Multimodal Musical Stimulation for Healthy Neurocognitive Aging

多模式音乐刺激促进健康的神经认知衰老

• 批准号: 10351738
• 负责人: Edward W Large
• 金额: $ 19.74万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10351738
• 关键词: Acoustic Stimulation; Acoustics; Address; Affect; Aging; Alzheimer' s disease model; Alzheimer’s disease biomarker; Amyloid beta-Protein; Animal Model; Attention; Auditory; Behavior; Behavioral; Biological Models; Brain; Cognition; Cognitive; Cognitive aging; Collaborations; Comprehension; Computer software; Coupled; Coupling; Dementia; Development; Devices; Double-Blind Method; Elderly; Electroencephalography; Feasibility Studies; Frequencies; Gene Expression; Geriatrics; Health; Human; Impaired cognition; Individual; Knowledge; Light; Link; Longevity; Memory; Methods; Microglia; Modeling; Motor; Music; Neural Network Simulation; Neurocognitive; Neurologic; Neurology; Neurons; Neurosciences; Nonlinear Dynamics; Pattern; Perception; Performance; Periodicity; Photic Stimulation; Placebo Control; Population; Process; Randomized; Randomized Controlled Trials; Research Personnel; Role; Scalp structure; Science; Sensory; Short-Term Memory; Signal Transduction; Synapses; System; Testing; Time; Transcranial magnetic stimulation; Visual; Work; cell type; experience; improved; indexing; innovation; mouse model; multimodality; neurophysiology; neuroregulation; noninvasive brain stimulation; optogenetics; relating to nervous system; signal processing; tool; young adult

Abstract Music that we encounter every day contains amplitude and frequency modulations, rapid changes in acoustic signals that convey meaningful information to the listener. The human brain’s ability to receive and interpret meaning from these signals is implemented by networks of neural oscillations: firing patterns of groups of neurons that track the music with rhythmic activity. Neural oscillations in different frequency bands subserve attention and memory, as well as perception and comprehension; they develop over the lifespan and are reduced in aging, especially in dementia. Being able to understand and causally control neural oscillations will have crucial implications for healthy neurocognitive aging. Since music naturally stimulates the brain with its rhythmic content over time, we hypothesize that music can be used as a sustainable, naturalistic form of brain stimulation to induce oscillatory in neuronal populations. Furthermore, we hypothesize that by inserting gamma-band energy as sensory stimulation during music listening, we can increase gamma-band activity in the brain in a way that is frequency-tuned to the brain’s intrinsic network dynamics, thus replacing the decreased neural oscillations that are reduced in aging, and improving memory and cognition in older adults. We hypothesize that gamma-band modulations inserted in lights, when coupled with music listening, can improve memory in older adults by frequency-tuning to intrinsic individual brain network dynamics. Here we propose the first randomized, double-blind, placebo-controlled feasibility study, to test the effects of music-coupled gamma-band stimulation on EEG and behavioral indices of working memory in older adults. Results will test the causal role of oscillatory mechanisms of the brain on cognition. If successful, this trial will lay the groundwork to the first musical, neurophysiologically targeted, brain-stimulation device for reversing cognitive decline in aging.

抽象的 我们每天遇到的音乐包含放大器和频率调制， 传达有意义信息的声学信号的快速变化向听众传达有意义的信息。 人脑从这些信号中接收和解释意义的能力是 由神经元网络实施：神经元组的触发模式 通过有节奏的活动跟踪音乐。不同频段的神经振荡 提供注意力和记忆，以及感知和理解；他们 在整个生命周期内发展，并在衰老中降低，尤其是在痴呆症中。有能力 了解和因果控制神经振荡将对 健康的神经认知衰老。由于音乐自然会用它的大脑刺激大脑 随着时间的流逝，我们假设音乐可以用作可持续性， 脑模拟的自然主义形式在神经元种群中诱导振荡。 此外，我们通过将伽马波段的能量插入感觉来假设 在音乐聆听过程中刺激，我们可以增加大脑中的伽马频段活动 一种频率调整到大脑内在网络动态的方式，从而替换 衰老减少的神经振荡减少，并改善记忆力和 老年人的认知。我们假设插入的伽玛波段调制 当灯与音乐聆听结合时，可以通过 频率调节到固有的单个大脑网络动力学。在这里我们提出 首次随机，双盲，安慰剂控制的可行性研究，以测试 音乐耦合的γ波段刺激在脑电图和工作行为指数上 老年人的记忆。结果将测试振荡机制的因果关系 认知的大脑。如果成功的话，该试验将为第一首音乐奠定基础 神经生理学靶向的脑刺激装置，用于逆转认知能力下降 老化。