Role and Mechanism of Hearing Impairment in Cognitive Decline and Dementia

听力障碍在认知衰退和痴呆中的作用和机制

• 批准号: 10600208
• 负责人: JENNIFER Anne DEAL
• 金额: $ 12.63万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10600208
• 关键词: Acoustic Stimulation; Address; Affect; Age; Aging; Air; Alzheimer' s Disease; Alzheimer' s disease brain; Amyloid beta-Protein; Ankle; Applications Grants; Appointment; Area; Atherosclerosis Risk in Communities; Attenuated; Audiology; Auditory; Award; Baltimore; Biological Markers; Blood Vessels; Brain; Brain imaging; Brain region; Cerebrovascular Disorders; Cerebrum; Clinic; Clinical; Clinical Research; Cognitive; Cognitive aging; Data; Data Analyses; Dementia; Development; Diabetes Mellitus; Diagnosis; Disease; Disease Marker; Educational workshop; Elderly; Epidemiologist; Epidemiology; Five-Year Plans; Functional disorder; Funding; Fundus photography; Future; Goals; Head and Neck Surgery; Health; Healthcare; Hearing; Hearing Aids; Hearing Tests; Hypertension; Impaired cognition; Individual; Interdisciplinary Study; Intervention; K-Series Research Career Programs; Knowledge; Lacunar Infarctions; Lead; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mentors; Methods; Obesity; Observational Study; Otolaryngology; Participant; Pathology; Pathway interactions; Peripheral; Population Study; Positioning Attribute; Poverty; Process; Publications; Publishing; Pure-Tone Audiometry; Reporting; Research; Research Personnel; Resources; Retina; Risk Factors; Role; Scientist; Signal Transduction; Smoking; Techniques; Testing; Time; Training; Training Programs; United States National Academy of Sciences; United States National Institutes of Health; Universities; White Matter Hyperintensity; abeta deposition; adjudicate; adverse outcome; aging brain; auditory processing; aural rehabilitation; base; brain volume; career; cerebrovascular; clinical translation; cognitive function; cognitive neuroscience; cohort; disability; empowered; epidemiology study; healthy aging; hearing impairment; imaging facilities; imaging science; improved; indexing; informal learning; insight; medical schools; middle age; modifiable risk; mortality; neurocognitive test; neuroimaging; neuron loss; prevent; prospective; skills; tau Proteins; vascular factor; vascular risk factor; β-amyloid burden

ABSTRACT Jennifer A. Deal is an epidemiologist and gerontologist, with a position as Assistant Scientist in the Department of Epidemiology, Johns Hopkins Bloomberg School of Medicine and a secondary appointment in the Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine. She seeks a mentored career development award to fill knowledge gaps in her current training so that her research can successfully bridge the diverse fields of cognitive aging, audiology, otolaryngology, epidemiology and cognitive neuroscience in order to improve the health of older adults. The training proposal describes a comprehensive five-year plan of formal and informal instruction in the clinical aspects and pathophysiology of hearing impairment, as well as the acquisition, analysis and processing of neuroimaging data in large population-based studies. The training program consists of didactic coursework and seminars, clinic observations, and mentored research by an established and diverse team of experts. Short-term career goals include completion and dissemination of high-quality mentored research through publications and presentations and application for independent R01 funding beginning in the fourth year of the award period. Long-term career goals are to be an independent investigator in the area of aging and cognitive decline and dementia, with expertise in hearing impairment. The specific aims of the proposed research are to quantify the independent association of HI incident dementia and with domain-specific cognitive decline in three well-characterized prospective observational studies, to investigate the relationship of HI with changes in brain volume over time (both in regions related to Alzheimer’s disease and to auditory processing), and to quantify the role of vascular factors in the development of HI. Completion of the proposed aims will elucidate the role and mechanism of hearing impairment in dementia and domain-specific cognitive decline, providing possible targets for future clinical research with the potential to inform efforts to prevent these adverse outcomes in older adults.

