NVEADRC Administrative Core (AC)

NVEADRC 行政核心 (AC)

基本信息

批准号：
10220840
负责人：
Justin Benjamin Miller
金额：
$ 32.92万
依托单位：
CLEVELAND CLINIC FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10220840
关键词：
Address Advisory Committees Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Automobile Driving Awareness Biological Markers Brain imaging Budgets Caring Charge Clinic Clinical Clinical Trials Collaborations Communication Communities Competence Data Data Analyses Data Security Dementia Education Educational Activities Elderly Ensure Event Faculty Feedback Female Fostering Future Goals Grant Health Personnel Healthcare Human Individual Infrastructure International Lead Leadership Medical Mission Modeling Monitor Neurodegenerative Disorders Neurosciences Nevada Pamphlets Participant Patient Care Patients Performance Pilot Projects Policies Population Preparation Procedures Productivity Research Research Activity Research Personnel Resources Running Rural Rural Community Safety Secure Site Specific qualifier value Specimen Suggestion Supervision Technology Telemedicine Training and Education United States National Institutes of Health Universities Work authority base brain health career development cohort data exchange data management education research experience health care disparity human subject improved learning materials meetings multidisciplinary neuropathology novel operation outreach programs ranpirnase recruit rural area rural disparities rural healthcare statistics teleneurology teleneuropsychology women faculty

项目摘要

NVEADRC ADMINISTRATIVE CORE (AC) SUMMARY Our Nevada Exploratory Alzheimer’s Disease Research Center (NVEADRC) is a novel and ambitious research endeavor aiming at filling a gap from existing ADRCs, which is to collect and share high-quality biomedical data and specimens from individuals suffering dementia from rural areas. Like for all novel enterprises, the NVEADRC needs a fully committed leadership to steer and prioritize its activities from the beginning of the project. For this, we have selected strong leaders with prior ADRC experience to lead the project. The Administrative Core (AC) is the driving entity for our NVEADRC. It will oversee the research and educational activities of a strong multidisciplinary team composed of investigators from the Cleveland Clinic Lou Ruvo Center for Brain Health (LRBCH) and University of Nevada, Las Vegas (UNLV). Most of the investigators are already part of other collaborative projects, which will greatly facilitate communication between the different Cores early on since most actors in the enterprise are already aware of the requirements for a successful large collaborative project. We have set four strategic aims for the AC. In Aim 1, the AC will set up Cores operations with the goal of running this project over several decades. For this, the AC will call monthly meetings with all Core leaders to address progress and challenges. The meeting minutes will be sent to all NVEADRC actors to collect feedback for improvement and suggestions on novel directions. The AC will assure the successful integration of participating rural sites and investigators, and promote collaborations within the ADRC network. The AC will coordinate the review and guidance of the NVEADRC by integrating the feedback from an internal and an external advisory committee. In Aim 2, the AC will work on professionalizing rural dementia healthcare and scientific research by determining the specific needs of rural medical professionals in neurodegenerative disorders education to create specific courses and materials (e.g. brochures and videos) for large broadcasting in NV and beyond. Moreover, by fostering the career development of female faculty the AC wants to offer a transformative experience to build a pipeline of future female ADRC collaborators and project leaders. In Aim 3, we will leverage our community connections to inform patients about clinical trials and to recruit rural subjects in our clinical cohort. In Aim 4, the AC will develop the necessary assessment procedures for compliance and to monitor performance. This includes compliance with human subjects, scientific integrity, information security and financial policy requirements from NIH. In addition, the AC will create the procedures for Core assessments to gauge progress based on pre- determined annual goals. Very importantly, the AC is in charge of the successful transfer of the data captured from our rural subjects to the National Alzheimer’s Coordinating Center (NACC). Under its strong leadership, our team is ready to tackle this human challenge in order to dramatically improve dementia research and healthcare in the State of Nevada.

NVEADRC 管理核心 (AC) 概括我们的内华达州探索性阿尔茨海默病研究中心 (NVEADRC) 是一项新颖且雄心勃勃的研究努力填补现有 ADRC 的空白，即收集和共享高质量的生物医学数据和来自农村地区患有痴呆症的个体的标本，就像所有新颖的企业一样，NVEADRC。需要一个全力投入的领导层从项目一开始就指导其活动并确定其优先顺序。我们选择了具有 ADRC 经验的强有力的领导者来领导该项目。是我们 NVEADRC 的驱动实体，它将监督一个强大的研究和教育活动。由克利夫兰诊所 Lou Ruvo 脑健康中心的研究人员组成的多学科团队（LRBCH）和内华达大学拉斯维加斯分校（UNLV）的大多数研究人员已经是其他研究人员的一部分。协作项目，这将极大地促进不同核心之间的早期沟通，因为大多数企业中的参与者已经意识到成功的大型协作项目的要求。为 AC 设定四个战略目标在目标 1 中，AC 将建立核心业务，以实现这一目标。为此，审计委员会将每月与所有核心领导人召开会议，讨论进展情况。会议纪要将发送给所有 NVEADRC 参与者，以收集反馈以进行改进。并就新方向提出建议。AC 将确保参与的农村站点和项目的成功整合。调查人员，并促进 ADRC 网络内的合作。 AC 将协调审查和评估。通过整合内部和外部咨询委员会的反馈来提供 NVEADRC 的指导。目标 2，AC 将通过确定农村痴呆症医疗保健和科学研究的专业化农村医疗专业人员在神经退行性疾病教育方面的具体需求，以创建具体的内华达州及其他地区大型广播的课程和材料（例如小册子和视频）。为了促进女性教师的职业发展，AC 希望提供变革性的经验来建立在目标 3 中，我们将利用我们的社区来培养未来的 ADRC 女性合作者和项目领导者。在目标 4 中，向患者通报临床试验并招募农村受试者。 AC 将制定必要的合规评估程序并监控绩效。遵守人类受试者、科学诚信、信息安全和金融政策要求此外，美国国立卫生研究院 (NIH) 将制定核心评估程序，以根据预评估评估进展情况。非常重要的是，AC 负责成功传输所捕获的数据。从我们的农村受试者到国家阿尔茨海默病协调中心 (NACC)，在其强有力的领导下，我们的团队已准备好应对这一人类挑战，以显着改善痴呆症研究和医疗保健在内华达州。