Sex and Age Differences in Immunity to Influenza (SADII)

流感免疫力的性别和年龄差异 (SADII)

• 批准号: 10213168
• 负责人: SABRA L. KLEIN
• 金额: $ 163.7万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213168
• 关键词: Address; Adult; Adverse reactions; Affect; Age; Age-Years; Aging; Animal Model; Antiviral Agents; Autoimmune; Avian Influenza; Biological; Biological Aging; Cells; Centers of Research Excellence; Cessation of life; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Community Health; Complex; Data; Development; Disease; Disease Outcome; Female; Gender; Genes; Genetic; Health; Hormonal; Hospitalization; Human; Immune; Immune response; Immunity; Immunologics; Immunology; Infection; Inflammation; Inflammatory; Influenza; Influenza vaccination; Interdisciplinary Study; International; Journals; Leadership; Life Cycle Stages; Longevity; Mediating; Memory; Microbiology; Mission; Pathogenesis; Pathology; Pharmacotherapy; Physicians; Population; Positioning Attribute; Principal Investigator; Productivity; Public Health; Publishing; Recommendation; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Scientist; Sex Bias; Sex Differences; Social outcome; Societies; Specialized Center; Statistical Models; Testing; Time; Translational Research; United States; United States National Institutes of Health; Universities; Ursidae Family; Vaccination; Vaccine Antigen; Vaccines; Women' s Health; age difference; age related; biological sex; career; development policy; experience; frailty; human old age (65+); improved; infectious disease treatment; influenza infection; influenza outbreak; influenza virus vaccine; influenzavirus; male; novel; outcome prediction; pandemic influenza; pathogen; preclinical study; programs; response; seasonal influenza; sex; translational approach; translational research program; translational scientist; treatment response; trend; universal influenza vaccine; vaccination outcome; vaccine efficacy; vaccine-induced immunity; young adult

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) SUMMARY The NIH Office of Research on Women’s Health (ORWH) should support a Specialized Center of Research Excellence (SCORE) on sex differences in influenza immunity because despite having antivirals and vaccines, influenza remains a significant public health threat, causing approximately 100,000 hospitalizations, 30,000 deaths, and approximately $7 billion in lost productivity in the United States, alone. Sex and age are emerging as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) SCORE will leverage the internationally recognized research, resources, and educational opportunities at Johns Hopkins University to transform women’s health and impact the development of and policy decisions about influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis being tested through the SADII SCORE Research Projects is that female-biased vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal and genetic differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens. SADII will bring together investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using quantitative and qualitative statistical models. By using the combined expertise in our research groups, SADII is uniquely positioned to identify the biological basis behind sex and age differences in immune responses to influenza vaccination and disseminate those findings to the broader research, clinical, and public health communities. The overarching mission of the SADII SCORE will be achieved through the following Specific Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences in immunology and infectious diseases; 2) To systematically evaluate sex differences in vaccine-induced immune responses across the life course using translational approaches involving human studies and mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex, and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and immunology.

性别和年龄差异对流感的免疫力（SADII）摘要 NIH妇女健康研究办公室（ORWH）应支持专业的研究中心 卓越（得分）对影响萨免疫的性别差异，因为尽管有抗病毒药和阴道，但 流感仍然是一个重大的公共卫生威胁 仅在美国，死亡人数约为70亿美元。性别和年龄正在出现 作为两个宿主变量，显着影响了影响感染影响的发病机理 流感疫苗。性别和年龄差异对流感的免疫力（SADII，明显sādē）得分 将利用约翰斯的国际认可的研究，资源和教育机会 霍普金斯大学改变妇女的健康并影响有关的制定和政策决策 流感疫苗计划，包括普遍影响。测试的总体假设 通过SADII得分研究项目是女性偏见的疫苗诱导的对影响的免疫力 病毒依赖年龄，反映了影响性别的性别差异和遗传差异 免疫反应（即效应子和记忆）对影响Za疫苗抗原的影响。萨迪会汇聚在一起 研究人员的重点是1）现有年龄和性别分层的季节性影响 人口; 2）可以测试研究假设和作用机制的动物模型 在人口中； 3）年龄，脆弱，性别和性别对使用疫苗结果的贡献 定量和定性统计模型。通过使用我们的研究小组中的联合专业知识，Sadii 是独特的定位，可以确定性别和年龄差异背后的生物学基础 流感疫苗接种并将这些发现传播给更广泛的研究，临床和公共卫生 社区。 SADII分数的总体任务将通过以下特定来实现 目的：1）在与其他实体的SADII分数和协作中提供领导和监督 约翰·霍普金斯（Johns Hopkins）和其他地方开发了一项翻译研究计划，重点是性别和年龄差异 免疫学和传染病； 2）系统评估疫苗诱导的性别差异 使用涉及人类研究和 机械动物模型； 3）满足潜水员翻译科学家的职业增强需求 研究约翰·霍普金斯及以后的性别差异。我们准备改变妇女的健康，性别， 以及对约翰·霍普金斯（Johns Hopkins）以及微生物学领域的签名计划的性别研究 免疫学。