Human Tissue Repository Shared Resource

人体组织库共享资源

基本信息

批准号：
8545082
负责人：
Therese Jeanne Bocklage
金额：
$ 6.3万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8545082
关键词：
American Applications Grants Archives Aspirate substance Blood specimen Bone Marrow Cancer Center Cataloging Catalogs Client satisfaction Clinical Clinical Data Collection Conflict (Psychology)Core Facility Cryoultramicrotomy Cytology Cytopathology DNA Data Diagnosis Environment Equilibrium Ethics Fellowship Focus Groups Formalin Freezing Funding Future Generations Genomics Goals Health Sciences Hematoxylin and Eosin Staining Method Histology Human Human Resources Immunohistochemistry Individual Institutional Review Boards Laboratories Lasers Link Location Microscopy New Mexico Normal tissue morphology Operative Surgical Procedures Paraffin Paraffin Embedding Pathologist Pathology Patient Rights Patients Peer Review Physician Executives Positioning Attribute Preparation Process Proteins Proteomics Protocols documentation Publications Quality Control RNA Recovery Regulation Reporting Research Research Personnel Research Support Residencies Resource Sharing Resources Retrieval Safety Sampling Serum Services Site Slide Societies Solid Solid Neoplasm Southwest Oncology Group Specimen Staining method Stains Surgical Pathology Surveys Techniques Therapeutic Tissue Banking Tissue Banks Tissue Microarray Tissue Sample Tissues Training Tumor Tissue Universities Whole Blood abstracting anticancer research base breast cancer registry cancer research center director cancer therapy college cost data mining experience human tissue medical schools medical specialties member operation outcome forecast patient privacy posters professor programs quality assurance repository tissue fixing tissue processing treatment center tumor virtual web site

项目摘要

OVERVIEW: The University of New Mexico Human Tissue Repository (HTR) is a shared central resource that provides tissue collection, processing, refinement and distribution of paraffin-embedded tissues, frozen tissues, and selected serum and bone marrow samples. It also serves as a central site for coordination of tissue banking activities for "satellite" tissue banks. These satellite banks include UNM-based specialty tissue banks and large cooperative group-focused tissue banks that are located at UNM. Ancillary services include clinical data mining, retrieval and return of surgical pathology archived paraffin-embedded formalin fixed tissue blocks, cryosectioning, paraffin sectioning, tissue processing and, since the last grant application, laser capture microscopy, tissue microarray block preparation, virtual slide generation and immunohistochemical staining. The Resource Director, Therese Bocklage MD, is a Professor in the UNM School of Medicine, Department of Pathology with 18 years of experience in Surgical and Cytopathology, including Laboratory Director of Cytopathology for four years. College of American Pathologists Laboratory Inspector, and 11 years experience in other administrative positions (Residency Program Director for the Department of Pathology, and Cytopathology Fellowship Director). As an annually approved IRB reviewed facility, the Resource collects human tumor and normal tissue in a manner that preserves the tissue for future research, especially genomics and proteomics, for diagnosis, prognosis and therapeutics following NCI Best Practices for Biospecimen Resources, issued in 2007. Whole blood and serum samples are also collected (via satellites) and stored in the core facility. In compliance with NCI Best Practices for Biospecimen Resources, 2007, the HTR conducts a systematic quality assurance and quality control program. The Resource collects tissue in a manner that protects the patient's rights and privacy yet provides the greatest possible longitudinal clinical information, maximizing the value of the tissue and balancing the sometimes inherent ethical conflicts between the needs of the patient and the researchers. The Resource reports to the Cancer Center Director, the Chair of Pathology and the Health Science Center Associate Dean for Research via the Human Tissue Oversight Committee. HTR goals include 1) accruing 10,000 high quality specimens by 2012, 2) increasing distribution by 30% yearly, and 3) achieving 25% cost recovery by 2012.

概述：新墨西哥大学人体组织存储库 (HTR) 是一个共享的中央资源，提供石蜡包埋组织、冷冻组织以及选定的血清和骨髓样本的组织收集、处理、精制和分配。它还充当协调“卫星”组织库的组织库活动的中心站点。这些卫星库包括位于新墨西哥州的专业组织库和位于新墨西哥州的大型合作团体组织库。辅助服务包括临床数据挖掘、检索和返回手术病理存档的石蜡包埋福尔马林固定组织块、冷冻切片、石蜡切片、组织处理，以及自上次拨款申请以来，激光捕获显微镜、组织微阵列块制备、虚拟载玻片生成和免疫组织化学染色。资源总监 Therese Bocklage 医学博士是新墨西哥大学医学院病理学系的教授，在外科和细胞病理学领域拥有 18 年经验，其中包括四年的细胞病理学实验室主任。美国病理学家学院实验室检查员，并拥有 11 年其他行政职位经验（病理科住院医师项目主任和细胞病理学研究员主任）。作为每年批准的 IRB 审查机构，该资源收集人类肿瘤和正常组织，并按照 2007 年发布的 NCI 生物样本资源最佳实践保存组织用于未来研究，特别是基因组学和蛋白质组学、诊断、预后和治疗。全血和血清样本也被收集（通过卫星）并存储在核心设施中。根据 2007 年 NCI 生物样本资源最佳实践，HTR 实施了系统的质量保证和质量控制计划。该资源以保护患者权利和隐私的方式收集组织，同时提供尽可能多的纵向临床信息，最大化组织的价值并平衡患者和研究人员的需求之间有时固有的道德冲突。该资源通过人体组织监督委员会向癌症中心主任、病理学主席和健康科学中心研究副院长报告。 HTR 目标包括 1) 到 2012 年积累 10,000 个高质量样本，2) 每年增加 30% 的分布，以及 3) 到 2012 年实现 25% 的成本回收。