Tinnitus Treatment with Targeted Electric Stimulation

有针对性的电刺激治疗耳鸣

• 批准号: 10121063
• 负责人: Fan-Gang Zeng
• 金额: $ 11.56万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-16 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10121063
• 关键词: Acoustic Stimulation; Administrative Supplement; Affect; Alzheimer' s disease related dementia; Auditory Perception; Award; Biological Markers; Cognition; Ear; Electric Stimulation; Electrical Stimulation of the Brain; Hearing problem; Impaired cognition; Monitor; Parents; Patients; Population; Principal Investigator; Protocols documentation; Research; Severities; Tinnitus; Work; cognitive development; gang; nonalzheimer dementia; programs

Principal Investigator/Program Director (Last, first, middle): Zeng, Fan-Gang ABSTRACT The present administrative supplement proposes to examine the relationship between tinnitus and cognition and to treat tinnitus in patients with Alzheimer's disease and related dementia (ADRD). Tinnitus is a hearing disorder that produces auditory perception without auditory stimulation and affects 13-52% of the ARDR population. Using the same experimental protocols as in the active parent award and building upon the preliminary work from a previous supplement, the proposed work will achieve the following specific aims. Specific Aim 1 will investigate the relationship between tinnitus and cognition in ADRD patients. We predict that tinnitus severity will be positively correlated with cognitive decline. Specific Aim 2 will use electric brain stimulation to treat tinnitus in the same patients. The main hypothesis is that, compared with typical non-ADRD subjects, the ADRD patients would require different electric stimulation parameters for optimal tinnitus suppression. We predict that dynamic brain electric stimulation will be more effective than steady-state ear electric stimulation in suppressing tinnitus in ADRD subjects. Tinnitus characterization may serve as a biomarker for monitoring the onset and progression of ADRD, while tinnitus suppression may delay or reduce cognitive decline and development of ADRD. Research Strategy

首席调查员/计划总监（最后，第一个，中间）：Zeng，粉丝甘恩 抽象的 目前的行政补充提议研究耳鸣与 认知和治疗阿尔茨海默氏病和相关痴呆症患者（ADRD）的耳鸣。 耳鸣是一种听力障碍，在没有听觉刺激和 影响ARDR人群的13-52％。使用与活动父母相同的实验协议 授予和基于以前补充剂的初步工作，拟议的工作将 实现以下特定目标。具体目标1将调查耳鸣之间的关系 和ADRD患者的认知。我们预测耳鸣的严重程度将与 认知能力下降。特定的目标2将使用电脑刺激来治疗同一耳鸣 患者。主要的假设是，与典型的非ADRD受试者相比，ADRD患者 将需要不同的电刺激参数才能最佳的耳鸣抑制。我们预测 动态的大脑电刺激将比稳态耳部电刺激更有效 在ADRD受试者中抑制耳鸣。耳鸣表征可以用作生物标志物 监视ADRD的发作和进展，而耳鸣抑制可能会延迟或减少 ADRD的认知下降和发展。 研究策略

项目成果

Human Sensation of Transcranial Electric Stimulation.

人类对经颅电刺激的感觉。

• DOI: 10.1038/s41598-019-51792-8
• 发表时间: 2019
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Zeng,Fan-Gang;Tran,Phillip;Richardson,Matthew;Sun,Shuping;Xu,Yuchen
• 通讯作者: Xu,Yuchen

Tele-Audiology: Current State and Future Directions.

• DOI: 10.3389/fdgth.2021.788103
• 发表时间: 2021
• 期刊: Frontiers in digital health
• 作者: D'Onofrio KL;Zeng FG
• 通讯作者: Zeng FG

Tinnitus Treatment Using Noninvasive and Minimally Invasive Electric Stimulation: Experimental Design and Feasibility.

使用无创和微创电刺激治疗耳鸣：实验设计和可行性。

• DOI: 10.1177/2331216518821449
• 发表时间: 2019
• 期刊: Trends in hearing
• 影响因子: 2.7
• 作者: Zeng,Fan-Gang;Richardson,Matthew;Tran,Phillip;Lin,Harrison;Djalilian,Hamid
• 通讯作者: Djalilian,Hamid

Tinnitus and hyperacusis: Central noise, gain and variance.

• DOI: 10.1016/j.cophys.2020.10.009
• 发表时间: 2020-12
• 期刊: Current opinion in physiology
• 影响因子: 2.5
• 作者: Zeng FG

Challenges in Improving Cochlear Implant Performance and Accessibility.

• DOI: 10.1109/tbme.2017.2718939
• 发表时间: 2017-08
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Zeng FG