Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Pittsburgh

创新紧急护理临床试验网络 (SIREN) 的策略 - 匹兹堡

• 批准号: 10200902
• 负责人: Clifton W. Callaway
• 金额: $ 14.72万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200902
• 关键词: Accident and Emergency department; Acute Lung Injury; Ambulances; Biological; Cardiac; Cardiopulmonary Resuscitation; Caring; Clinical; Clinical Sciences; Clinical Trials; Clinical Trials Network; Collaborations; Communication; Conduct Clinical Trials; Consent; Critical Care; Critical Illness; Data; Databases; Early treatment; Electronic Health Record; Emergency Care; Emergency Medicine; Emergency Situation; Emergency department visit; Emergency medical service; Emergency research; Emergency treatment; Enrollment; Ensure; Event; Faculty; Funding; Future; Geographic Locations; Geography; Growth; Health; Health Technology; Health system; Healthcare Systems; Heart Arrest; Hospitals; Informed Consent; Infrastructure; Institutes; Institutional Review Boards; Intensive Care Units; Intervention; Investigator-Initiated Research; Knowledge; Leadership; Medicine; Methods; Modeling; Multi-Institutional Clinical Trial; Multicenter Trials; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Neurological emergencies; Operative Surgical Procedures; Outcome; Patient Rights; Patients; Pennsylvania; Pre-hospital setting; Prehospital Emergency Care; Prevention; Protocols documentation; Pulmonology; Reporting; Research; Research Personnel; Resources; Resuscitation; Rural; Scientist; Sepsis; Signal Transduction; Site; Structure; System; Telemedicine; Testing; Text Messaging; Time; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Work; academic program; acute care; clinical care; clinical research site; cost; data management; electronic data; emergency settings; experience; improved; innovation; mHealth; meetings; member; novel; recruit; remote consent; screening; signal processing; skills; suburb; telepresence; tool; treatment research; treatment strategy; treatment trial

The Pennsylvania Consortium for Emergency Research will leverage our experience and infrastructure to participate in the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The University of Pittsburgh will act as a Hub with strong academic and clinical partners at the Thomas Jefferson University, Allegheny Health Network, and the Pennsylvania State University. Each partner is affiliated with a health system that can provide additional clinical sites within the region for future growth. This geographically tight collaboration, with access to emergency patients and emergency medical services in rural, suburban and urban parts of Pennsylvania, will participate in network emergency care trials with the following Aims: (1) Provide administrative structure to rapidly implement and enroll in clinical trials of emergency treatments. (2) Minimize time, cost and regulatory barriers to multicenter clinical trials in emergency settings. (3) Explore innovative strategies to increase identification, recruitment, and consent in emergency treatment trials. (4) Explore innovative strategies to increase quality of emergency care data and to ensure retention of subjects enrolled in emergency settings. The investigators have established working relationships to conduct clinical trials and are leaders in cardiac and neurological emergencies. Through experience in prior research networks and investigator initiated research, this site has created efficient research staffing models, toolkits and telemedicine approaches to emergency informed consent, novel mobile health strategies for subject retention, special skill with prehospital electronic data, and unique integration of critical care and emergency medicine. These efficiencies and innovations will be shared and are scalable for SIREN.

宾夕法尼亚紧急研究联盟将利用我们的经验和基础设施 参与创新紧急护理临床试验网络策略 (SIREN)。大学 匹兹堡大学将作为托马斯·杰斐逊强大的学术和临床合作伙伴的中心 大学、阿勒格尼健康网络和宾夕法尼亚州立大学。每个合作伙伴都隶属于 一个可以在该地区提供更多临床场所以促进未来发展的卫生系统。这 地理上紧密的合作，可以在以下地区获得紧急患者和紧急医疗服务 宾夕法尼亚州的农村、郊区和城市部分，将与 以下目标： (1) 提供管理结构以快速实施和注册临床试验 紧急治疗。 (2) 最大限度地减少多中心临床试验的时间、成本和监管障碍 紧急设置。 (3) 探索创新策略，以增加识别、招募和同意 紧急治疗试验。 （四）探索提高急救数据质量的创新策略 并确保保留在紧急情况下登记的受试者。调查人员已确定 进行临床试验的工作关系，并且是心脏和神经紧急情况的领导者。 通过先前研究网络的经验和研究者发起的研究，该网站创建了 有效的研究人员配置模型、工具包和紧急知情同意的远程医疗方法， 用于保留受试者的新颖的移动医疗策略、院前电子数据的特殊技能以及独特的 重症监护和急诊医学的整合。这些效率和创新将被共享和 对于 SIREN 来说是可扩展的。