NOSI: Biobehavioral basis of knee osteoarthritis pain

NOSI：膝骨关节炎疼痛的生物行为基础

• 批准号: 10331506
• 负责人: Yenisel Cruz-Almeida
• 金额: $ 21.35万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10331506
• 关键词: Address; Affect; Age; Aging; Behavioral; Biological; Biological Aging; Biological Markers; Biological Process; Blood Cells; Brain; Cell Aging; Cells; Characteristics; Chronology; Clinical; Cognitive; Complex; DNA Methylation; Data; Development; Elderly; Epigenetic Process; Ethnic group; Fibrinogen; Florida; Future; Goals; Health; Heterogeneity; Individual; Intervention; Knee Osteoarthritis; Knowledge; Length; Leukocytes; Longevity; Measures; Methods; Modeling; Morbidity - disease rate; Mosaicism; Not Hispanic or Latino; Outcome; Pain; Pain intensity; Pain management; Pattern; Performance; Personality Traits; Persons; Phase II Clinical Trials; Physical Function; Population Group; Process; Race; Reporting; Research; Residual state; Risk; System; Therapeutic; Time; Tissues; Underrepresented Populations; Universities; Validation; Visit; Woman; Work; age related; aging brain; biobehavior; biological heterogeneity; black women; candidate marker; chronic pain; clinical pain; clinically relevant; disability; disorder risk; disparity reduction; experience; follow-up; functional decline; functional disability; functional outcomes; improved; in vivo; inter-individual variation; knee pain; loss of function; middle age; mortality; non-opioid analgesic; novel; osteoarthritis pain; pain inhibition; pain relief; pain sensitivity; parent grant; personalized predictions; predictive marker; predictive modeling; prospective; psychologic; psychosocial; racial and ethnic; racial difference; social; telomere; trait

Project Summary/Abstract. Discovery and validation of strong candidate biomarkers and clinical endpoints for pain is urgently needed that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials. Emerging research using a combination of biomarkers deliver individualized predictions about future brain and body health. Our own findings suggest that behavioral chronic pain characteristics are associated with multiple biological biomarkers where a greater pain burden is associated with accelerated detrimental biological processes. However, prospective research is urgently needed to determine pain’s impact on the heterogeneity of these biological processes within an individual to elucidate the underlying patterns of biological changes using a biobehavioral perspective which is needed for predicting future health and to be able to use as clinical endpoints for interventions. The proposed study will prospectively address biobehavioral factors (i.e., cognitive, psychological, social and cultural) affecting the experience and interpretation of knee pain and physical function across racial/ethnic groups over time. We will prospectively assess pain along with multiple biomarkers as predictors of cognitive, psychological and physical functional progression among middle-aged and older non- Hispanic Blacks and non-Hispanic Whites with knee pain and controls over a four-year study period. With strong support from the University of Florida, our interdisciplinary project, using a comprehensive biobehavioral multi- methods approach, we will be the first to prospectively determine the trajectory and interactions among pain, biological biomarkers and multiple domains of function within race/ethnic groups in OA pain. Findings will contribute towards increased understanding of pain and its biobehavioral basis, with the potential to reduce race/ethnic group disparities and improve pain-related health and functional outcomes.

项目摘要/摘要。 迫切需要发现和验证强有力的候选生物标志物和疼痛临床终点 可用于促进从发现到II期临床的非阿片类药物疼痛疗法的发展 试验。结合生物标志物提供有关未来大脑的个性化预测的新兴研究 和身体健康。我们自己的发现表明行为慢性疼痛特征与 多种生物学生物标志物，其中更大的疼痛灼伤与加速有害生物学有关 过程。但是，迫切需要进行前瞻性研究以确定疼痛对异质性的影响 在一个个体内的这些生物学过程中，以使用生物学变化的基本模式 一种生物行为的观点，可以预测未来健康并能够用作临床 干预措施的终点。拟议的研究可能会解决生物行为因素（即认知， 心理，社会和文化）影响膝盖疼痛和身体机能的经验和解释 随着时间的流逝，种族/族裔群体。我们可能会评估疼痛以及多种生物标志物 中年和旧非 - 的认知，心理和身体功能进展的预测 在四年的研究期间，西班牙裔黑人和非西班牙裔白人膝盖疼痛和控制。坚强 我们的跨学科项目佛罗里达大学的支持，使用全面的生物行为多 方法方法，我们将是第一个确定疼痛之间的轨迹和相互作用的人 OA疼痛中种族/族裔群体内的生物生物标志物和功能的多个领域。调查结果会 有助于增加对疼痛及其生物行为基础的理解，有可能减少 种族/族裔群体分布并改善与疼痛有关的健康和功能结果。