Family Study of Reward and Threat Sensitivity in Internalizing Psychopathology

内化精神病理学中奖励和威胁敏感性的家庭研究

基本信息

批准号：
8545900
负责人：
Stewart Aaron Shankman
金额：
$ 65.57万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-14 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8545900
关键词：
Accounting Acute Address Affective Age Anxiety Behavior Behavioral Cardiovascular system Categories Communities DSM-IV Deceleration Diagnostic Dimensions Early Intervention Educational workshop Electroencephalography Family Family Study Fright Genes Heart Rate Heterogeneity Interview Joints Laboratories Learning Measures Mental Depression Methods Motivation National Institute of Mental Health Nature Nomenclature Panic Paper Patient Self-Report Physiological Play Prevention Psychopathology Psychophysiology Public Health Recording of previous events Recruitment Activity Relative (related person)Research Rewards Risk Risk Factors Risk Marker Role Siblings Sinus Arrhythmia Staging Study models Symptoms Testing Theoretical model Uncertainty Variant cost depressive symptoms neural circuit novel strategies proband public health relevance respiratory response therapy development transmission process treatment response vigilance

项目摘要

DESCRIPTION (provided by applicant): The purpose of this study is to examine whether two transdiagnostic dimensions - reduced reward anticipation (RRA) and heightened sensitivity to potential threat (SPT) - represent risk factors for internalizing (i.e., depression and anxiety) psychopathology. The proposed project is significant because internalizing psychopathologies are very heterogeneous, raising questions as to the validity of the categorical diagnostic nomenclature (e.g., DSM-IV). This study therefore takes the Research Domain Criteria (RDoC) approach and seeks to identify underlying dimensional constructs that cut across traditional categories of psychopathology. However, the proposed project extends the aims of RDoC by examining whether the proposed dimensional constructs reflect 1) risk markers for psychopathology (defining risk via the classic family study method) and 2) separable constructs (i.e., the discriminant validity of RDoC constructs). Specifically, we hypothesize that RRA (but not SPT) will predict risk for depressive symptomatology and SPT (but not RRA) will predict risk for certain anxiety symptoms (e.g., panic). We will recruit 210 probands with a wide range of internalizing psychopathology from the community and assess RRA and SPT using multiple physiological, behavioral, and self-report measures. Our primary indicators of RRA and SPT will be EEG alpha asymmetry while anticipating reward and startle response while anticipating a potential threat, respectively. These psychophysiological variables have been used extensively as measures of RRA and SPT and both tap anticipatory affective states, thus sharpening our test of discriminant validity. In addition, the startle task assesses sensitivity to acute threat a well as potential threat and therefore allows a test of the discriminant validity of RRA and SPT from this third RDoC construct (acute threat). The study aims to examine: 1) whether RRA and SPT predict family history (assessed via direct interview of 1st degree relatives) of separable facets of internalizing psychopathology; 2) whether indicators of RRA and SPT are abnormal in 'healthy' (or low symptom) age-matched siblings of probands with high levels of internalizing symptoms; 3) the familial aggregation of RRA and SPT; and 4) the construct validity of our electrophysiological measures of RRA and SPT using cardiovascular, behavioral, and self- report indicators of these two constructs. The impact of the study would be in identifying important underlying mechanisms that play a role in the etiopathogeneses of internalizing psychopathology. In addition, if these indicators prove to be familial markers of risk for psychopathology, they would make excellent (and relatively inexpensive) laboratory targets for prevention/early intervention efforts as well as targets for treatment development studies.

描述（由申请人提供）：本研究的目的是检查两个经诊断的维度 - 减少奖励预期（RRA）和对潜在威胁（SPT）的敏感性提高 - 代表内在化（即抑郁和焦虑症）精神病理学的风险因素。拟议的项目之所以重要，是因为内在的心理病理学是非常异质的，因此提出了有关分类诊断命名法的有效性的问题（例如DSM-IV）。因此，这项研究采用了研究领域标准（RDOC）方法，并试图识别跨越传统心理病理类别的基本尺寸结构。但是，拟议的项目通过检查提出的维构建体是否反映了心理病理学的风险标记（通过经典的家庭研究方法定义风险）和2）可分离构建体（即RDOC构建体的判别有效性）来扩展RDOC的目标。具体来说，我们假设RRA（但不是SPT）将预测抑郁症状的风险，而SPT（但不是RRA）将预测某些焦虑症状的风险（例如，恐慌）。我们将从社区招募具有广泛内在的心理病理学的210个概率，并使用多种生理，行为和自我报告措施评估RRA和SPT。我们的RRA和SPT的主要指标将是EEG Alpha不对称性，同时预期奖励和惊吓，同时预期潜在的威胁。这些心理生理变量已被广泛用作RRA和SPT的度量，并且都掌握了预期的情感状态，从而加强了我们对判别有效性的检验。此外，惊吓任务评估对急性威胁的敏感性以及潜在的威胁，因此可以测试第三个RDOC结构（急性威胁）中RRA和SPT的判别有效性。该研究的目的是检查：1）RRA和SPT是否可以预测内在心理病理学的可分离方面的家族史（通过对一级亲戚的直接访谈进行评估）； 2）RRA和SPT的指标是否在“健康”（或低症状）年龄匹配的兄弟姐妹中是否异常具有高水平的内在症状； 3）RRA和SPT的家族聚集； 4）使用这两种构建体的心血管，行为和自我报告指标，我们对RRA和SPT进行电生理测量的构造有效性。该研究的影响将在确定重要的基本机制中，这些机制在内在的心理病理学的病原体中发挥作用。此外，如果这些指标被证明是心理病理学风险的家族标志，则它们将成为预防/早期干预工作以及治疗开发研究目标的出色（相对便宜）的实验室目标。