JH-EPICS Administrative Core

JH-EPICS 管理核心

• 批准号: 10221905
• 负责人: SABRA L. KLEIN
• 金额: $ 31.58万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221905
• 关键词: 2019-nCoV; Antibody Response; COVID-19; Collection; Communication; Communities; Data; Development; Ensure; Evaluation; Fostering; Funding; Goals; Immune response; Immunity; Information Dissemination; International; Leadership; Mentors; Molecular Target; Pathogenesis; Patients; Peripheral Blood Mononuclear Cell; Procedures; Professional Organizations; Progress Reports; Publications; Research; Research Personnel; Research Project Grants; Sampling; Serological; Site Visit; Specimen; T-Lymphocyte; United States National Institutes of Health; Universities; biobank; cellular targeting; data dissemination; data sharing; dissemination research; meetings; outreach; skills; social media; vaccine-induced immunity; web site

JH-EPICS ADMINISTRATIVE CORE SUMMARY The primary goal of the Johns Hopkins Excellence in Pathogenesis and Immunity Center for SARS-CoV-2 (JH- EPICS) is to systematically evaluate innate, T cell, and antibody responses to SARS-CoV-2 in peripheral blood mononuclear cells and serological samples from COVID-19 patients. Through in depth analyses, the JH- EPICS will identify the modifiers of the immune response and severe COVID-19 and isolate the cellular and molecular targets for COVID-19 treatments as well as the correlates of protection necessary for SARS-CoV-2 vaccine-induced immunity. The primary objective of the JH-EPICS Administrative Core (AC) is to provide centralized management, leadership, mentoring, sharing, and dissemination of the data from the proposed Research Projects and Cores in JH-EPICS to ensure that the overarching research goals can be met. The first Aim, under the Multiple PI leadership of Drs. Sabra Klein and Andrea Cox, will be to provide administrative and budgetary management as well as scientific leadership and communication for JH-EPICS. The JH-EPICS AC will distribute funds, organize monthly research meetings, and ensure integration of the JH-EPICS into the COVID-19 research and educational networks at Johns Hopkins University. The AC will also develop standard operating procedures for reviewing requests for specimens from the biorepository and their distribution as well as the collection, processing, and sharing of data generated by the JH-EPICS and approved by the SeroNet Steering Committee. The second Aim of the JH-EPICS AC will be to foster engagement with SeroNet and other network activities. The JH-EPICS AC will participate in all trans-SeroNet initiatives, including establishment of trans-SeroNet collaborative research projects. Finally, the third Aim of the JH-EPICS AC will be to enhance dissemination of research findings from the JH-EPICS and establish an evaluation plan. Dissemination of research findings from the JH-EPICS will involve publications and dissemination of results at the annual SeroNet meeting, national and international meetings of professional societies, and the monthly Center-wise research meetings. Development of a JH-EPICS website and social media presence will further assist with dissemination of research findings to a broader audience. Finally, the JH-EPICS AC will establish a rigorous evaluation plan, including annual progress reports, site visits, and requested documents (e.g., SOPs) from NIH. The goal will be to ensure appropriate management and productive dissemination of research and data from JH-EPICS to the broader community, including through public outreach.

JH-EPICS行政核心摘要 约翰·霍普金斯（Johns Hopkins）在SARS-COV-2的发病机理和免疫中心卓越的主要目标 EPICS）是系统地评估外周血中对SARS-COV-2的先天，T细胞和抗体反应 来自COVID-19患者的单核细胞和血清学样本。通过深入分析，JH- 史诗将识别免疫反应和严重的共同反应的修饰符，并分离细胞和分离 199治疗的分子靶标以及SARS-COV-2所需的保护相关性 疫苗诱导的免疫力。 JH-EPICS行政核心（AC）的主要目标是提供 集中管理，领导，指导，共享和传播拟议的数据 研究项目和JH-EPIC中的核心，以确保可以实现总体研究目标。第一个 目的，在Drs的多重PI领导下。 Sabra Klein和Andrea Cox将提供行政和 预算管理以及JH-EPIC的科学领导力和沟通。 JH-EPICS AC 将分配资金，组织每月的研究会议，并确保将JH-Epics整合到 约翰·霍普金斯大学的COVID-19-COVID-19研究和教育网络。 AC还将制定标准 审查生物座标本请求及其分布的操作程序 作为JH-EPICS生成并由Seronet批准的数据收集，处理和共享 指导委员会。 JH-EPICS AC的第二个目标是促进与Seronet和 其他网络活动。 JH-EPICS AC将参加所有跨性别倡议，包括 建立Trans-Seronet协作研究项目。最后，JH-EPICS AC的第三个目标将 要增强JH-EPIC的研究结果的传播并制定评估计划。 从JH-EPIC中传播研究结果将涉及出版和传播结果 年度Seronet会议，专业社会的国家和国际会议以及每月 中心研究会议。开发JH-EPICS网站和社交媒体的影响力将进一步 协助向更广泛的受众传播研究结果。最后，JH-EPICS AC将建立一个 严格的评估计划，包括年度进度报告，现场访问和要求的文件（例如SOP） 来自NIH。目的是确保适当的管理和生产性研究以及 从JH-EPIC到更广泛的社区的数据，包括通过公共宣传。