Osteoporotic Fractures in Men (MrOS) - Minneapolis

男性骨质疏松性骨折 (MrOS) - 明尼阿波利斯

• 批准号: 9920360
• 负责人: KRISTINE ENSRUD
• 金额: $ 16.81万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920360
• 关键词: Accelerometer; Age; Age Factors; Aging; Area; Biological Factors; Bone Density; Bone structure; Cessation of life; Characteristics; Clinical; Data; Deterioration; Development; Disease; Elderly; Energy Metabolism; Finite Element Analysis; Fostering; Fracture; Gait speed; Goals; Gonadal Steroid Hormones; Hand Strength; Health; Health care facility; Healthcare; Hospitalization; Impaired cognition; Inflammation; Inpatients; Lead; Leg; Long-Term Care; Maintenance; Measurement; Measures; Medicare claim; Mission; Morbidity - disease rate; Muscle; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nursing Homes; Older Population; Osteoporosis; Outcome; Participant; Peripheral; Phase; Phenotype; Physical Performance; Physical activity; Porosity; Predictive Factor; Preventive measure; Process; Property; Prospective Studies; Questionnaires; Radial; Rehabilitation therapy; Renal function; Research; Resolution; Resources; Risk; Science; Scientific Inquiry; Scientist; Skilled Nursing Facilities; Testing; Thinness; Visit; Vitamin D; Woman; X-Ray Computed Tomography; active lifestyle; adverse outcome; age related; bone; bone strength; career; cohort; cortical bone; data warehouse; design; disability; falls; follow-up; fracture risk; health care service utilization; hospital readmission; image archival system; improved; investigator training; men; mortality; novel; older men; osteoporosis with pathological fracture; physical conditioning; prevent; repository; sarcopenia; sedentary lifestyle; skeletal; tibia; web site

Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.

与年龄相关的骨骼，肌肉和身体性能恶化，表现为骨质疏松症，肌肉减少症， 和残疾是老年人发病和死亡率的主要原因。要了解如何 肌肉骨骼表型和体育活动随着年龄的变化而变化，这些因素有助于这些 变化以及变化如何影响临床上重要的健康结果。 MROS是一项独特的前瞻性研究 在扩大我们对年龄相关变化的理解方面，有5994名年长的男人 在肌肉骨骼健康中。它于2000年启动，包括广泛的纵向，客观，最先进的 评估骨骼，肌肉，身体表现，体育锻炼和健康结果，以及 生物播种和成像档案。我们建议扩展这些资源，以允许全面和 对肌肉骨骼衰老和身体下降的过程和后果的综合理解 在15年内学习的老年男性的活动。该项目的总体长期目标是身份男人 有可能从预防措施和康复中受益的不良健康结果的风险，发现新的 治疗和防止肌肉骨骼健康和活动下降的目标，并改善我们的 了解最佳衰老（男性维持其肌肉骨骼健康和活动水平 15年的平均整体随访）。具体而言，我们将利用我们的重复测量来定义年龄 肌肉骨骼健康，身体表现和体育活动的表型中的相关轨迹 为了确定预测和促进这些轨迹的因素。我们将测试假设 肌肉骨骼健康中有利的轨迹与降低的跌落，骨折，较低的风险有关 残疾和死亡率以及与年龄相关的骨骼，肌肉和身体性能的恶化 同时；结合变质会放大功能不良和健康结果的风险。第二，我们 将使用我们重复的最新技术来表征老年男性活动水平的变化和轨迹 问卷和客观评估加速度计的能量消耗。第三，我们将利用 MRO与Medicare索赔数据的联系以确定肌肉骨骼中轨迹的关联 与住院和疗养院相关的医疗保健利用的表型和活动。第四，我们将检查 皮质骨的新型特征，可能通过使用高分辨率引起与年龄相关的骨骼脆弱性 外围定量计算机断层扫描以测量皮质孔隙度。我们将联系 肌肉骨骼的健康和活动对这些皮质骨的措施，并测试皮质是否增加 孔隙率与裂缝有关。最后，我们将继续利用MRO作为新科学的平台，并 调查人员的培训。我们的申请与NIA和NIAM的使命一致 与衰老过程以及与肌肉骨骼衰老相关的疾病和疾病有关的研究，以及 促进该科学领域的新研究科学家的发展。