Neonatal predictors of contextualized emotion processing and risk for anxiety

情境化情绪处理和焦虑风险的新生儿预测因素

• 批准号: 10600450
• 负责人: Maria Catalina Camacho
• 金额: $ 6.87万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600450
• 关键词: Age; Anxiety; Anxiety Disorders; Attention; Behavior assessment; Birth; Brain; Chad; Child; Chronic; Complex; Coupled; Cues; Data; Detection; Development; Disease; Early Intervention; Emotional; Emotions; Etiology; Familiarity; Functional Magnetic Resonance Imaging; Functional disorder; Grant; Image; Individual Differences; Infant; Link; Longitudinal Studies; Measures; Mental Depression; Mental Health; Mental disorders; Methods; Mothers; Neonatal; Newborn Infant; Process; Public Health; Regulation; Risk; Sampling; Sleep; Stimulus; Symptoms; Temperament; Testing; Training; Variant; Work; Writing; Youth; auditory stimulus; behavioral response; design; developmental neurobiology; emotional experience; emotional stimulus; high risk; infancy; infant temperament; insight; maternal anxiety; neonatal brain; neonate; neural; neurodevelopment; novel; parent grant; response; skills; training opportunity; visual tracking

PROJECT SUMMARY Depression and anxiety are associated with overlapping dysfunctions in emotion processing, but the etiology is not well understood. Individual differences during infancy in negative temperament—a global measure of a child’s emotional reactivity and regulation tendencies—are associated with increased risk for depression and anxiety. Thus, the emotional dysfunction linked to depression and anxiety appears to begin during early infancy, yet the associated developmental neurobiology is poorly understood. A central barrier to unlocking the developmental neurobiology of emotion dysfunction is we do not know how variation in brain function at birth relates to emotion processing later in infancy, and whether this relation depends on infant temperament. Contextualized emotion processing—processing emotions in the real-world, with competing stimuli and full narrative context—is complex and includes: 1) detection of and attention towards salient stimuli; 2) interpretation and contextualization of this information; and 3) making a behavioral response. Depression and anxiety have been associated with dysfunctions at all three stages, and emerging evidence suggesting that some of these dysfunctions are present at birth. Recent work has found that the variation in newborn brain activation during saliency processing—the first stage of emotion processing—is associated with risk for anxiety. While this links early variation in saliency processing to risk trajectories for anxiety and depression, the developmental sequence is unknown. This study is therefore designed to identify how neonatal brain function is associated with contextualized emotion processing during infancy. This project will add an additional measure to the ongoing Neonatal Predictors of Anxiety Disorders Study (N-PAD; R01MH122389 PI: Sylvester, sponsor), a longitudinal study of mothers and infants. This current grant will substantially increase the impact of the parent grant by adding a video-watching eye-tracking task to the 24-month assessment, allowing us to measure attention to contextualized emotional stimuli. Our central hypothesis is that neonatal activation to salient stimuli (measured with fMRI) predicts attention to contextualized emotional stimuli during infancy (measured with eye tracking), and this relation is strengthened in infants with negative temperaments. Results will provide important insights to how internalizing symptoms emerge across early development. Through this project, the candidate will develop critical expertise in infant neural and behavioral assessments.

项目摘要 抑郁和动画与情感处理中的重叠功能障碍有关，但病因是 不太了解。婴儿期在负温度下的个体差异 - 全球测量 孩子的情绪反应性和调节趋势与增加抑郁风险和 焦虑。那就与抑郁和焦虑有关的情绪功能障碍似乎在早期开始 婴儿期，但相关的发育神经生物学知之甚少。解锁的中心障碍 情绪功能障碍的发展神经生物学是我们不知道出生时大脑功能的变化如何 与情绪处理的关系后来在婴儿期，以及这种关系是否取决于婴儿温度。 情绪处理 - 通过竞争刺激和充实的现实世界中的情感处理 叙事背景 - 很复杂，包括：1）对显着刺激的发现和注意力； 2） 该信息的解释和上下文化； 3）做出行为反应。抑郁和 焦虑在所有三个阶段都与功能障碍有关，并有新兴的证据表明 这些功能障碍中有一些出生时存在。最近的工作发现新生儿大脑的变化 显着处理过程中的激活（情感处理的第一阶段）与风险有关 焦虑。尽管这将显着性处理的早期变化与动画和抑郁的风险轨迹联系起来，但 发展序列未知。因此，这项研究旨在确定新生儿大脑的功能 与婴儿期间情绪处理有关。该项目将增加一个 测量正在进行的焦虑症研究的新生儿预测指标（N-PAD； R01MH122389 PI：Sylvester，Sylvester， 赞助商），一项对母亲和婴儿的纵向研究。目前的赠款将大大增加 父母的赠款通过在24个月的评估中添加视频观看视频吸引力的任务，从而使我们能够 测量对情境化刺激的注意。我们的中心假设是新生儿激活 显着刺激（用fMRI测量）预测对上下文化情绪刺激的关注 婴儿期（通过眼动追踪测量），并且在患有阴性的婴儿中加强了这种关系 温度。结果将为内部化符号如何早期出现提供重要的见解 发展。通过这个项目，候选人将在婴儿神经元和行为方面发展重要的专业知识 评估。