Psychological and inflammatory biobehavioral mechanisms underlying the association between bereavement and cardiovascular disease

丧亲之痛与心血管疾病之间关联的心理和炎症生物行为机制

• 批准号: 9921206
• 负责人: Anoushka D. Shahane
• 金额: $ 4.55万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-17 至 2022-05-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9921206
• 关键词: 18 year old; Accounting; Address; Adult; Age; Back; Bereavement; Biological; Biological Assay; Biological Markers; Blood; C-reactive protein; Cardiovascular Diseases; Cessation of life; Climacteric; Clinical; Dependence; Development; Emotional; Emotions; Equation; Exhibits; Funding; Future; Gender; Goals; Grief reaction; Guilt; Health; Heart; Heart Diseases; Hematological Disease; Immunologic Factors; Individual; Inflammation; Inflammatory; Inflammatory Response; Interleukin-10; Interleukin-6; Intervention; Interview; Knowledge; Language; Lesion; Letters; Light; Linguistics; Link; Longevity; Lung; Mediating; Mental Depression; Mental Health; Methods; Mission; Modeling; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Negative Valence; Oral; Outcome; Participant; Persons; Phase; Physical activity; Physiological; Population; Procedures; Psychological Factors; Psychoneuroimmunology; Psychotherapy; Public Health; Questionnaires; Reaction; Research Design; Risk; Role; Serum; Sleeplessness; Spouses; Standardization; Stimulus; Stress; Structure; TNF gene; Training; Transcript; Vulnerable Populations; Work; anakinra; biobehavior; blood treatment; cardiovascular disorder risk; cardiovascular risk factor; clinically relevant; clinically significant; coping; cytokine; depressive symptoms; design; disorder prevention; effective therapy; emotion regulation; emotional reaction; experience; immune function; improved; indexing; lexical; mortality; mortality risk; natural language; novel; perceived stress; physical conditioning; psychologic; resilience; response; skills; sleep quality; stressor

Project Summary The loss of a spouse is one of most stressful experiences one can encounter. In the face of such loss, people are physiologically and emotionally dysregulated. As a result, bereaved individuals are at increased risk of cardiovascular disease (CVD), morbidity, and mortality. CVD accounts for an astounding 20-53% of deaths following loss of a spouse. Highly stressed individuals, such as bereaved spouses, exhibit heightened inflammatory responses in comparison to those who are less stressed. Importantly, inflammation is a predictor of all stages of CVD from initial lesion to end-stage thrombotic complications. Therefore, as bereaved individuals are highly stressed and at increased risk of CVD, inflammation may be a key mechanism underlying this CVD risk. Further, bereavement-related stress is often manifested in emotional and physical reactions such as despair, symptoms of depression, excessive grief rumination, insomnia, and decreased physical activity. In bereavement, the ability to successfully regulate emotion is a vital skill for healthy coping, predictive of health outcomes, and may represent a key psychological mechanism accounting for varying degrees of resilience. Psychological distancing is one promising adaptive emotion regulation strategy in which an individual appraises a negative situation by taking a step back, distancing oneself, and coolly, objectively evaluates what is happening. The objective of the present work is to investigate if psychological distancing, implemented implicitly via natural language use (i.e., linguistic distancing (LD)), is related to proinflammatory cytokine biomarkers of CVD risk and bereavement-related health indicators. 160 participants who experienced the loss of their spouse within the last two months will complete questionnaires that index bereavement-related health indices (i.e., risk for mortality, general health, symptoms of depression, perceived stress, grief rumination, sleep quality, and physical activity), and undergo a blood draw to assess proinflammatory cytokine biomarkers of CVD risk. Participants will be asked to discuss their relationship with the deceased spouse for six minutes while being recorded. To assess LD, lexical assays of each participant's oral transcripts will index the extent of his or her spontaneous psychological distancing using a well-established, standardized LD metric. Greater LD scores indicate greater psychological distancing and have been associated with more adaptive emotion regulation and health indices. Primary aims include assessing (1) if LD is negatively associated with CVD- related proinflammatory cytokine responses, (2) if LD is negatively related to deleterious bereavement-related health indicators, and (3) as an exploratory aim, examining and characterizing functional interrelationships among LD, proinflammatory cytokine responses, and bereavement-related health indices. This work may explain novel dependencies among language, emotion, and CVD risk, identify resilience factors, and probe the translational value of LD in this vulnerable population to inform the future design of scalable, effective treatments to reduce risk of CVD, morbidity, and mortality.

项目摘要 失去配偶是人们可能遇到的最紧张的经历之一。面对这种损失，人们是 生理和情感失调。结果，丧亲的个体的风险增加 心血管疾病（CVD），发病率和死亡率。 CVD占死亡人数的20-53％ 失去配偶后。高应压力的人，例如丧亲的配偶，表现出来 与压力较小的人相比，炎症反应。重要的是，炎症是预测因子 从初始病变到终阶段血栓形成并发症的CVD的所有阶段。因此，丧亲 个体高度压力，在CVD的风险增加时，炎症可能是基础的关键机制 这个CVD风险。此外，与丧亲相关的压力通常在情感和身体反应中表现出来 作为绝望，抑郁症的症状，过度的悲伤反省，失眠和体育锻炼减少。在 丧亲，成功调节情绪的能力是健康应对的重要技能，可预测健康 结果，并且可能代表着一种关键的心理机制，该机制占不同程度的弹性。 心理距离是一种有前途的自适应情感调节策略 通过退后一步，疏远自我并冷静，客观地评估什么是什么，从而评估了负面情况 发生。本工作的目的是调查心理距离是否实施 隐式通过自然语言使用（即语言距离（LD））与促炎性细胞因子有关 CVD风险和丧亲有关的健康指标的生物标志物。经历了损失的160名参与者 在过去两个月内，他们的配偶将完成与丧亲有关的健康的调查表 指数（即死亡率，一般健康，抑郁症状，感知压力，悲伤反省的风险， 睡眠质量和体育锻炼），并接受抽血以评估促炎性细胞因子生物标志物 CVD风险。将要求参与者与死者配偶讨论他们的关系六分钟 同时被录制。为了评估LD，每个参与者的口头成绩单的词汇测定将索引 他或她的心理距离使用良好，标准化的LD度量。更大的LD 分数表明心理距离更大，并且与更适应性的情感相关 法规和健康指数。主要目的包括评估（1）如果LD与CVD负相关 相关促炎细胞因子反应，（2）如果LD与有害丧亲有关 健康指标，（3）作为探索目的，研究和表征功能相互关系 在LD中，促炎性细胞因子反应和丧亲相关的健康指数。这项工作可能 解释语言，情感和CVD风险之间的新颖依赖性，确定弹性因素，并探究 LD在这个脆弱人群中的翻译价值，以告知未来的可扩展性，有效的设计 降低CVD，发病率和死亡率的治疗方法。