Role and Mechanism of Hearing Impairment in Cognitive Decline and Dementia

听力障碍在认知衰退和痴呆中的作用和机制

• 批准号: 9974449
• 负责人: JENNIFER Anne DEAL
• 金额: $ 12.94万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9974449
• 关键词: Acoustic Stimulation; Address; Affect; Age; Aging; Air; Alzheimer' s Disease; Alzheimer' s disease brain; Amyloid beta-Protein; Ankle; Applications Grants; Appointment; Area; Atherosclerosis Risk in Communities; Attenuated; Audiology; Auditory; Award; Baltimore; Biological Markers; Blood Vessels; Brain; Brain imaging; Brain region; Cerebrovascular Disorders; Cerebrum; Clinic; Clinical; Clinical Research; Cognitive; Cognitive aging; Collection; Data; Data Analyses; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Disease Marker; Educational workshop; Elderly; Epidemiologist; Epidemiology; Five-Year Plans; Functional disorder; Funding; Fundus photography; Future; Goals; Head and Neck Surgery; Health; Healthcare; Hearing; Hearing Aids; Hearing Tests; Hypertension; Image; Impaired cognition; Individual; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Lacunar Infarctions; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mentors; Methods; Obesity; Observational Study; Otolaryngology; Participant; Pathology; Pathway interactions; Peripheral; Population Study; Positioning Attribute; Positron-Emission Tomography; Process; Publications; Publishing; Pure-Tone Audiometry; Reporting; Research; Research Personnel; Resources; Retina; Risk Factors; Role; Science; Scientist; Signal Transduction; Smoking; Structure; Techniques; Testing; Time; Training; Training Programs; United States National Academy of Sciences; United States National Institutes of Health; Universities; White Matter Hyperintensity; abeta deposition; adjudicate; adverse outcome; aging brain; auditory processing; aural rehabilitation; base; brain volume; career; cerebrovascular; clinical translation; cognitive function; cognitive neuroscience; cohort; disability; empowered; epidemiology study; healthy aging; hearing impairment; improved; indexing; informal learning; insight; medical schools; middle age; modifiable risk; mortality; neurocognitive test; neuroimaging; neuron loss; prevent; prospective; skills; tau Proteins; vascular factor; vascular risk factor; β-amyloid burden

ABSTRACT Jennifer A. Deal is an epidemiologist and gerontologist, with a position as Assistant Scientist in the Department of Epidemiology, Johns Hopkins Bloomberg School of Medicine and a secondary appointment in the Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine. She seeks a mentored career development award to fill knowledge gaps in her current training so that her research can successfully bridge the diverse fields of cognitive aging, audiology, otolaryngology, epidemiology and cognitive neuroscience in order to improve the health of older adults. The primary component of the training proposal includes a comprehensive five-year plan of formal and informal instruction in the acquisition, processing and analysis of neuroimaging data (structural MRI and PiB PET) in large population-based studies. The PI will also augment current knowledge about the collection and analysis of hearing data in epidemiologic studies with additional training in the clinical aspects and pathophysiology of hearing impairment. The training program consists of didactic coursework and seminars, clinic observations, and mentored research by an established and diverse team of experts. Short-term career goals include completion and dissemination of high-quality mentored research through publications and presentations and application for independent R01 funding beginning in the fourth year of the award period. Long-term career goals are to be an independent investigator in the area of aging and cognitive decline and dementia, with expertise in hearing impairment. The specific aims of the proposed research are to quantify the independent association of HI incident dementia and with domain-specific cognitive decline in three well-characterized prospective observational studies, to investigate the relationship of HI with changes in brain volume over time (both in regions related to Alzheimer's disease and to auditory processing), and to quantify the role of vascular factors in the development of HI. Completion of the proposed aims will elucidate the role and mechanism of hearing impairment in dementia and domain-specific cognitive decline, providing possible targets for future clinical research with the potential to inform efforts to prevent these adverse outcomes in older adults.

抽象的 Jennifer A. Deal是一名流行病学家和老年医生，在该部门担任助理科学家 流行病学，约翰·霍普金斯彭博医学院和次要任命 Johns Hopkins医学院耳鼻喉科头和颈部外科手术系。她寻求一个 指导的职业发展奖，以填补当前培训中的知识空白，以便她的研究可以 成功地弥合了认知衰老，听力学，耳鼻喉科，流行病学和认知的各种领域 神经科学以改善老年人的健康。 培训建议的主要组成部分包括全面的五年正式和非正式计划 在获取，处理和分析神经成像数据（结构MRI和PIB PET）中的指导 大型基于人群的研究。 PI还将增强有关收集和分析的当前知识 在流行病学研究中的听力数据，并在临床方面和病理生理学的其他培训 听力障碍。培训计划包括教学课程和研讨会，诊所观察， 并由一群成熟而多样的专家团队指导研究。短期职业目标包括 通过出版和演示完成和传播高质量的指导研究以及 从奖励期的第四年开始申请独立R01资金。长期职业 目标是成为衰老和认知能力下降和痴呆症领域的独立研究者，并且 听力障碍的专业知识。 拟议研究的具体目的是量化HI入射痴呆的独立关联 并在三个特征良好的前瞻性观察性研究中，域特异性认知能力下降， 调查HI与大脑体积随时间变化的关系（这两个地区都与阿尔茨海默氏症有关 疾病和听觉处理），并量化血管因素在HI发展中的作用。 拟议目标的完成将阐明听力障碍在痴呆症和 领域特异性的认知能力下降，为未来的临床研究提供了可能的靶标 为防止老年人的这些不良后果而努力。