Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC)

内华达州探索性阿尔茨海默病研究中心 (NVEADRC)

• 批准号: 10220839
• 负责人: Justin Benjamin Miller
• 金额: $ 108.41万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220839
• 关键词: Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Awareness; Catchment Area; Characteristics; Clinic; Clinical Data; Collaborations; Collection; Communities; Data; Data Collection; Data Set; Dementia; Development; Diagnosis; Disease; Elderly; Enrollment; Ensure; Faculty; Fostering; Funding; Future; General Population; Geography; Goals; Government; Health Personnel; Health care facility; Healthcare; Impaired cognition; Incidence; Individual; Infrastructure; Knowledge; Lead; Literature; Longitudinal Studies; Mentors; Methodology; Mission; National Institute on Aging; Neurologist; Nevada; Nongovernmental Organizations; Participant; Patients; Physicians; Population; Population Growth; Primary Care Physician; Research; Research Personnel; Resources; Risk; Risk Factors; Rural; Rural Community; Rural Population; Source; Specimen; Standardization; Study Subject; Technology; Training; Transportation; Underserved Population; United States National Institutes of Health; Universities; Urban Community; Urban Population; authority; base; brain health; cohort; demented; dementia care; dementia risk; experience; frontier; health care disparity; health care quality; health care service; health disparity; human old age (65+); improved; interest; metropolitan; nervous system disorder; novel; operation; outreach; programs; ranpirnase; recruit; repository; retiree; rural area; rural healthcare; rural patients; rural setting; rural underserved; skills; smartphone based assessment; success; tool; treatment optimization; urban area

NVEADRC OVERALL SUMMARY Health and healthcare disparities in rural vs. urban areas are recognized for several decades, and this is particularly true for Alzheimer’s disease (AD) and Alzheimer’s disease related dementia (ADRD). Primary care physicians (PCPs) are rarely equipped with the skills and tools to diagnose the specific type of dementia their geriatric patients may be suffering. Because of possible long distances between rural areas and the nearest metropolitan area possessing expert dementia neurologists, some patients may never be diagnosed with dementia or may be misdiagnosed with the incorrect form of dementia. Previous Alzheimer Disease Research Centers (ADRCs) have explored rural risks and disparities for AD, but only as satellite programs rather than a major focus of their activities. Moreover, the literature on demented patients in rural areas is scarce and usually include only a small number of individuals with limited sets of biomedical data to be able to compare to datasets from the National Alzheimer’s Coordinating Center (NACC). Such gaps in healthcare offering and lack of reliable data on rural subjects is motivating us to create the Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC). Our new Center is based on previous strong collaborations between the Las Vegas Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). In Aim 1, we will build the necessary infrastructure for the operations of our research enterprise. This includes the creation of novel methodologies and technologies to collect high-quality standardized clinical data in rural settings. In Aim 2, by utilizing the experience of our Outreach, Recruitment and Engagement Core we will foster our network of stakeholders, from government entities, to PCPs, down to rural patients themselves to make them feel that they own the NVEADRC project. In Aim 3, we will plan the transition from an exploratory stage to a full ADRC by demonstrating the feasibility of collecting longitudinal data from our rural cohort. By adding rural population information to the NACC set of data, our NVEADRC will provide novel resources that could be used by the broader AD/ADRD research community, which will significantly contribute to the overall mission of the ADRC network.

NVEADRC 整体 概括 几十年来人们一直认识到农村地区与城市地区的健康和医疗保健差异，这是 对于阿尔茨海默病 (AD) 和阿尔茨海默病相关痴呆 (ADRD) 来说尤其如此。 医生 (PCP) 很少具备诊断特定类型痴呆症的技能和工具。 由于农村地区与最近的地方之间可能存在较远的距离，因此老年患者可能会遭受痛苦。 大都市区拥有痴呆症神经科医生专家，有些患者可能永远不会被诊断出患有痴呆症 痴呆症或可能被错误诊断为痴呆症。 中心 (ADRC) 探索了农村 AD 风险和差异，但只是作为卫星项目而不是一个整体 此外，有关农村地区痴呆症患者的文献很少，而且通常很少。 仅包括少数具有有限生物医学数据集的个人，以便能够与数据集进行比较 国家阿尔茨海默病协调中心 (NACC) 指出医疗保健服务方面存在差距，而且缺乏可靠的服务。 有关农村受试者的数据激励我们创建内华达州探索性阿尔茨海默病研究中心 (NVEADRC) 我们的新中心基于之前与拉斯维加斯 Lou Ruvo 之间的密切合作。 脑健康中心 (LRBCH) 和内华达大学拉斯维加斯分校 (UNLV) 在目标 1 中，我们将建立 我们的研究企业运营所需的基础设施，其中包括新颖的创作。 在目标 2 中，收集高质量标准化临床数据的方法和技术。 利用我们的外展、招聘和参与核心的经验，我们将培育我们的网络 利益相关者，从政府实体到 PCP，再到农村患者本身，让他们感到自己 拥有 NVEADRC 项目 在目标 3 中，我们将计划通过以下方式从探索阶段过渡到完整的 ADRC。 证明通过添加农村人口从农村队列收集纵向数据的可行性。 信息到 NACC 数据集，我们的 NVEADRC 将提供可供更广泛的人使用的新颖资源 AD/ADRD 研究社区，将为 ADRC 网络的总体使命做出重大贡献。