Skeletal Phenotyping Core

骨骼表型核心

基本信息

批准号：
10183171
负责人：
MARY L BOUXSEIN
金额：
$ 28.16万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-19 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10183171
关键词：
Achievement Address Animals Applications Grants Architecture Area Award Biology Bone remodeling Clinical Clinical Investigator Collaborations Communities Consultations Core Facility Data Data Analyses Disease Education Educational process of instructing Educational workshop Ensure Evaluation Experimental Designs Fostering Genetic Goals Histology Human Individual Infrastructure Activities Institution Intervention Knowledge Mechanics Mentors Mentorship Methods Mission Molecular Morphology New England New York Pharmacology Phenotype Process Productivity Publications Quality Control Research Research Peer Review Research Personnel Research Project Grants Research Support Resource Sharing Services Specimen Specimen Handling Structure Sum Techniques Technology Therapeutic Time Training Training and Education Translating Update bone bone cell bone imaging bone mass career cost effective cost efficient design experience experimental study in vivo innovation interest member new technology novel peer support ranpirnase single-cell RNA sequencing skeletal skeletal disorder success synergism testing services

项目摘要

Identification of the structural, architectural, cellular and molecular basis for the skeletal phenotypes that result from genetic/pharmacologic interventions and disease states is essential for translating scientific discoveries into therapeutic innovations. The goal of the Skeletal Phenotyping Core is to provide cost-efficient, state of the art, quality-controlled skeletal phenotyping services, continuing to fulfill the unmet needs of early stage investigators who are transitioning to an independent career in skeletal biology, of established investigators who are new to skeletal biology and of established skeletal biologists. Key missions of the Skeletal Phenotyping Core include education, mentoring and incorporation of novel and innovative services to meet the needs of the constituent investigators. Consultation regarding experimental design, specimen handling and data analysis is provided by Core directors, to ensure that the maximal amount of data can be obtained from each specimen/subject. The Core will conduct didactic teaching sessions, hands-on workshops and seminars designed to educate investigators and to foster collaboration among investigators. A special focus of the Core will continue to be mentorship of early stage investigators and of those investigators new to skeletal biology. This infrastructure and these activities will continue to: 1) enhance the productivity and expand the scope of research being conducted by the Core investigators, 2) promote innovation and incorporation of novel technologies into core services, 3) foster synergy across a large and diverse community interested in skeletal research, ultimately leading to levels of success greater than the sum of the individual investigators’ projected achievements. These goals will be achieved by two specific aims: Aim 1) Provide efficient, high-quality, state- of-the-art skeletal phenotyping services that are not readily supported by individual research grants in a timely fashion; Aim 2) Provide training, and educational services to support new investigators in skeletal biology and to facilitate collaboration among core investigators. In summary, the Skeletal Phenotyping Core will continue to enhance the research productivity of a large and diverse community of investigators in skeletal biology by ensuring accurate, efficient and comprehensive analyses of skeletal phenotypes.

识别导致骨骼表型的结构，结构，细胞和分子基础来自遗传/药理干预措施和疾病状态对于翻译科学发现至关重要进入治疗创新。骨骼表型核心的目的是提供成本效益的状态艺术，质量控制的骨骼表型服务，继续满足早期的未满足需求既定研究者的调查人员正在过渡到骨骼生物学独立职业谁是骨骼生物学的新手和已建立的骨骼生物学家。骨骼的关键任务表型核心包括教育，心理和纳入服务以满足构建研究人员的需求。有关实验设计，标本处理和的咨询数据分析由核心主管提供，以确保可以从中获得最大数据量每个标本/主题。核心将举办教学教学课程，动手讲习班和半手旨在教育研究人员并促进调查人员之间的合作。核心的特别重点早期研究人员和骨骼生物学新任调查人员的心态将继续是。这些基础设施和这些活动将继续：1）提高生产率并扩大范围核心研究人员进行的研究，2）促进新颖的创新和保险进入核心服务的技术，3）在一个对骨骼感兴趣的大型社区中促进协同作用研究最终导致成功水平大于个人调查人员的预计总和成就。这些目标将通过两个具体目标来实现：目标1）提供高效，高质量，国家 - 艺术骨骼表型服务在及时受到个人研究赠款不容易支持时尚;目标2）提供培训和教育服务，以支持骨骼生物学的新研究者在核心调查人员中喜欢的合作。总而言之，骨骼表型核心将继续通过确保对骨骼表型的准确，高效和全面分析。