Mood, mother, and child: The psychobiology of dyadic resilience

情绪、母亲和孩子：二元复原力的心理生物学

• 批准号: 9979927
• 负责人: William Roger Mills-Koonce
• 金额: $ 61.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979927
• 关键词: 5 year old; Affect; Anxiety; Anxiety Disorders; Blinded; Child; Child Development; Child Rearing; Cognitive; Development; Ensure; Epigenetic Process; Executive Dysfunction; Exhibits; Exposure to; Follow-Up Studies; Genetic; Genetic Variation; Genotype; Goals; Growth; Health; Heterogeneity; Impaired cognition; Impairment; Individual; Infant; Internet; Intervention; Late pregnancy; Life; Longitudinal cohort study; Measures; Mediating; Mediator of activation protein; Mental Depression; Mission; Modeling; Moods; Mothers; National Institute of Child Health and Human Development; Nose; OXT gene; Outcome; Oxytocin; Participant; Pathway interactions; Phenotype; Physiology; Placebos; Play; Postpartum Period; Predictive Factor; Psychopathology; Public Health; Relapse; Research; Risk; Role; Sampling; School-Age Population; Trier Social Stress Test; Work; boys; caregiving; emotion regulation; executive function; experience; externalizing behavior; girls; high risk; hypothalamic-pituitary-adrenal axis; indexing; intergenerational; maternal anxiety; maternal depression; novel strategies; peripartum depression; prevent; protective factors; psychobiologic; psychobiology; psychosocial; psychosocial adjustment; resilience; sex; stress reactivity; transmission process

ABSTRACT: MOOD, MOTHER AND CHILD: THE PSYCHOBIOLOGY OF DYADIC RESILIENCE Perinatal depression (PND) affects more than 400,000 mother-infant dyads in the US each year, with devastating consequences. Mothers with PND exhibit reduced sensitivity to infant needs, increasing infant risk for impaired emotional regulation and insecure attachment. These dysregulated interactions in the first year of life are associated with impaired cognitive and socioemotional development, including child psychopathology and impaired executive function (EF). Mothers who experience PND are more likely to have continuing or relapsing depression and anxiety disorders, conferring further risk. Nevertheless, despite exposure to PND, some dyads emerge intact. The long-term goal of this research is to identify the psychobiological underpinnings of resilience among mother-child dyads exposed to PND and longer-term maternal depression and anxiety trajectories (MDATs). The objectives of this proposal are to characterize MDAT heterogeneity during the first 5 years of the child’s life, to identify mediators that explain the mechanisms through which MDATs influence child outcomes, and identify moderators that may serve as intervention points for promoting dyadic resilience. We will leverage an existing pool of participants in the Mood, Mother and Infant (MMI) study (R01HD073220, mmi.web.unc.edu, PI Stuebe), an ongoing longitudinal cohort study that we have led of mother-infant dyads (N=222) who have been extensively phenotyped during the first postpartum year. Our central hypothesis is that oxytocin plays a central role in dyadic development, indexed by associations between OT psychobiology, genetics and epigenetics and both MDATs and child development outcome. The rationale for this work is that our findings will inform targeted interventions to facilitate resilience and diminish the sequelae of maternal depression. We will accomplish the objective of our application by pursuing the following specific aims via an MMI follow-up study, the Mood, Mother and Child (MMC) study: 1) Elucidate the role of OT in the maternal psychobiological underpinnings of MDATs and parenting behavior, including effects of exogenous oxytocin (OT) on HPA axis reactivity; 2) Determine psychosocial mediators and moderators of associations between MDATs and child developmental outcome; and 3) Determine the extent to which child OXT and OXTR genotype moderates associations between MDATs, sensitivity, attachment quality, and developmental outcome; quantify the extent to which child epigenetic changes in OT and OXTR mediate associations between MDATs and developmental outcome. The expected outcomes of this work will be the determination of both predictive and protective factors for mother-infant dyads affected by depression and anxiety, laying the groundwork for novel approaches to promote resilience. Such results will have a positive impact by informing interventions to prevent intergenerational transmission of depression and anxiety.

摘要：心情，母子：二元弹性的心理生物学 围产期抑郁症（PND）每年在美国影响40万多名母子二元组 毁灭性后果。 PND暴露的母亲降低了对婴儿需求的敏感性，增加了婴儿风险 为了受损的情绪调节和不安全的依恋。这些失调的互动在第一年的第一年 生活与认知和社会情感发展受损有关，包括儿童心理病理学 和执行功能受损（EF）。经历PND的母亲更有可能继续或 复发抑郁和焦虑症，会议进一步风险。但是，目的地暴露于PND， 一些二元组完好无损。这项研究的长期目标是确定心理生物学 暴露于PND和长期母校抑郁症的母子二元组之间的弹性基础 和焦虑轨迹（MDAT）。该提案的目标是表征MDAT异质性 在孩子一生的前5年中 MDAT会影响儿童的结果，并确定可以作为促进的干预点的主持人 二元弹性。我们将利用情绪，母亲和婴儿（MMI）研究来利用现有的参与者池 （R01HD073220，mmi.web.unc.edu，pi stuebe），一项正在进行的纵向人群研究，我们已经领导 在产后第一个年份进行了广泛表型的母亲二元组（n = 222）。我们的 中心假设是催产素在二元发展中起着核心作用，这是由 OT心理生物学，遗传学和表观遗传学以及MDAT和儿童发展结果。理由 这项工作是，我们的发现将为有针对性的干预措施提供促进的韧性并降低 孕产妇抑郁症的后遗症。我们将通过追求以下内容来实现我们应用的目标 通过MMI随访研究，情绪，母亲和儿童（MMC）研究的具体目标：1）阐明了OT的作用 在MDAT和育儿行为的母亲心理生物学基础中，包括 HPA轴反应性上的外源性催产素（OT）； 2）确定社会心理调解人和主持人 MDAT与儿童发育成果之间的关联； 3）确定孩子的程度 OXT和OXTR基因型调节MDAT之间的关联，灵敏度，依恋质量和 发展结果；量化儿童表观遗传在OT和OXTR介导的程度 MDAT与发展结果之间的关联。这项工作的预期结果将是 确定受抑郁影响和 焦虑，为促进弹性的新方法奠定了基础。这样的结果将有积极的 通过告知干预措施以防止抑郁和动画的代际传播来影响。