Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)

肌肉骨骼生物学和医学资源中心（整体应用）

基本信息

批准号：
10388079
负责人：
MATTHEW J SILVA
金额：
$ 75.5万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10388079
关键词：
Address Adult Affect Age American Animal Model Animals Anti-Inflammatory Agents Area Arthralgia Arthritis Award Back Pain Basic Science Behavior Biological Biological Testing Biology Biomechanics Cancer Grant Supplements (P30)Cartilage Cells Collaborations Communities Confocal Microscopy Degenerative polyarthritis Development Disease Disseminated Malignant Neoplasm Engineering Epigenetic Process Evaluation Fostering Funding Goals Grant Histology Impairment Interdisciplinary Study Intervention Knowledge Leadership Ligaments Maintenance Measures Medicine Metastatic Neoplasm to the Bone Methods Microscopy Morphology Motion Muscle Musculoskeletal Musculoskeletal Diseases Musculoskeletal structure National Institute of Arthritis and Musculoskeletal and Skin Diseases Natural regeneration Osteoporosis Paper Population Productivity Protocols documentation Publications Publishing Reproducibility Research Research Personnel Research Support Resources Rheumatoid Arthritis Roentgen Rays Sampling Series Serum Services Stains Techniques Tendon structure Testing Time Tissue Banks Tissues Training Training Support Translational Research United States United States National Institutes of Health Universities University resources Washington Work arthropathies base bone bone mass cellular imaging cost cost effective imaging modality improved in vivo joint function joint injury mechanical properties morphometry mouse model next generation outreach preclinical study prevent professor programs recruit symposium therapeutic development tissue processing

项目摘要

Summary/Abstract - Overall One in two adults in the United States has a prevalent musculoskeletal condition, with related costs of $900 billion annually. To address this crisis, efficient utilization of resources and sustained commitment to basic and translational research are essential. We propose the Washington University Resource-Based Center for Musculoskeletal Biology and Medicine, dedicated to two long-term goals – to advance research on the biological basis of musculoskeletal disease, and to develop and test biologically based intervention strategies. We represent a dynamic Research Community of 81 investigators, affiliated with 17 academic departments. Since 2009, the Center has contributed to 343 publications that have been cited 6687 times. The annual external funding of Center investigators is $66.2 million, including $8.1 million from NIAMS. Our work focuses on the most prevalent and costly musculoskeletal disorders – arthritis, back pain, bone and joint trauma, osteoporosis, and metastatic cancer. Notably, the majority of our research endeavors are in basic and pre-clinical studies. Therefore, our overall objective is to support the Research Community in the development, implementation and evaluation of animal models for musculoskeletal biology and medicine. We will address this objective through four integrated Aims. Aim 1. Through an Administrative Core (A), provide Center leadership to manage the Cores and engage in outreach. Direct an Enrichment Program that will foster the development of the next generation of musculoskeletal investigators through a Pilot & Feasibilty program, seminars, symposia and other activities. Aim 2. Through the Musculoskeletal Structure and Strength Core (B), support access, training and cost-effective utilization for: i) x-ray based imaging methods to quantify morphology, and ii) biomechanical methods to quantify mechanical properties of musculoskeletal tissues (bone, tendon, muscle, cartilage, disc). Aim 3. Through the Musculoskeletal Histology and Morphometry Core (C), perform tissue processing, embedding, sectioning and staining, protocol maintenance and user training appropriate for the range of tissues/techniques required in musculoskeletal research. Support access and training for routine and advanced microscopy and histomorphometry. Aim 4. In the Animal Models of Joint Injury and Disease Core (D), provide training and implementation for reproducible mouse models of osteoarthritis and rheumatoid arthritis. Measure in vivo biomechanics and behavior to assess joint pain and function. Create a repository of tissue and serum samples from arthritic mouse models. In summary, the four Cores we propose will provide essential support for our Research Community to develop, implement and evaluate animal models for musculoskeletal biology and medicine. A common theme for each Core is to support training and enrichment activities to foster development of the next generation of musculoskeletal investigators.

摘要/摘要 - 总体美国有二分之一的成年人患有普遍的肌肉骨骼疾病，相关费用为 900 美元每年数十亿美元，以解决这一危机，有效利用资源和持续致力于基本。我们建议建立华盛顿大学资源中心。肌肉骨骼生物学和医学，致力于两个长期目标——推进关于肌肉骨骼生物学和医学的研究肌肉骨骼疾病的生物学基础，并开发和测试基于生物学的干预措施我们代表了一个由 81 名研究人员组成的充满活力的研究社区，隶属于 17 名学者。自2009年以来，中心已发表论文343篇，被引用6687次。中心研究人员的年度外部资助为 6620 万美元，其中包括来自 NIAMS 的 810 万美元。工作重点是最普遍和最昂贵的肌肉骨骼疾病——关节炎、背痛、骨痛和值得注意的是，我们的研究工作主要涉及关节创伤、骨质疏松症和转移性癌症。因此，我们的总体目标是支持研究界。肌肉骨骼生物学和医学动物模型的开发、实施和评估。我们将通过四个综合目标来实现这一目标 1. 通过行政核心 (A)，提供中心领导来管理核心并参与外展计划。这将通过试点和培训促进下一代肌肉骨骼研究人员的发展可行性计划、研讨会、座谈会和其他活动目标 2. 通过肌肉骨骼结构。和力量核心 (B)，支持以下方面的访问、培训和经济高效的利用： i) 基于 X 射线的成像量化形态的方法，以及 ii) 量化机械性能的生物力学方法肌肉骨骼组织（骨、肌腱、肌肉、软骨、椎间盘）。目标 3. 通过肌肉骨骼。组织学和形态测定核心 (C)，执行组织处理、包埋、切片和染色，适合所需组织/技术范围的协议维护和用户培训支持常规和高级显微镜检查和肌肉骨骼研究的访问和培训。目标 4. 在关节损伤和疾病核心 (D) 动物模型中，提供训练和实施可重复的骨关节炎和类风湿性关节炎小鼠模型体内测量。通过生物力学和行为来评估关节疼痛和功能。总之，我们提出的四个核心将提供必要的支持。供我们的研究社区开发、实施和评估肌肉骨骼动物模型每个核心的一个共同主题是支持培训和丰富活动促进下一代肌肉骨骼研究人员的发展。