Biobehavioral basis of knee osteoarthritis pain

膝骨关节炎疼痛的生物行为基础

基本信息

批准号：
10353418
负责人：
Yenisel Cruz-Almeida
金额：
$ 53.58万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10353418
关键词：
Address Affect Age Aging Behavioral Biological Biological Aging Biological Markers Biological Process Black Populations Blood Blood Cells Brain Cell Aging Cells Characteristics Chronology Clinical Cognitive Complex DNA Methylation Degenerative polyarthritis Development Disease Elderly Epigenetic Process Ethnic group Fibrinogen Florida Future Goals Health Heterogeneity Individual Intervention Knee Osteoarthritis Knowledge Length Leukocytes Longevity Measures Methods Modeling Morbidity - disease rate Mosaicism Not Hispanic or Latino Outcome Pain Pain intensity Pain management Pain-Free Pattern Performance Personality Traits Persons Phase II Clinical Trials Physical Function Physiological Population Group Process Race Reporting Research Residual state Risk System Therapeutic Time Tissues Underrepresented Minority Universities Validation Visit Work age related aging brain biobehavior biological heterogeneity biopsychosocial candidate marker chronic pain clinical pain clinically relevant cognitive function disability disorder risk experience follow-up functional decline functional disability functional outcomes improved in vivo inter-individual variation knee pain loss of function middle age mortality neuroimaging non-opioid analgesic novel osteoarthritis pain pain inhibition pain relief pain sensitivity personalized predictions predictive marker predictive modeling prospective psychologic psychosocial racial and ethnic racial difference racial disparity social telomere trait

项目摘要

Project Summary/Abstract. Discovery and validation of strong candidate biomarkers and clinical endpoints for pain is urgently needed that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials. Emerging research using a combination of biomarkers deliver individualized predictions about future brain and body health. Our own findings suggest that behavioral chronic pain characteristics are associated with multiple biological biomarkers where a greater pain burden is associated with accelerated detrimental biological processes. However, prospective research is urgently needed to determine pain’s impact on the heterogeneity of these biological processes within an individual to elucidate the underlying patterns of biological changes using a biobehavioral perspective which is needed for predicting future health and to be able to use as clinical endpoints for interventions. The proposed study will prospectively address biobehavioral factors (i.e., cognitive, psychological, social and cultural) affecting the experience and interpretation of knee pain and physical function across racial/ethnic groups over time. We will prospectively assess pain along with multiple biomarkers as predictors of cognitive, psychological and physical functional progression among middle-aged and older non- Hispanic Blacks and non-Hispanic Whites with knee pain and controls over a four-year study period. With strong support from the University of Florida, our interdisciplinary project, using a comprehensive biobehavioral multi- methods approach, we will be the first to prospectively determine the trajectory and interactions among pain, biological biomarkers and multiple domains of function within race/ethnic groups in OA pain. Findings will contribute towards increased understanding of pain and its biobehavioral basis, with the potential to reduce race/ethnic group disparities and improve pain-related health and functional outcomes.

项目摘要/摘要。迫切需要发现和验证强效生物标志物候选物和疼痛的临床终点可用于促进非阿片类疼痛疗法从发现到 II 期临床的开发使用生物标志物组合的新兴研究提供了对未来大脑的个性化预测。我们自己的研究结果表明，慢性疼痛的行为特征与身体健康有关。多种生物标志物，其中更大的疼痛负担与加速的生物劣势相关然而，迫切需要前瞻性研究来确定疼痛对异质性的影响。个体内部的这些生物过程，以阐明生物变化的潜在模式预测未来健康并能够用作临床所需的生物行为视角拟议的研究将前瞻性地解决生物行为因素（即认知、心理、社会和文化）影响膝关节疼痛和身体功能的体验和解释随着时间的推移，我们将前瞻性地评估跨种族/族裔群体的疼痛以及多种生物标志物。中老年人认知、心理和身体功能进展的预测因素在四年的研究期间，患有膝盖疼痛的西班牙裔黑人和非西班牙裔白人的情况得到了很好的控制。来自佛罗里达大学的支持，我们的跨学科项目，使用综合的生物行为多方法方法，我们将成为第一个前瞻性地确定疼痛之间的轨迹和相互作用的人， OA 疼痛的生物标志物和种族/民族群体内的多个功能域。有助于增进对疼痛及其生物行为基础的了解，并有可能减少种族/民族差异并改善与疼痛相关的健康和功能结果。