Training in Sleep, Circadian, and Respiratory Neurobiology

睡眠、昼夜节律和呼吸神经生物学培训

• 批准号: 10204074
• 负责人: Charles A Czeisler
• 金额: $ 99.14万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10204074
• 关键词: Neurobiology; Sleep; Training; circadian; respiratory

ABSTRACT In its most recent research plan, the NHLBI's National Center for Sleep Disorders Research identified the need to train investigators as its highest priority. The Harvard Medical School Division of Sleep Medicine Program for Training in Sleep, Circadian and Respiratory Neurobiology, based at the Brigham and Women's Hospital, has been addressing this need since 1998 and has been modified to address the new challenges in our field. This program provides structured, comprehensive research training to prepare outstanding individuals for academic positions in the broad field of sleep science and sleep and circadian medicine. For each trainee, the training program consists of core required courses and activities, elective courses and activities, and an intensive research experience. Cross-disciplinary and translational research is a highlight of this program, and formal mentoring and tracking components are integral features. Intensive research training experiences are available across the breadth of sleep, circadian and respiratory neurobiology areas, including basic as well as clinical and translational research opportunities, with two program projects that span multiple laboratories and institutions. There are 15 Full Preceptors with extensive experience and demonstrated success at training pre- doctoral and post-doctoral fellows, well-funded research programs (training faculty have current research support totaling nearly $30 million of direct costs per year), and outstanding resources that trainees will utilize for research. In addition, we have 17 Associate Preceptors who also oversee our trainees, and are actively being trained to be our next generation of mentors. Our program also has 3 Affiliate Preceptor mentors who provide direct research supervision and research career development related to his or her areas of expertise. Our training record over the past decade reveals the success of our efforts to train leaders in academic sleep science. Of our pre- and post-doctoral trainees funded by this training grant over the last 10 years, 90% of our pre-doctoral trainees remain in academic/research-intensive careers, and 94% of our post-doctoral trainees remain in academic/research-intensive careers, with a full 75% of our post-doctoral trainees remaining in academic medicine (still in academic training or now in faculty positions). Of those still in academic medicine, almost all have a faculty rank of Assistant Professor or higher, and more than 50% have already received external grant support as PI or Co-I, with the remainder well on their way to independence. These data indicate that this training program is very effective at selecting and training scientists who have productive careers in research. Funds are requested to support four pre-doctoral graduate students, three pre-doctoral short-term summer minority medical students and eight post-doctoral trainees. Based on our highly competitive application process, we are confident these slots will be filled by outstanding future leaders. This formal program has grown and been refined over the two decades since its inception, and meets a nationally recognized need to increase the number of highly qualified investigators in sleep and circadian science and sleep disorders medicine.

抽象的 NHLBI 国家睡眠障碍研究中心在其最新的研究计划中确定需要 培训调查人员作为其首要任务。哈佛医学院睡眠医学项目部 布莱根妇女医院的睡眠、昼夜节律和呼吸神经生物学培训 自 1998 年以来一直在满足这一需求，并进行了修改以应对我们领域的新挑战。这 该计划提供结构化、全面的研究培训，为杰出的个人做好学术准备 在睡眠科学以及睡眠和昼夜节律医学的广泛领域中占有一席之地。对于每位学员来说，培训 课程包括核心必修课程和活动、选修课程和活动以及强化课程 研究经验。跨学科和转化研究是该项目的一大亮点，正式的 指导和跟踪组件是不可或缺的功能。提供强化研究培训经验 横跨睡眠、昼夜节律和呼吸神经生物学领域，包括基础以及临床和 转化研究机会，有两个跨越多个实验室和机构的计划项目。 有 15 名全职导师，他们在博士前和博士生培训方面拥有丰富的经验并取得了成功。 博士后研究员，资金充足的研究项目（培训教师拥有当前的研究支持总计 每年近 3000 万美元的直接成本），以及学员将用于研究的优秀资源。在 此外，我们还有 17 名副导师，他们也负责监督我们的学员，并正在积极接受培训，以成为 我们的下一代导师。我们的项目还有 3 名附属导师导师，他们提供直接研究 监督和研究与其专业领域相关的职业发展。我们的训练记录结束了 过去十年展示了我们在培养睡眠科学学术领导者方面所付出的努力所取得的成功。我们的前期和后期 近10年受本培养补助金资助的博士后学员占我们博士前学员的90% 继续从事学术/研究密集型职业，94% 的博士后学员继续从事学术/研究密集型职业 学术/研究密集型职业，我们 75% 的博士后学员仍从事学术工作 医学（仍在接受学术培训或现在担任教职）。在那些仍在学术医学领域的人中，几乎所有 具有助理教授以上职称，50%以上获得过外部资助 作为 PI 或 Co-I 提供支持，其余人正在走向独立。这些数据表明，本次培训 该计划在选择和培训在研究领域富有成效的科学家方面非常有效。资金有 要求资助四名博士前研究生、三名博士前短期暑期少数民族医学生 学生和八名博士后实习生。基于我们极具竞争力的申请流程，我们有信心 这些空缺将由杰出的未来领导者填补。这个正式的计划已经发展并完善了 自成立以来已有二十年了，满足了国家认识到的增加高度人才数量的需要 睡眠和昼夜节律科学以及睡眠障碍医学领域的合格研究人员。