Osteoporotic Fractures in Men (MrOS) - Minneapolis

男性骨质疏松性骨折 (MrOS) - 明尼阿波利斯

• 批准号: 8436871
• 负责人: KRISTINE ENSRUD
• 金额: $ 103.59万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8436871
• 关键词: Age; Age Factors; Aging; Aging-Related Process; Area; Behavior; Biological Factors; Bone Density; Cessation of life; Characteristics; Data; Databases; Deterioration; Development; Discipline of Nursing; Disease; Elderly; Energy Metabolism; Finite Element Analysis; Fostering; Fracture; Gait; Goals; Gonadal Steroid Hormones; Health; Healthcare; Home environment; Hospitalization; Impaired cognition; Inflammation; Inpatients; Lead; Leg; Life; Long-Term Care; Maintenance; Measurement; Measures; Medicare claim; Mission; Morbidity - disease rate; Muscle; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nursing Homes; Older Population; Osteoporosis; Outcome; Participant; Performance; Peripheral; Phase; Phenotype; Physical activity; Porosity; Preventive; Process; Property; Prospective Studies; Questionnaires; Radial; Rehabilitation therapy; Renal function; Research; Resolution; Resources; Risk; Science; Scientist; Skilled Nursing Facilities; Speed; Structure; Testing; Visit; Vitamin D; Woman; X-Ray Computed Tomography; adverse outcome; age related; bone; bone strength; career; cohort; design; disability; falls; follow-up; grasp; health care service utilization; image archival system; improved; investigator training; men; mortality; novel; older men; osteoporosis with pathological fracture; physical conditioning; prevent; public health relevance; repository; sarcopenia; sedentary; skeletal; tibia; web site

DESCRIPTION (provided by applicant): Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.

描述（由申请人提供）：与年龄相关的骨骼，肌肉和身体性能的恶化，表现为骨质疏松症，肌肉减少症和残疾，是老年人发病和死亡率的主要原因。优先了解肌肉骨骼表型和体育活动如何随着年龄的增长而变化，导致这些变化的因素以及变化如何影响临床上重要的健康结果。 MROS是一项对5994名老年男性的独特前瞻性研究，在扩展我们对肌肉骨骼健康与年龄相关的变化方面一直非常有生产力。它于2000年启动，包括对骨，肌肉，身体性能，身体活动和健康结果的广泛纵向，客观，最先进的评估，以及生物镜和成像档案。我们建议扩展这些资源，以允许对肌肉骨骼衰老的过程和后果进行全面和综合的理解，并在15年期间研究的老年男性体育锻炼的下降。该项目的总体长期目标是使患有不良健康成果的身份男性可能受益于预防措施和康复，发现治疗和预防肌肉骨骼健康和活动中下降的新目标，并提高我们对最佳衰老的理解（男性（男性）在平均15年的总体随访中，他们保持肌肉骨骼健康和活动水平）。具体而言，我们将利用重复的测量来定义肌肉骨骼健康，身体性能和体育活动表型中与年龄相关的轨迹，以确定预测和促进这些轨迹的因素。我们将测试假设，即肌肉骨骼健康中有利的轨迹与较低的事件风险下降，骨折，残疾和死亡率有关，并且骨骼，肌肉和身体性能的年龄相关的恶化可能会同时发生。结合变质会放大功能不良和健康结果的风险。其次，我们将使用反复的最新问卷调查表征老年男性活动水平的变化和轨迹，并客观地评估加速度计的能量消耗。第三，我们将利用MRO与Medicare索赔数据的联系，以确定肌肉骨骼表型中的轨迹和活动与住院和疗养院相关的医疗保健利用的关联。第四，我们将检查皮质骨的新型特征，这些特征可能通过使用高分辨率外围定量计算机断层扫描来测量皮质孔隙率，从而导致与年龄相关的骨骼脆弱性。我们将将肌肉骨骼健康和活性的轨迹与皮质骨的这些措施联系起来，并测试增加皮质孔隙率是否与裂缝有关。最后，我们将继续利用MRO作为新科学和调查人员培训的平台。我们的应用与NIA和NIAM的使命是一致的，该使命是进行与衰老过程以及与肌肉骨骼衰老相关的疾病和条件有关的研究，并促进该科学领域的新研究科学家的发展。