Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology

西北大学心理健康，早期：精神病理学神经发育机制的跨诊断、跨学科、转化培训项目

• 批准号: 10205465
• 负责人: Stewart Aaron Shankman
• 金额: $ 24.62万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10205465
• 关键词: Mental Health; Psychopathology; Training Programs; Universities

Project Summary This T32 proposal will establish an innovative transdisciplinary postdoctoral training program focusing on transdiagnostic, neurodevelopmental mechanisms of psychopathology, with an expanded focus on developmental and environmental influences - program title: Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology (NU-MHE). Specifying malleable neurodevelopmental mechanisms of psychopathology at key developmental inflection points has proven elusive, suggesting that innovative methods and frameworks are necessary in order to advance intervention and prevention efforts. Approaches like NIMH’s Research Domain Criteria (RDoC) initiative, frame mental disorders as neurodevelopmental phenomena which emerge during an unfolding sequence from vulnerability to clinical symptomatology. This has led to novel research heuristics and designs which move away from conventional, discrete disease-based models towards more multi-level, transdiagnostic, transdisciplinary, approaches. However, the field is lacking training paradigms that effectively capture this dynamic, multi-faceted nature. This T32 thus proposes a novel training paradigm that bridges research in neurodevelopmental mechanisms of mental disorder with adjacent domains of high translational significance. Fellows will develop expertise in neurodevelopmental mechanisms of psychopathology, taking into account developmental and environmental contexts. Additionally, fellows will acquire foundational knowledge in the following core competencies: (1) computational psychiatry and other data science applications to mental health, (2) intervention/prevention/implementation science, (3) intersection of mental health and pediatric physical conditions – as well as the following professional development competencies, (4) translational team science, (5) ethical and responsible conduct of clinical research (which includes attentiveness to diversity), (6) grantsmanship, supporting a K or R-level grant submission, and (7) leadership and other career development skills. To achieve these competencies, at least 85% of the fellows’ time will be spent in mentored independent research. All fellows will have two co-mentors: A co-mentor with expertise in neurodevelopmental mechanisms of psychopathology; and a co-mentor in one of the following areas: (a) prevention, intervention, or implementation, (b) computational psychiatry and data science, or (c) the intersection of mental and pediatric health. These research experiences will be complemented by seminars in neurodevelopmental mechanisms of psychopathology, data science/computational psychiatry, as well as experiential learning (e.g., research in the context of real world care). Fellows will also make use of the rich educational resources available at NU, including professional development training in grant writing, team science skills, mentoring others, rigor and reproducibility, and other resources dedicated to career development. NU-MHE is well-positioned to launch the next generation of neurodevelopmental clinical scientists and leaders poised to accelerate the pace of clinical translation.

项目摘要 该T32提案将建立创新的跨学科博士后培训计划，重点介绍 经诊断，心理病理学的神经发育机制，扩大了对 发展和环境影响 - 计划标题：西北大学心理健康，早期： 神经发育机制的转诊，跨学科，翻译培训计划 心理病理学（NU-MHE）。指定心理病理的可延展神经发育机制 关键的发展影响点已被证明难以捉摸，这表明创新的方法和框架是 为了推进干预和预防工作所必需的。 NIMH的研究领域等方法 标准（RDOC）倡议，将精神障碍作为神经发育现象，在 从脆弱性到临床症状学的展开顺序。这导致了新的研究启发式和 从常规的，基于疾病的模型转向更多层次的设计， 转诊，跨学科的方法。但是，该领域缺乏有效的培训范例 捕获这种动态的，多方面的性质。因此，该T32提出了一个新颖的训练范式，该范式桥梁 具有高转化的相邻领域的精神障碍神经发育机制的研究 意义。研究员将在心理病理学的神经发育机制方面发展专业知识， 帐户发展和环境环境。此外，研究员将获得基础知识 以下核心竞争力：（1）计算精神病学和其他数据科学应用于心理 健康，（2）干预/预防/实施科学，（3）心理健康与小儿交集 身体状况 - 以及以下专业发展能力，（4）转化团队 科学，（5）临床研究的道德和负责任的行为（包括对多样性的关注），（6） 授予技巧，支持K或R级赠款提交，以及（7）领导和其他职业发展 技能。为了实现这些能力，至少有85％的同龄人的时间将用于修订独立 研究。所有研究员都将有两个副主持人：一个具有神经发育机制专业知识的联合主管 心理病理学；以及以下一个领域之一中的联盟者：（a）预防，干预或 实施，（b）计算精神病学和数据科学，或（c）精神和小儿的交集 健康。这些研究经验将由神经发育机制的精确完成 精神病理学，数据科学/计算精神病学以及专家学习（例如，研究 现实世界护理的背景）。研究员还将利用NU可用的丰富教育资源，包括 赠款写作，团队科学技能，指导他人，严格和可重复性的专业发展培训， 以及致力于职业发展的其他资源。 Nu-Mhe的位置很好，可以推出下一代 神经发育临床科学家和领导者中毒以加速临床翻译的速度。