Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) Consortium

青少年大脑认知发展 (ABCD) 成熟研究 (PRISM) 联盟的前瞻性研究

基本信息

批准号：
9925462
负责人：
LINDA CHANG
金额：
$ 4.78万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2020-04-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9925462
关键词：
Academic achievement Adolescence Adolescent Affect Age Alcohol or Other Drugs use Alcohols Area Attention deficit hyperactivity disorder Basal Ganglia Behavioral Brain Cannabis Child Childhood Choline Clinical Clinical assessments Cognition Collaborations Comorbidity Complement Complex Conduct Disorder Core-Binding Factor Corpus striatum structure Data Analyses Deltastab Development Diffusion Disease Drug usage Emotions Enrollment Environment Environmental Risk Factor Epigenetic Process Evaluation Female Functional Magnetic Resonance Imaging Future Gender Genetic Genetic Predisposition to Disease Glutamates Goals Grouping Hawaii Image Individual Informatics Iron Leadership Link Longitudinal Studies Longitudinal cohort Longitudinal cohort study Longitudinal prospective study Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Maps Marijuana Measures Mediating Memory Mental Depression Mental Health Mental disorders Metabolic Methodology Monitor Motivation N-acetylaspartate Native Hawaiian Neurocognitive Neurophysiology - biologic function Neurotransmitters Nicotine Outcome Outcome Measure Pacific Island Americans Pattern Perfusion Pharmaceutical Preparations Population Heterogeneity Populations at Risk Predisposition Protocols documentation Psychopathology Psychotic Disorders Puberty Request for Applications Research Research Project Grants Resources Rewards Risk Risk Factors Sampling Site Spin Labels Structure Substance Use Disorder System Thalamic structure Tobacco U-Series Cooperative Agreements Universities Utah Youth adolescent substance use base behavioral health brain remodeling cognitive development cognitive performance connectome critical period density design early adolescence early onset substance use effective intervention emotion regulation environmental stressor executive function experience frontal lobe gamma-Aminobutyric Acid gray matter high risk indexing male marijuana use metabolic imaging multimodality myelination neurochemistry neuroimaging neurophysiology physical conditioning prospective protective factors psychosocial adjustment psychosocial development public health relevance racial diversity recruit reduced substance use research study sex social social cognition volunteer white matter

项目摘要

DESCRIPTION (provided by applicant): This cooperative agreement (U01) application responds to NIH RFA-DA-15-015, Adolescent Brain Cognitive Development (ABCD) study. The University of Hawaii (UH) is #2 of 9 Research Sites of the Prospective Research in Studies of Maturation (PRISM) Consortium. The Consortium's objective is to establish a national, multisite, longitudinal cohort to prospectively examine the neurodevelopmental and behavioral effects of substance use (SU) from early adolescence through the period of risk for SU and SU disorders. This 10-year longitudinal study of 11,000 children will measure brain development, SU, cognition, emotion, executive function, mental health, physical health, environment, and collect biospecimens for future genetic and epigenetic studies. The Consortium has an optimized research protocol and 4 specific aims: 1) Using advanced multi-modal neuroimaging to evaluate premorbid factors and the impact associated with diverse patterns of SU on structure and function of the developing brain. 2) Disentangle the predictors and consequences of diverse patterns of SU on physical health, psychosocial and cognitive development, academic achievement, motivation and emotional regulation. 3) Examine how the quantity and combination of substances used affect the expression of psychopathology and, conversely, how the emergence of psychopathology influences SU. 4) Assess how each substance used contributes to the use of other substances (gateway interactions). To further evaluate neurochemical and neurophysiological changes in these youth, we will additionally perform 1H MR spectroscopy (MRS), perfusion MRI (using arterial spin labeling or ASL), and quantitative susceptibility mapping (QSM), in approximately half of our volunteers, in collaboration with PRISM sites at Penn, UCLA, Utah, Hawaii, JHU, and Baylor. We are proposing a multi-PI leadership approach for our site. The PIs have complementary and inter- disciplinary expertise that encompasses all areas required to manage this comprehensive project. We have expertise in SUD research, clinical assessments, subject sampling and recruitment, and MR methodology. Additional unique qualifications of our site are: 1) we have access to a racially diverse population (including Native Hawaiians and Pacific Islanders) that is disproportionately affected by SUD, 2) we have a strong track record of MR research in SUD and at risk populations, such as adolescents, and 3) we have participated in and led several multi-center research studies that involve complex multi-modal MR outcome measures and subject assessments. Therefore, we have all the necessary resources, experience and expertise to conduct the proposed research, and our effort will complement that of other outstanding research sites to collectively achieve the overall goals of the PRISM Consortium.

描述（由申请人提供）：此合作协议 (U01) 申请响应 NIH RFA-DA-15-015，青少年大脑认知发展 (ABCD) 研究，夏威夷大学 (UH) 在 9 个研究中心中排名第 2。成熟研究前瞻性研究 (PRISM) 联盟的目标是建立一个全国性、多地点、纵向队列来前瞻性地研究神经发育和行为。这项针对 11,000 名儿童的为期 10 年的纵向研究将测量大脑发育、SU、认知、情绪、执行功能、心理健康、身体健康、从青春期早期到 SU 和 SU 疾病风险期的影响。该联盟有一个优化的研究方案和 4 个具体目标：1) 使用先进的多模式神经影像学来评估病前因素以及与不同模式相关的影响。 SU 对发育中大脑的结构和功能的影响 2) 理清不同 SU 模式对身体健康、心理社会和认知发展、学业成绩、动机和情绪调节的预测因素和后果 3) 检查所使用物质的数量和组合。影响精神病理学的表达，以及反过来，精神病理学的出现如何影响 SU。 4) 评估所使用的每种物质如何促进其他物质的使用（网关相互作用），以进一步评估这些青少年的神经化学和神经生理学变化。我们还将与宾夕法尼亚大学、加州大学洛杉矶分校、犹他州、夏威夷州的 PRISM 中心合作，对大约一半的志愿者进行 1H 磁共振波谱 (MRS)、灌注 MRI（使用动脉自旋标记或 ASL）和定量磁化率绘图 (QSM)我们为我们的网站提出了一种多 PI 领导方法，这些 PI 拥有涵盖管理这个综合项目所需的所有领域的专业知识。我们网站在 SUD 研究、临床评估、受试者抽样和招募以及 MR 方法方面的专业知识包括：1) 我们能够接触到受 SUD 影响尤为严重的不同种族人群（包括夏威夷原住民和太平洋岛民）， 2) 我们在 SUD 和青少年等高危人群的 MR 研究方面拥有良好的记录，3) 我们参与并领导了多项涉及复杂的多模式 MR 结果测量和受试者评估的多中心研究。因此，我们拥有进行拟议研究所需的所有资源、经验和专业知识，我们的努力将补充其他优秀研究机构的努力，共同实现 PRISM 联盟的总体目标。