Mood, mother, and child: The psychobiology of dyadic resilience

情绪、母亲和孩子：二元复原力的心理生物学

基本信息

批准号：
10215574
负责人：
William Roger Mills-Koonce
金额：
$ 59.03万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-07 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10215574
关键词：
5 year old Affect Anxiety Anxiety Disorders Blinded Child Child Development Child Rearing Cognitive Development Ensure Epigenetic Process Executive Dysfunction Exhibits Exposure to Follow-Up Studies Genetic Genetic Variation Genotype Goals Growth Health Heterogeneity Impaired cognition Impairment Individual Infant Internet Intervention Late pregnancy Life Longitudinal cohort study Measures Mediating Mediator of activation protein Mental Depression Mission Modeling Moods Mothers National Institute of Child Health and Human Development Nose OXT gene Outcome Oxytocin Participant Pathway interactions Phenotype Physiology Placebos Play Postpartum Period Predictive Factor Psychopathology Public Health Relapse Research Risk Role Sampling School-Age Population Trier Social Stress Test Work boys caregiving emotion regulation executive function experience externalizing behavior girls high risk hypothalamic-pituitary-adrenal axis indexing intergenerational maternal anxiety maternal depression novel strategies peripartum depression prevent protective factors psychobiologic psychobiology psychosocial psychosocial adjustment resilience sex stress reactivity transmission process

项目摘要

ABSTRACT: MOOD, MOTHER AND CHILD: THE PSYCHOBIOLOGY OF DYADIC RESILIENCE Perinatal depression (PND) affects more than 400,000 mother-infant dyads in the US each year, with devastating consequences. Mothers with PND exhibit reduced sensitivity to infant needs, increasing infant risk for impaired emotional regulation and insecure attachment. These dysregulated interactions in the first year of life are associated with impaired cognitive and socioemotional development, including child psychopathology and impaired executive function (EF). Mothers who experience PND are more likely to have continuing or relapsing depression and anxiety disorders, conferring further risk. Nevertheless, despite exposure to PND, some dyads emerge intact. The long-term goal of this research is to identify the psychobiological underpinnings of resilience among mother-child dyads exposed to PND and longer-term maternal depression and anxiety trajectories (MDATs). The objectives of this proposal are to characterize MDAT heterogeneity during the first 5 years of the child’s life, to identify mediators that explain the mechanisms through which MDATs influence child outcomes, and identify moderators that may serve as intervention points for promoting dyadic resilience. We will leverage an existing pool of participants in the Mood, Mother and Infant (MMI) study (R01HD073220, mmi.web.unc.edu, PI Stuebe), an ongoing longitudinal cohort study that we have led of mother-infant dyads (N=222) who have been extensively phenotyped during the first postpartum year. Our central hypothesis is that oxytocin plays a central role in dyadic development, indexed by associations between OT psychobiology, genetics and epigenetics and both MDATs and child development outcome. The rationale for this work is that our findings will inform targeted interventions to facilitate resilience and diminish the sequelae of maternal depression. We will accomplish the objective of our application by pursuing the following specific aims via an MMI follow-up study, the Mood, Mother and Child (MMC) study: 1) Elucidate the role of OT in the maternal psychobiological underpinnings of MDATs and parenting behavior, including effects of exogenous oxytocin (OT) on HPA axis reactivity; 2) Determine psychosocial mediators and moderators of associations between MDATs and child developmental outcome; and 3) Determine the extent to which child OXT and OXTR genotype moderates associations between MDATs, sensitivity, attachment quality, and developmental outcome; quantify the extent to which child epigenetic changes in OT and OXTR mediate associations between MDATs and developmental outcome. The expected outcomes of this work will be the determination of both predictive and protective factors for mother-infant dyads affected by depression and anxiety, laying the groundwork for novel approaches to promote resilience. Such results will have a positive impact by informing interventions to prevent intergenerational transmission of depression and anxiety.