Long-term consequences of SARS-CoV-2 infection and COVID-19 disease among American Indians: an ambidirectional cohort study in the Cherokee Nation

美洲印第安人中 SARS-CoV-2 感染和 COVID-19 疾病的长期后果：切罗基族的双向队列研究

• 批准号: 10707064
• 负责人: Katrin Gaardbo Kuhn
• 金额: $ 34.52万
• 依托单位: CHEROKEE NATION
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707064
• 关键词: 5 year old; Acute; Address; Adult; Affect; Age; American; American Indians; Anxiety; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 patient; COVID-19 risk; COVID-19 test; Cardiovascular system; Caring; Cessation of life; Cherokee Indian; Child; Child Health; Clinic; Cohort Studies; Coin; Communities; Community Surveys; Contact Tracing; Dedications; Disease; Dizziness; Eligibility Determination; Fatigue; Future; Gender; Goals; Guidelines; Health; Health care facility; Healthcare; Healthcare Systems; Heart; Hospitalization; Incidence; Indian reservation; Infection; Intensive Care; Interview; Knowledge; Long COVID; Long-Term Effects; Medical; Memory; Mental Depression; Native American Research Center for Health; Oklahoma; Outpatients; Paper; Participant; Patient risk; Patients; Persons; Population; Prevalence; Public Health; Publishing; Questionnaires; Race; Reporting; Review Literature; Risk; SARS-CoV-2 infection; SARS-CoV-2 negative; SARS-CoV-2 positive; Severity of illness; Surveys; Symptoms; Telephone Interviews; Test Result; Testing; Time Study; Visit; cohort; comorbidity; coronavirus disease; experience; gastrointestinal; health inequalities; high risk; improved; long term consequences of COVID-19; long-term sequelae; member; mortality; pandemic disease; persistent symptom; post SARS-CoV-2 infection; post-COVID-19; primary care provider; prospective; psychologic; rural counties; severe COVID-19; symptom management; tribal community

ABSTRACT Following the immediate effect of acute COVID-19 on patients and healthcare systems, it has now also become apparent that as many as 35% of COVID patients experience long-term health consequences of their infection. These consequences are reported to include heart-related problems, digestive issues, fatigue and dizziness, as well as anxiety and depression, but the full spectrum of symptoms and their duration is still unknown. American Indian people have been disproportionately affected by the COVID pandemic due to underlying medical conditions combined with high COVID-19 incidence and mortality, and general health inequalities. As a result, the impact of long-term symptoms is also expected to be severe in this population. In this study, we propose to examine the extent of long-term symptoms following SARS-CoV-2 infection among American Indian people residing in the Cherokee Nation Reservation. Given the strong impact of COVID-19 and the lack of understanding of its long-term effect in the Cherokee Nation, there is a crucial need for improved management among these patients in the community. This study will be among the first to assess long-term symptoms in an American Indian population and as such will establish a precedent and framework for future studies in the American Indian population. The overall goal of the study is to identify and quantify long-term COVID symptoms among American Indian people and to develop guidelines for how to predict, assess and manage these symptoms. This is an ambidirectional cohort study following a total of 200 persons retrospectively (tested for infection within the past six months) and prospectively (tested for infection from the time the study is initiated, and onwards). Using this approach, we will achieve our aims of identifying long-term symptoms in SARS-CoV-2 positive versus negative American Indian persons, predicting who is at risk of developing these symptoms and ultimately produce guidelines for predicting and identifying who is most at risk of becoming affected by COVID symptoms in the long run and how manage the symptoms either in centralized dedicated healthcare clinics or through primary care providers.

抽象的 遵循急性共互联-19对患者和医疗保健系统的立即影响，现在也有 显然，多达35％ 感染。据报道，这些后果包括与心脏有关的问题，消化问题，疲劳和 头晕，焦虑和沮丧，但全部症状及其持续时间仍在 未知。美国印第安人受到因联合大流行而受到不成比例的 基本的医疗状况与高价值19号的发病率和死亡率以及一般健康状况相结合 不平等。结果，长期症状的影响也有望在该人群中很严重。在 这项研究，我们建议检查SARS-COV-2感染后长期症状的程度 居住在切诺基国家保留地的美洲印第安人。鉴于Covid-19的强烈影响 而且缺乏对切诺基国家的长期影响的理解，对 这些患者的管理改善了社区中的管理。这项研究将是最早评估的研究 美洲印第安人人口的长期症状，因此将建立先例和框架 用于对美洲印第安人人口的未来研究。该研究的总体目标是识别和量化 美洲印第安人的长期互联症状，并制定有关如何预测的准则 评估和管理这些症状。这是一项在共有200人之后进行的Ambidectional队列研究 回顾性（过去六个月内对感染进行了测试）和前瞻性（经过测试 开始研究的时间，并开始）。使用这种方法，我们将实现确定长期的目标 SARS-COV-2正面与负面印第安人的症状，预测谁有 制定这些症状，并最终制定预测和识别谁最有风险的准则 从长远来看会受到互联症状的影响，以及如何在集中式管理症状 专门的医疗诊所或通过初级保健提供者。