Tinnitus Treatment with Targeted Electric Stimulation

有针对性的电刺激治疗耳鸣

• 批准号: 9975629
• 负责人: Fan-Gang Zeng
• 金额: $ 32.83万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-16 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9975629
• 关键词: Acoustic Nerve; Acoustic Stimulation; Acoustics; Adhesives; Affect; American; Anxiety; Auditory; Auditory Perception; Basic Science; Biomedical Engineering; Charge; Clinical; Cochlear Implants; Cochlear implant procedure; Collaborations; Counseling; Development; Devices; Discontinuous Capillary; Disease; Ear; Electric Stimulation; Electrodes; Esthesia; External auditory canal; FDA approved; Gold; Hearing; Hearing Tests; Hour; Intervention; Knowledge; Lead; Loudness; Mastoid process; Measures; Medical; Medical Device; Mental Depression; Methods; National Institute on Deafness and Other Communication Disorders; Nature; Nerve Fibers; Neurosciences; Operative Surgical Procedures; Outcome; Patients; Pattern; Peripheral; Pharmaceutical Preparations; Physiologic pulse; Platinum; Principal Investigator; Procedures; Promontory; Protocols documentation; Public Health; Quality of life; Research Personnel; Research Project Grants; Services; Site; Sleep; Stimulus; Structure; Surface; Techniques; Tinnitus; Tragus; Translating; Tympanic membrane; Work; cost; daily functioning; disability; effective therapy; gang; hidden hearing loss; individual patient; innovation; minimally invasive; novel; programs; relating to nervous system; research and development; response; round window; skills; sound; tool

Principal Investigator/Program Director (Last, first, middle): Zeng, Fan-Gang Tinnitus is the perception of sound in the absence of external sound. Tinnitus is a significant public health problem that affects 50 million Americans. Severe tinnitus disrupts daily functions from sleep to work, often leading to anxiety, depression and lowered quality of life. Despite significant advances in research and development, presently there is no cure for tinnitus. The present application uses noninvasive electric stimulation in the ear and minimally-invasive electric stimulation to the round window or promontory for safe and effective treatment of tinnitus. One innovation is to evaluate stimulation sites and patterns that evoke auditory sensations while minimizing non-auditory sensations. Another innovation is to provide two novel tinnitus treatment options, especially for those who still have significant acoustic hearing and cite tinnitus, and not hearing loss, as the main indication. In the preliminary study, 10 minutes of round window stimulation completely silenced the tinnitus not only during stimulation but also for 5 hours after the stimulation in a subject who had suffered from tinnitus for 15 years. Successful completion of the present work can lead to safe and effective medical devices for tinnitus treatment. Project Summary

首席调查员/计划总监（最后，第一个，中间）：Zeng，粉丝甘恩 耳鸣是在没有外部声音的情况下对声音的感知。耳鸣是一个重要的公众 影响5000万美国人的健康问题。严重的耳鸣会破坏每日睡眠的功能 工作，通常导致焦虑，抑郁和降低生活质量。尽管取得了重大进展 研究与开发，目前无法治愈耳鸣。当前的应用程序使用 耳朵中的无创刺激和对圆形的微创电刺激 窗户或海角可安全有效地处理耳鸣。一种创新是评估 刺激位点和模式引起听觉感觉，同时最大程度地减少非听力感觉。 另一个创新是提供两个新颖的耳鸣治疗选择，尤其是对于那些仍然 具有明显的声学听力并引用耳鸣，而不是听力损失，这是主要的指示。在 初步研究，10分钟的圆窗刺激完全使耳鸣完全沉默 在刺激期间，但在患有耳鸣的受试者刺激后持续5个小时 15年。成功完成本工作可能会导致安全有效的医疗设备 耳鸣治疗。 项目摘要