Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10388185
• 负责人: Manish Arora
• 金额: $ 31.87万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388185
• 关键词: Address; Air Pollution; Applications Grants; Biological; Biological Assay; Biological Markers; Chemicals; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Collection; Communities; Complex; Consultations; Core Facility; Counseling; Data; Development; Discipline; Disease; Dose; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Pollutants; Epigenetic Process; Exposure to; Faculty; Faculty Recruitment; Financial Support; Fostering; Funding; Future; Genetic; Goals; Grant; Growth; Health; Health Sciences; Heart; Institutes; K-Series Research Career Programs; Laboratories; Life Cycle Stages; Link; Longitudinal cohort study; Measurement; Measures; Metal exposure; Methods; Mission; Modeling; Online Systems; Pilot Projects; Plant Roots; Play; Population; Procedures; Protocols documentation; Publications; Reporting; Reproducibility; Research; Research Personnel; Resources; Role; Science; Scientist; Services; Social Environment; Stress; Structure; Technology; Tooth structure; Toxic effect; Toxicology; Translating; United States National Institutes of Health; base; biological specimen archives; chemical property; cohort; design; disability; health science research; human population study; innovation; insight; member; metabolomics; molecular marker; new technology; novel; nutrition; pollutant; precision medicine; quality assurance; ranpirnase; remote sensing; response; response biomarker; sex; standard measure; study population; success; trend

Project Summary Mount Sinai's Transdisciplinary Center on Early Environmental Exposures was established in 2014 with the mission to promote transdisciplinary environmental health research across the life course. The Integrated Health Sciences Facility Core fulfills several critical components of our this mission by providing access to measures of environmental exposure, molecular biomarkers of effect and even human study populations that can be leveraged by Center Members in their Environmental health research. The IHSFC will continue to foster studies of environmental health sciences that embrace emerging concepts and technologies, such as mixtures, the “exposome” and satellite-based remote sensing of air pollution (a new service this grant cycle). The IHSFC encourages research that moves beyond reductionist studies assessing chemical toxicity in isolation to consider the totality of the environment, the context of exposure (nutrition/social environment or sex) and the complex interactions among these factors that ultimately predict our health. In keeping with the Center's mission to study transdisciplinary environmental health, the IHSFC serves as a gateway to a variety of expertise and resources under a single administrative umbrella. This structure provides an intellectual milieu that promotes collaboration, as the IHSFC is the transdisciplinary “heart” of the Center and functions as a central hub through which Center Members have access to multiple venues of service, from consultation on toxicologic properties of chemicals, to consultation on collection and measurement of standard and novel exposure biomarkers, to measurement of molecular biomarkers of effect, and to accessing existing cohorts and clinical populations. Our mission is to help investigators establish teams of collaborators who, together, will extend the boundaries of environmental health sciences. To achieve this, the IHSFC also develops cutting edge environmental measurements and biological response assays for Center Members, such as our highly successful tooth based biomarker of metal exposure that reconstructs past exposure dose and exposure timing. This biomarker played a key role in our recent NIH grant success being featured in 2 successful R01s, a K award and 2 ECHO cohort grants. In the coming grant cycle, we will continue to develop additional innovative methods to comprehensively measure exposure to environment insults, facilitate access to research populations and biospecimen archives, and guide researchers to existing core services across Mount Sinai. The IHSFC does not replicate services provided by other Mount Sinai core labs. Rather, we leverage and supplement other cores, such as our Clinical Translational Science Award (CTSA) funded cores, and facilitate access to CTSA core lab assays. Overall, the IHSFC of the Mount P30 Core Center at Mount Sinai is a critical resource that allows researchers to build highly efficient and collaborative teams that can address the role of environment on health across the life course.

项目概要 西奈山早期环境暴露跨学科中心成立于 2014 年， 其使命是促进整个生命过程中的跨学科环境健康研究。 健康科学设施核心通过提供访问权限来实现我们这一使命的几个关键组成部分 环境暴露量、效应生物标志分子甚至人类研究人群的测量 中心成员可以在其环境健康研究中加以利用 IHSFC 将继续促进。 环境健康科学研究涉及新兴概念和技术，例如混合物， 空气污染的“暴露组”和基于卫星的遥感（本资助周期的一项新服务）。 鼓励超越还原论研究的研究，单独评估化学毒性 考虑环境的整体性、暴露的背景（营养/社会环境或性）以及 这些因素之间复杂的相互作用最终预测了我们的健康状况，这与该中心的预测一致。 IHSFC 的使命是研究跨学科环境健康，它是通向各种领域的门户。 这种结构提供了一个知识环境。 促进合作，因为 IHSFC 是该中心的跨学科“心脏”，并充当 中心枢纽，中心会员可以通过该中心枢纽访问多个服务场所，从咨询 化学品的毒理学特性、标准品和新产品的收集和测量咨询 暴露生物标志物，测量效果的分子生物标志物，以及访问现有队列 我们的使命是帮助研究人员建立合作者团队，他们将共同努力。 扩展环境健康科学的界限 为了实现这一目标，IHSFC 还开发了切割技术。 为中心成员提供边缘环境测量和生物反应测定，例如我们的高度 成功的基于牙齿的金属暴露生物标志物，可重建过去的暴露剂量和暴露情况 这个生物标志物在我们最近 NIH 拨款成功中发挥了关键作用，并在 2 个成功的 R01 中得到了体现， 一项 K 奖和 2 项 ECHO 队列资助 在下一个资助周期中，我们将继续开发更多资金。 全面测量环境损害暴露程度的创新方法，促进研究的获取 人口和生物样本档案，并指导研究人员使用西奈山现有的核心服务。 IHSFC 不会复制其他西奈山核心实验室提供的服务，而是利用并利用这些服务。 补充其他核心，例如我们的临床转化科学奖 (CTSA) 资助的核心，并促进 总体而言，西奈山 P30 核心中心的 IHSFC 至关重要。 资源，使研究人员能够建立高效和协作的团队，以解决 环境对整个生命过程健康的影响。