Neurological Emergencies Treatment Trial (NETT) Network Pittsburgh Clinical Hub

神经急症治疗试验 (NETT) 网络匹兹堡临床中心

• 批准号: 8527867
• 负责人: Clifton W. Callaway
• 金额: $ 30.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8527867
• 关键词: Accident and Emergency department; Acute; Agreement; Area; Caring; Cessation of life; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Computerized Medical Record; Conduct Clinical Trials; Country; Craniocerebral Trauma; Critical Care; Data Coordinating Center; Development; Electronics; Emergency Medicine; Emergency Situation; Emergency treatment; Enrollment; Environment; Faculty; Health system; Hospitals; Individual; Informatics; Informed Consent; Intensive Care Units; Leadership; Learning; Medicine; Mentorship; Modeling; Monitor; Morbidity - disease rate; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Nervous System Trauma; Neurological emergencies; Neurological outcome; Neurology; Neurosciences; Neurosurgical Procedures; Operative Surgical Procedures; Outcome; Outcome Measure; Patients; Performance; Physical Medicine; Postdoctoral Fellow; Protocols documentation; Qualifying; Records; Recruitment Activity; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Resuscitation; Rural; Services; Spinal Injuries; Spinal cord injury; Stroke; Structure; System; Telemedicine; Testing; Time; Training; Trauma; Traumatic Brain Injury; Universities; Work; base; career; clinical research site; design; disability; experience; follow-up; member; mortality; nervous system disorder; neurosurgery; next generation; outreach; patient population; programs; public health priorities; tertiary care; treatment trial; waiver

DESCRIPTION (provided by applicant): Clinical trials to test treatments of neurological disorders are a public health priority to reduce mortality and morbidity. Consortiums to provide infrastructure and reduce start-up time for this testing will facilitate the performance of clinica trials and preselect clinical sites with specific expertise relevant for specific types of trials. he University of Pittsburgh has extensive resources and expertise in studying emergency conditions, and specifically neurological emergencies. Therefore, Pittsburgh can serve effectively as a new Clinical Hub for the Neurological Emergencies Treatment Trial (NETT) network. Drawing on longstanding collaborations between Emergency Medicine, Neurology, Neurosurgery, Critical Care Medicine, Physical Medicine and Rehabilitation, the University of Pittsburgh will successfully achieve the following aims: (Aim 1) Create a structured team for collaboration with the NETT Network on the development and implementation of clinical trials about neurological emergencies. The leadership of the Pittsburgh NETT team will maintain working relationships with the NETT steering committee, Clinical Coordinating Center, Data Coordination Unit and NINDS staff. (Aim 2) Enroll subjects in NETT clinical trials and disseminate research findings resulting from NETT activities. Pittsburgh will maintain the administrative and contractual structure to participate rapidly in NETT trials. Experienced research coordinators and staff will be tasked with identification of eligible subjects for NETT trials, will enroll subjects according to NETT protocols, and will maintain the detailed records required for auditing of compliance. Existing media and electronic resources will be expanded to further disseminate research findings.

描述（由申请人提供）：测试神经系统疾病治疗方法的临床试验是降低死亡率和发病率的公共卫生优先事项。为该测试提供基础设施并减少启动时间的联盟将促进临床试验的进行，并预先选择具有与特定类型试验相关的特定专业知识的临床地点。匹兹堡大学在研究紧急情况，特别是神经系统紧急情况方面拥有丰富的资源和专业知识。因此，匹兹堡可以有效地充当神经急症治疗试验（NETT）网络的新临床中心。凭借急诊医学、神经病学、神经外科、重症监护医学、物理医学和康复领域之间的长期合作，匹兹堡大学将成功实现以下目标：（目标 1）创建一个结构化团队，与 NETT 网络合作开发和实施神经急症临床试验。匹兹堡NETT团队的领导层将与NETT指导委员会、临床协调中心、数据协调部门和NINDS工作人员保持工作关系。 （目标 2）让受试者参加 NETT 临床试验并传播 NETT 活动的研究结果。匹兹堡将维持行政和合同结构，以快速参与 NTT 试验。经验丰富的研究协调员和工作人员将负责确定符合 NETT 试验资格的受试者，根据 NETT 协议招募受试者，并维护合规性审核所需的详细记录。将扩大现有媒体和电子资源，以进一步传播研究成果。