Biospecimen Procurement and Translational Pathology Shared Resource Facility

生物样本采购和转化病理学共享资源设施

基本信息

批准号：
10204884
负责人：
Therese Jeanne Bocklage
金额：
$ 14.05万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-08 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10204884
关键词：
Ambulatory Care Facilities Animals Appalachian Region Area Award Back Basic Science Bioinformatics Biological Assay Biological Markers Biological Models Biometry Blood Cancer Center Cancer Center Support Grant Clinical Clinical Cancer Center Clinical Data Clinical Research Clinical Sciences Clinical Trials Collaborations Collection Communities Comprehensive Cancer Center Computer software Consent Consultations Custom DNA Data Databases Department chair Development Education Ensure Evaluation Faculty Familiarity Formalin Fostering Freezing Fresh Tissue Funding Future Genetic Genetic Markers Genomics Goals Growth Guidelines Histologic Histology Histopathology Hospitals Human Immunohistochemistry In Situ In Situ Hybridization Informatics Institutional Review Boards Kentucky Laboratories Laboratory Research Lasers Leadership Liquid substance Malignant Neoplasms Medicine Metabolic Microscopy Mission Modeling NCI Center for Cancer Research Names Obesity associated cancer Operative Surgical Procedures Organoids Outcome Paraffin Embedding Pathologic Pathologist Pathology Patient Care Patients Peer Review Play Population Procedures Protocols documentation RNA Research Research Design Research Personnel Research Training Resistance Resource Sharing Resources Retrospective Studies Role SEER Program Sampling Science Scientist Services Site Slice Specimen Standardization Structure Students Therapeutic Clinical Trial Therapeutic Human Experimentation Time Tissue Banks Tissue Embedding Tissue Microarray Tissues Training Training and Education Translating Translational Research Tumor Tissue United States Office of Research Integrity Universities Work anticancer research biological specimen archives biomarker evaluation cancer health disparity cancer immunotherapy clinical center clinical investigation cohort consent capacity digital imaging direct patient care faculty support histological stains human tissue imaging system innovation interest investigator-initiated trial member metabolomics molecular pathology neoplasm registry next generation novel operation patient derived xenograft model patient population patient privacy population based precision medicine clinical trials preservation professor programs prospective repository response sample collection tissue biomarkers tumor tumor immunology tumor metabolism

项目摘要

PROJECT SUMMARY/ABSTRACT The Biospecimen Procurement and Translational Pathology Shared Resource Facility (BPTP SRF) is a Markey Cancer Center (MCC)-managed resource. It facilitates the use of well-annotated human and animal specimens and provides a wide range of translational pathology technical services in support of MCC clinical, translational, population-based and basic science research. Over the award period, the BPTP SRF has increased annual biospecimen dispensation from 1,738 in FY12 to 4,446 in FY17 (156% increase), increased the total number of MCC users by 23% (48 in FY17, up from 39 in FY12) including 38 peer-reviewed funded MCC users in FY17 (49% of all BPTP users) and expanded its range of services. New services include: targeted and time sensitive collections, such as intra-operative, rapid fresh tissue collections supporting work in cancer metabolism; the development of novel model systems (e.g., Warburg tissue slices for metabolic analysis, patient-derived xenograft, organoids); review of all clinical trials, including investigator-initiated trials, to identify specimen collection needs and develop collection protocols; fresh tissue collections and rapid blood processing for clinical trials, resulting in support for 40 clinical trials over the funding period. The addition of a research histology laboratory, operated per clinical guidelines, allows for an increased capacity for technical services, such as histology, immunohistochemistry, molecular pathology, laser capture microscopy and DNA/RNA extraction. BPTP SRF has increased its consent capacity through the cross training of all BPTP SRF staff, as well as by using a universal opt-in consent for repository collections. BPTP SRF's name change reflects its increased focus on translational pathology, facilitated by the support of faculty in the University of Kentucky (UK) Department of Pathology who assist BPTP SRF staff in the development and interpretation of novel assays, on-site evaluation of specimen content and quality for fresh tissue dispense and identification of retrospective study and tissue microarray cohorts from surgical archive specimens dating back to 1995. This partnership, strengthened by BPTP's leadership—C. Darrell Jennings, MD, chair of the Department of Pathology and Laboratory Medicine, with Associate Director Qiuying Shi, MD, Assistant Professor in Pathology—ensures MCC investigators have a clear path to the specimen resources and pathologic services essential to their work. The BPTP SRF has streamlined operations by transitioning to the OnCore database and adding a manager to oversee daily operations, leveraging existing resources within the MCC, including the Clinical Research Office, the Surveillance, Epidemiology and End Results Kentucky Cancer Registry and Cancer Research Informatics and Biostatistics and Bioinformatics SRFs, as well as non-MCC entities, such as the Department of Pathology and Laboratory Medicine, UK Office of Research Integrity and the Center for Clinical and Translational Science.

项目概要/摘要生物样本采购和转化病理学共享资源设施 (BPTP SRF) 是一个马基癌症中心 (MCC) 管理的资源有助于使用注释良好的人类和动物。标本并提供广泛的转化病理学技术服务以支持 MCC 临床、在奖励期间，BPTP SRF 进行了转化、基于人群的基础科学研究。年度生物样本分配量从 2012 财年的 1,738 份增加到 2017 财年的 4,446 份（增加 156%），增加 MCC 用户总数增加了 23%（2017 财年为 48 人，2012 财年为 39 人），其中包括 38 名经过同行评审的资助者 2017 财年 MCC 用户（占所有 BPTP 用户的 49%）并扩大了其服务范围新服务包括：有针对性和时间敏感的收集，例如术中快速新鲜组织收集支持工作癌症代谢；新型模型系统的开发（例如用于代谢的 Warburg 组织切片）分析、患者来源的异种移植、类器官）；审查所有临床试验，包括研究者发起的试验，确定样本采集需求并制定新鲜组织采集和快速血液采集方案；处理临床试验，从而在资助期内支持 40 项临床试验。研究组织学实验室，按照临床指南运行，可以提高技术能力服务，例如组织学、免疫组织化学、分子病理学、激光捕获显微镜和 DNA/RNA提取。BPTP SRF通过所有BPTP的交叉训练提高了其同意能力。 SRF 工作人员，以及使用 BPTP SRF 名称更改的通用选择同意。在伦敦大学教师的支持下，它更加关注转化病理学肯塔基州（英国）病理学部协助 BPTP SRF 工作人员制定和解释新颖的测定方法、现场评估新鲜组织分配的样本内容和质量以及鉴定来自 1995 年手术档案标本的回顾性研究和组织微阵列队列。 BPTP 的领导加强了伙伴关系——Darrell Jennings 医学博士，系主任病理学和检验医学，副主任史秋英，医学博士，助理教授病理学——确保 MCC 研究人员有清晰的途径获取标本资源和病理服务 BPTP SRF 通过过渡到 OnCore 数据库简化了操作。并增加一名经理来监督日常运营，利用 MCC 内的现有资源，包括临床研究办公室、监测、流行病学和最终结果肯塔基州癌症登记处和癌症研究信息学、生物统计学和生物信息学 SRF，以及非 MCC 实体，例如英国研究诚信办公室和中心病理学和检验医学系临床和转化科学。