concepts of molecular biology, cell biology, biochemistry, genetics, physiology, pharmacology, and pathology, integrated with intensive exposure to medically oriented coursework and mentored clinical experiences designed specifically for Ph.D. students. The ultimate goal of this training is to prepare our students to be future interdisciplinary leaders in the biomedical sciences, with a unique ability to pursue clinically relevant fundamental basic science inquiry aimed at elucidating the molecular mechanisms of disease. Until the award of the first five years of NIGMS T32 support that we are now seeking to renew, MRSP had been supported by a combination of institutional funds and funds provided by the Howard Hughes Medical Institute (HHMI). Termination of HHMI support after the 2013-2014 academic year, and the desire to continue this highly successful ongoing program constituted the rationale for applying for the first five-year award of this Molecular Medicine (MM) Training Grant, which supported four trainee slots per year. Yale University supports all first-year PhD students in the biomedical sciences, and thus this T32 supports two second-year and two thrid-year students each year. MRSP students participate in a variety of program activities designed to engage Ph.D. students in medically relevant training and experiences throughout their graduate studies. The classes focus first on normal human physiology, organ-based cell biology, and biostatistics, followed by human pathobiology and an introduction to drug discovery, validation, and clinical trials. MRSP students also have the option to participate with first-year Yale MD students in weekly small-group physiology “case conference” tutorials, in which they explore in depth the physiological underpinnings of particular disease states. The cornerstone of the MRSP is a two-year mentored clinical experience that provides students with in-depth exposure to the science behind human diseases and first-hand longitudinal encounters with patients to contextualize the mechanistic basis of disease in a way that is not possible through traditional classroom learning. In addition to these formal activities, the MRSP also provides ongoing mentoring to all MRSP trainees regarding selection of a thesis research laboratory and assembly of the dissertation committee to support the goal of the NIGMS Molecular Medicine program to provide training in the basic biomedical sciences with a focus on elucidating the mechanisms of human disease. Based on the great demand for admission into the MRSP by outstanding training-grant-eligible students already admitted to Yale's umbrella biomedical sciences PhD program, we are requesting an increase in the number of annual slots from four to six, which would allow us to support three second-year and three third-year students each year.

项目摘要 2006年，耶鲁大学启动了创新的医学研究学者计划（MRSP）的任务 提供广泛而深入的博士学位核心基础科学培训分子生物学，细胞生物学， 生物化学，遗传学，生理学，药理学和病理学，并集成 以医学为导向的课程和专门为博士设计的临床经验。学生。这 这项培训的最终目标是使我们的学生成为生物医学的未来跨学科领导者 科学，具有独特的临床相关基础科学探究的独特能力 阐明疾病的分子机制。直到NIGMS T32支持的头五年授予 我们现在正在寻求续订，MRSP得到了机构资金和资金的组合的支持 由霍华德·休斯医学院（HHMI）提供。 2013-2014之后的HHMI支持终止 学年，以及继续这项非常成功的持续计划的愿望构成了 申请该分子医学（MM）培训补助金的第一个五年奖 每年实习生老虎机。耶鲁大学为生物医学科学的所有一年级博士学位学生提供支持，因此 该T32每年为两年和两年的学生提供支持。 MRSP学生参加 旨在参与博士学位的各种计划活动接受医学相关培训和经验的学生 通过他们的研究生学习。这些课程首先关注正常的人类生理学，组织基于细胞 生物学和生物统计学，其次是人类病理学以及药物发现，验证概论， 和临床试验。 MRSP学生还可以选择与耶鲁大学一年级MD学生一起参加 每周的小组生理学“病例会议”教程，他们深入探索生理学 特定疾病状态的基础。 MRSP的基石是两年的指导临床 经验为学生提供了深入的人类疾病背后科学的接触 与患者的纵向遭遇，以不属于疾病的机理基础 通过传统的课堂学习可能。除了这些正式活动，MRSP还提供 对所有MRSP受训者的持续心态，以选择论文研究实验室和组装 论文委员会支持NIGMS分子医学计划的目标，以提供培训 基本的生物医学科学侧重于阐明人类疾病的机制。基于伟大 杰出的培训授予资格的学生对入学的需求已经接受 耶鲁大学的伞生物医学科学博士计划，我们要求增加年度插槽数量 从四到六个，这将使我们每年支持三年级和三名三年级学生。

项目成果

Efficient quantitative monitoring of translational initiation by RelE cleavage.

• DOI: 10.1093/nar/gkac614
• 发表时间: 2022-10-14
• 期刊: NUCLEIC ACIDS RESEARCH
• 影响因子: 14.9
• 作者: Focht, Caroline M.;Strobel, Scott A.
• 通讯作者: Strobel, Scott A.

A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope.

• DOI: 10.1083/jcb.202304026
• 发表时间: 2023-09-04
• 期刊: The Journal of cell biology

Temperature sensitivity of two-pore (K2P) potassium channels.

• DOI: 10.1016/b978-0-12-800181-3.00005-1
• 发表时间: 2014
• 期刊: Current topics in membranes
• 作者: Schneider ER;Anderson EO;Gracheva EO;Bagriantsev SN
• 通讯作者: Bagriantsev SN

Species-specific temperature sensitivity of TRPA1.

• DOI: 10.1080/23328940.2014.1000702
• 发表时间: 2015-04
• 期刊: Temperature (Austin, Tex.)
• 作者: Laursen WJ;Anderson EO;Hoffstaetter LJ;Bagriantsev SN;Gracheva EO
• 通讯作者: Gracheva EO

Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans.

• DOI: 10.1016/j.jaci.2017.03.026
• 发表时间: 2017-10
• 期刊: The Journal of allergy and clinical immunology
• 作者: Takeda AJ;Zhang Y;Dornan GL;Siempelkamp BD;Jenkins ML;Matthews HF;McElwee JJ;Bi W;Seeborg FO;Su HC;Burke JE;Lucas CL
• 通讯作者: Lucas CL