Sex and Age Differences in Immunity to Influenza (SADII)

流感免疫力的性别和年龄差异 (SADII)

• 批准号: 10261763
• 负责人: SABRA L. KLEIN
• 金额: $ 3.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261763
• 关键词: Affect; Age; Aging; Animal Model; Antiviral Agents; Award; Centers of Research Excellence; Cessation of life; Clinical; Collaborations; Communicable Diseases; Community Health; Female; Funding; Gender; Genetic; Hormonal; Hospitalization; Human; Immune response; Immunity; Immunology; Influenza; Influenza vaccination; International; Leadership; Life Cycle Stages; Memory; Microbiology; Mission; Parents; Pathogenesis; Policies; Population; Positioning Attribute; Productivity; Public Health; Qualitative Research; Research; Research Personnel; Research Project Grants; Resources; Role; Scientist; Sex Differences; Specialized Center; Statistical Models; Testing; Translational Research; United States; Universities; Vaccine Antigen; Vaccines; Women' s Health; age difference; age related; biological sex; career; development policy; frailty; gender difference; influenza infection; influenza virus vaccine; influenzavirus; novel; programs; response; seasonal influenza; sex; social; translational approach; translational research program; translational scientist; universal influenza vaccine; vaccination outcome; vaccine-induced immunity

Summary of funded parent award: Sex and Age Differences in Immunity to Influenza Despite the availability of antivirals and vaccines, influenza remains a significant public health threat; causing approximately 100,000 hospitalizations, 30,000 deaths, and approximately $7 billion in lost productivity per year in the United States alone. Sex and age are emerging as two host variables that significantly impact the pathogenesis of influenza virus infection and responses to influenza vaccines. The Sex and Age Differences in Immunity to Influenza (SADII, pronounced sādē) Specialized Center of Research Excellence (SCORE) leverages the internationally recognized research, resources, and educational opportunities at Johns Hopkins University to transform women’s health and impact policy decisions about influenza vaccine programs, including universal influenza vaccines. The overarching hypothesis of the SADII SCORE Research Projects is that female-biased, vaccine-induced immunity to influenza viruses is age-dependent and reflects both hormonal, genetic, and social differences between the sexes that impact immune responses (i.e., both effector and memory) to influenza vaccine antigens and outcomes. SADII brings together investigators focused on 1) seasonal influenza vaccination in an existing age and sex stratified human population; 2) animal models that can test hypotheses and mechanisms of action that are inferred from studies in human populations; and 3) the contributions of age, frailty, sex, and gender to vaccine outcomes using statistical models and qualitative research. By using the combined expertise in our research groups, SADII is uniquely positioned to identify the basis behind sex, age, and gender differences in immune responses to influenza vaccination and disseminate those findings to the broader research, clinical, and public health communities. The overarching mission of the SADII SCORE will be achieved through the following Specific Aims: 1) To provide leadership and oversight of the SADII SCORE and collaboration with other entities at Johns Hopkins and elsewhere to develop a translational research program focused on sex and age differences in immunology and infectious diseases; 2) To systematically evaluate sex and gender differences in vaccine-induced immune responses across the life course using translational approaches involving human studies and mechanistic animal models; and 3) To meet the career enhancement needs of diverse translational scientists studying sex differences at Johns Hopkins and beyond. We are prepared to transform women’s health, sex, and gender research into a signature initiative at Johns Hopkins and in the fields of microbiology and immunology.

资助父母奖的摘要：对流感的免疫的性别和年龄差异 尽管有抗病毒药和疫苗的可用性，但影响力仍然是一个重大的公共卫生威胁。引起 每人约有100,000次住院，30,000人死亡和约70亿美元的生产力损失 仅在美国。性别和年龄正在成为两个主机变量，显着影响 影响病毒感染的发病机理和影响疫苗的反应。性别和年龄差异 对流感的免疫力（SADII，发音为Sādē）专业研究中心（得分） 利用约翰·霍普金斯（Johns Hopkins）的国际认可的研究，资源和教育机会 改变妇女的健康和影响有关影响力疫苗计划的政策决策的大学， 包括普遍影响。 SADII分数研究项目的总体假设是 雌性偏见，疫苗诱导的对影响病毒的免疫力是年龄依赖的，并且反映了两者 影响免疫反应的性别之间的荷尔蒙，遗传和社会差异（即两个效应器 和记忆）以影响扎疫苗抗原和结果。萨迪（Sadii）将重点关注的调查人员汇集在一起​​1） 现有年龄和性别分层人口的季节性影响者疫苗接种； 2）动物模型 可以测试人群研究中推断出的假设和作用机制； 3） 使用统计模型和定性的年龄，脆弱，性别和性别对疫苗结果的贡献 研究。通过在我们的研究小组中使用联合专业知识，Sadii可以独特地确定 性别，年龄和性别差异背后的基础，在对影响力疫苗接种的免疫反应中 这些发现对更广泛的研究，临床和公共卫生社区。总体任务的任务 SADII分数将通过以下特定目的实现：1）提供领导和监督 与约翰·霍普金斯（Johns Hopkins）和其他地方的其他实体的SADII分数和合作，以开发 转化研究计划的重点是免疫学和传染病的性别和年龄差异； 2） 系统地评估疫苗诱导的免疫反应中的性别和性别差异 采用涉及人类研究和机械动物模型的翻译方法；和3）到 满足潜水员翻译科学家的职业增强需求，研究约翰斯的性别差异 霍普金斯及以后。我们准备将妇女的健康，性和性别研究转变为签名 约翰·霍普金斯（Johns Hopkins）以及微生物学和免疫学领域的倡议。