抽象的 Jennifer A. Deal是一名流行病学家和老年医生，在该部门担任助理科学家 流行病学，约翰·霍普金斯彭博医学院和次要任命 Johns Hopkins医学院耳鼻喉科头和颈部外科手术系。她寻求一个 指导的职业发展奖，以填补当前培训中的知识空白，以便她的研究可以 成功地弥合了认知衰老，听力学，耳鼻喉科，流行病学和认知的潜水领域 神经科学以改善老年人的健康。 该培训建议描述了临床中正式和非正式教学的五年全面计划 听力障碍的方面和病理生理学以及对的获取，分析和处理 在大型基于人群的研究中神经影像学数据。培训计划包括教学课程 以及一个成熟且潜水的专家团队的SEMIAR，诊所观察和指导研究。 短期职业目标包括完成和通过 出版物和演示文稿以及独立R01资金的申请。 奖励期。长期职业目标是成为衰老和认知领域的独立研究者 衰落和痴呆症，具有听力障碍的专业知识。 拟议研究的具体目的是量化HI入射痴呆的独立关联 并在三个特征良好的前瞻性观察性研究中，域特异性认知能力下降， 调查HI与大脑体积随时间变化的关系（在与阿尔茨海默氏症相关的地区 疾病和听觉处理），并量化血管因素在HI发展中的作用。 拟议目标的完成将阐明听力障碍在痴呆症和 领域特异性的认知能力下降，为未来的临床研究提供了可能的靶标 为防止老年人的这些不良后果而努力。

项目成果

Associations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States.

• DOI: 10.1016/j.jad.2022.07.067
• 发表时间: 2022-11-15
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Armstrong, Nicole M.;Teixeira, Camila Vieira Ligo;Gendron, Colby;Brenowitz, Willa D.;Lin, Frank R.;Swenor, Bonnelin;Powell, Danielle S.;Deal, Jennifer A.;Simonsick, Eleanor M.;Jones, Richard N.
• 通讯作者: Jones, Richard N.

Associations of dual sensory impairment with incident mobility and ADL difficulty.

• DOI: 10.1111/jgs.17764
• 发表时间: 2022-07
• 期刊: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
• 影响因子: 6.3
• 作者: Armstrong, Nicole M.;Teixeira, Camila Vieira Ligo;Gendron, Colby;Brenowitz, Willa D.;Lin, Frank R.;Swenor, Bonnelin;Deal, Jennifer A.;Simonsick, Eleanor M.;Jones, Richard N.
• 通讯作者: Jones, Richard N.

Prevalence of Asymmetric Hearing Among Adults in the United States.

• DOI: 10.1097/mao.0000000000002931
• 发表时间: 2021-02-01
• 期刊: OTOLOGY & NEUROTOLOGY
• 影响因子: 2.1
• 作者: Suen, Jonathan J.;Betz, Joshua;Reed, Nicholas S.;Deal, Jennifer A.;Lin, Frank R.;Goman, Adele M.
• 通讯作者: Goman, Adele M.

Response to Letter From Fuller-Thomson "Might Lifetime Exposure to Lead Confound the Association between Hearing Impairment and Incident Dementia?"

对 Fuller-Thomson 来信的回应“终生接触铅是否会混淆听力障碍与意外痴呆之间的关联？”

• DOI: 10.1093/gerona/gly007
• 发表时间: 2018
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Deal,JenniferA;Lin,FrankR
• 通讯作者: Lin,FrankR

Factors Associated with Poor Olfaction and Olfactory Decline in Older Adults in the ARIC Neurocognitive Study.

• DOI: 10.3390/nu15163641
• 发表时间: 2023-08-19
• 期刊: NUTRIENTS
• 影响因子: 5.9
• 作者: Shrestha, Srishti;Zhu, Xiaoqian;Kamath, Vidyulata;Sullivan, Kevin J.;Deal, Jennifer A.;Sharrett, A. Richey;Schneider, Andrea L. C.;Palta, Priya;Gottesman, Rebecca F.;Windham, B. Gwen;Mosley, Thomas H.;Griswold, Michael E.;Chen, Honglei;Dakanalis, Antonios
• 通讯作者: Dakanalis, Antonios